Children's Panadol for adults. Panadol adult. Form, composition, packaging

Analgesic-antipyretic

Active substance

Release form, composition and packaging

◊ Oral suspension pink, viscous, with crystals and strawberry scent.

Excipients: malic acid, xanthan gum, maltitol, sorbitol, citric acid, sodium nipasept, strawberry flavor, azorubine, water.

100 ml - dark glass bottles (1) complete with a measuring syringe - cardboard boxes.
300 ml - dark glass bottles (1) complete with a measuring syringe - cardboard boxes.

pharmachologic effect

Analgesic-antipyretic. Has an analgesic and antipyretic effect. Blocks cyclooxygenase in the central nervous system, affecting pain and thermoregulation centers.

The anti-inflammatory effect is practically absent.

It does not affect the state of the gastrointestinal mucosa and water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics

Suction and distribution

Absorption is high. Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. Cmax is reached in 30-60 minutes.

Plasma protein binding is about 15%. The distribution of paracetamol in body fluids is relatively even.

Metabolism

Metabolized primarily in the liver with the formation of several metabolites. In newborns in the first two days of life and in children 3-10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children 12 years of age and older, it is conjugated glucuronide.

Part of the drug (approximately 17%) undergoes hydroxylation to form active metabolites that are conjugated with glutathione. With a lack of glutathione, these metabolites of paracetamol can block the enzyme systems of hepatocytes and cause their necrosis.

Removal

T1/2 when taking a therapeutic dose ranges from 2-3 hours. When taking therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is released after conjugation in the liver. No more than 3% of the received dose of paracetamol is excreted unchanged.

Indications

Used in children aged 3 months to 12 years:

• to reduce elevated body temperature against the background of colds, flu and childhood infectious diseases (including chicken pox, mumps, measles, rubella, scarlet fever);
• for toothache (including teething), headaches, ear pain with otitis media and with.

In children 2-3 months of age, a single dose is possible to reduce body temperature after vaccination.

Contraindications

• severe liver or kidney dysfunction;
• neonatal period;
• hypersensitivity to paracetamol or any other component of the drug.

WITH caution The drug should be used for liver dysfunction (including Gilbert's syndrome), kidney dysfunction, genetic absence of the enzyme glucose-6-phosphate dehydrogenase, severe blood diseases (severe anemia, leukopenia, thrombocytopenia).

The drug should not be taken simultaneously with other paracetamol-containing drugs.

Dosage

The drug is taken orally. The contents of the bottle should be shaken well before use. The measuring syringe placed inside the package allows you to dose the drug correctly and rationally.

The dose of the drug depends on the age and body weight of the child.

Children over 3 months the drug is prescribed at 15 mg/kg body weight 3-4 times/day, the maximum daily dose is no more than 60 mg/kg body weight. If necessary, you can take the drug every 4-6 hours in a single dose (15 mg/kg), but no more than 4 times within 24 hours.

Duration of use without consulting a doctor: to reduce temperature - no more than 3 days, to reduce pain - no more than 5 days.

In the future, as well as in the absence of a therapeutic effect, you should consult a doctor.

Side effects

From the digestive system: sometimes - nausea, vomiting, pain in the stomach.

Allergic reactions: sometimes - itching, urticaria, Quincke's edema.

From the hematopoietic system: rarely - anemia, thrombocytopenia, leukopenia.

Overdose

Symptoms acute paracetamol poisoning: nausea, vomiting, stomach pain, sweating, pale skin. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of liver enzymes). In severe cases, liver failure, encephalopathy and coma develop.

Treatment: Stop taking the drug and consult a doctor immediately. It is recommended to lavage the stomach and take enterosorbents (, polyphepan). The specific antidote for paracetamol poisoning is acetylcysteine.

In case of accidental overdose, seek immediate medical attention, even if the child feels well.

Drug interactions

When used together with barbiturates, diphenin, anticonvulsants, rifampicin, butadione, the risk of hepatotoxicity may increase.

When taken simultaneously with chloramphenicol (chloramphenicol), the toxicity of the latter may increase.

The anticoagulant effect of warfarin and other coumarin derivatives may be enhanced by long-term regular use of paracetamol, which increases the risk of bleeding.

special instructions

Children from 2 to 3 months and children born prematurely can be given Children's Panadol only as prescribed by a doctor.

When conducting tests to determine uric acid levels and serum levels, the physician must be aware of the patient's use of Children's Panadol.

Use in childhood

The drug is contraindicated during the neonatal period.

Storage conditions and periods

The drug should be stored in a place protected from light, out of reach of children, at a temperature not exceeding 30°C; do not freeze. Shelf life - 3 years.

When the temperature rises above 38 degrees, it is recommended to reduce it with medications using Panadol. This medicine reduces fever and relieves pain symptoms. The main component of the medicine: paracetamol, approved by WHO to relieve fever and eliminate pain.

Parents have no reason to worry when their children’s temperature rises sharply due to illness. High temperature causes the body to produce, which protects the body from viruses and bacteria, this is how the child’s body learns to cope with diseases.

Of course, there is no need to force the child to suffer if the high temperature causes inconvenience. Whether to give an antipyretic or not is determined by how the child feels. If he is weak, drowsy, capricious, does not feel well, feels pain, or signs of dehydration appear, it is better to bring down the temperature with Panadol or its analogues.

The main function of the product: lowering the temperature for colds and flu. With the help of Panadol, parents relieve fever when their children are sick with chickenpox, whooping cough, measles, rubella, scarlet fever, and other infections. Use it when , . Panadol is used for teething children.

The active component of the drug, paracetamol, is used to relieve fever after vaccinations. An important advantage of the medicine: the ability to use it for children from the third month of life. Paracetamol does not affect the water-salt metabolism of the child's body and the condition of the mucous membrane of the stomach and intestines.

Instructions for use and dosage

In pharmacy kiosks, Panadol is found in several forms. These include tablets, powder for preparing a solution, suppositories, syrup (suspension), and capsules. The form of medication taken by the patient depends entirely on the age, condition of the patient and sensitivity to the drug.

For young children, the medicine is available in several forms: suspension (syrup), rectal suppositories, tablets.

The suspension is used for oral use; it is bottled in 100 mg bottles. The syrup has a pleasant strawberry taste and aroma. The medicine box contains a measuring syringe and a dosage table, from which it is easy to understand how much the dosage will be depending on age and weight. After the child takes the antipyretic medicine (suspension), it acts within 20 minutes and remains effective for up to 3–4 hours.

The syrup is taken every 4–6 hours, depending on the severity of the disease. The syrup is given from the third month of life, which is convenient for the treatment of colds and infectious diseases in infants. The course without consulting a doctor is no more than 3 days. If the dose of medication is exceeded, it is recommended to consult a doctor.

Instructions for using Panadol are as follows:

• For children aged 2–3 months, syrup can be given only on an individual prescription from a pediatrician;
• For children 6–8 kg aged from three to six months, only 4 mg can be given once, the maximum daily dose for them will be 16 mg;
• For a baby aged from six months to a year weighing from 8 to 10 kilograms, no more than 5 mg of syrup can be given at a time, and the maximum dosage per day cannot be more than 20 mg;
• For children aged from one to two years, a single dose of medication is 7 mg, and the daily dose is 28 mg.

When treating fever and pain with suppositories, the recommended daily dose is no more than 4 pieces. Place Panadol suppositories 3-4 times every four to six hours. The effect of one candle reaches six hours. Suppositories are used when the child reaches six months of age. The therapeutic effect of the Panadol suppository begins 1–2 hours after rectal administration. The suppositories are administered rectally.

The medicine, produced in the form of tablets, is blisters designed for 6 and 12 tablets. The tablets themselves are white with embossing. Children are recommended to take tablets only from 6 years of age. The instructions say the maximum recommended dose per day is 4 tablets:

• A child from 6 to 9 years old is recommended to take half a tablet (250 mg) 3-4 times a day, with an interval of at least 4 hours. They are allowed to take a maximum of 2 tablets per day;
• A child from 9 to 12 years old is recommended to take one tablet 3-4 times a day; tablets should not be given more often than once every 4 hours.

Do not take the medicine for more than 5 days as a pain reliever and no more than 3 days as an antipyretic. Exceeding the dosage or increasing the course of treatment is permitted only by a doctor; you cannot increase the dosage of the medicine yourself.

When treated with metoclopramide, the rate of absorption of the active substance Panadol into the blood increases. Panadol enhances the effect of warfarin, possibly increasing the risk of bleeding. The use of barbiturates reduces the antipyretic effect of the active substance of the drug, possibly increasing the toxic effect of the liver. The antipyretic drug Panadol reduces the effect of diuretics.

Contraindications and side effects

• Panadol is not recommended for use with other drugs containing paracetamol to avoid overdose;
• The product should not be taken by children with kidney and liver diseases;
• If the patient is given a concurrent course of rifampicin or treatment with anticonvulsants, there is a risk of toxicological liver damage;
• The medicine is recommended to be used with caution in children under 3 months;
• Panadol should not be used for children with fructose intolerance;
• The medicine is not given to premature infants who are underweight;
• Sometimes the drug causes a laxative effect.

Among the adverse reactions to the drug, doctors record allergic reactions in the form of rashes on the skin. They stop when the drug is discontinued within 24–48 hours. Side effects become fully apparent when the drug is overdosed. On the first day, pale skin, abdominal pain, nausea and vomiting occur. On the first or second day after an overdose, toxic damage to the kidneys and liver occurs, up to the development of liver failure, the consequences of which can be coma or death. Cardiac arrhythmia and pancreatitis may occur.

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In case of an overdose of the drug, immediate medical attention is necessary, even if the symptoms have not yet manifested themselves.

At home, the stomach is washed and prescribed. After exceeding the dosage, N-acetylcysteine ​​or methionine is prescribed for 2 days. If necessary, the doctor prescribes an alpha-blocker as maintenance therapy. After an overdose, a period of increased sensitivity to iodine-containing drugs is possible.

Analogs

This medicine has many analogues that have antipyretic and analgesic effects. Analogue medications are developed on the basis of various substances (paracetamol, ibuprofen, etc.). For example, analogues of Panadol are drugs containing paracetamol:

Nurofen, the main substance of which is ibuprofen. Nurofen is available in the form of effervescent tablets, suppositories, and syrup. Nurofen is available in orange or strawberry flavors. The bottle of Nurofen syrup has protection against small patients so that the child does not open and drink the sweet syrup. It is also equipped with a plastic measuring syringe, which will help avoid overdose. The drug effectively copes with the reduction of fever during colds and infectious diseases, relieves pain of various origins.

Drug price

The price of Panadol depends on the trade markup of pharmacies, the region of the country in which the medicine was purchased and on the form of release. For example, the price of a medicine produced in the form of rectal suppositories varies from 66 rubles to 69 rubles. The syrup form of the medicine costs from 93 to 99 rubles, depending on the pharmacy chain, trade markup, and drug supplier. On average, the price of medicine in tablet form varies from 29 to 33 rubles. It is worth remembering that the delivery of medicine from an online pharmacy to the client is prohibited according to federal legislation on the circulation of medicines.

Thank you

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

What kind of drug is Panadol, and what is it for?

Panadol has two main effects - antipyretic and analgesic, which explains its widespread and almost universal use. Contrary to popular belief, this drug has virtually no anti-inflammatory effect. The list of indications is very wide, and it can be divided into two main groups.

The first group of pathologies are diseases with severe pain.

Pathologies with severe pain syndrome for which Panadol is used include:

• arthralgia ( joint pain);
• pain during menstruation.

The second group of indications are various colds accompanied by fever. In this case, Panadol is prescribed as a symptomatic treatment for influenza, pneumonia, bronchitis and fever of unknown origin. The antipyretic effect is also associated with blockade of the enzyme cyclooxygenase and, as a consequence, prostaglandins. Inhibition of prostaglandins in the hypothalamic thermoregulation center leads to temporary elimination of fever. In addition, panadol increases heat transfer, which also leads to a decrease in temperature.

Thus, both effects of Panadol are due to the blockade of prostaglandin synthesis. The difference is the location. Inhibition of prostaglandins in the thermoregulation center leads to a decrease in temperature, and a similar effect in the pain center is accompanied by an analgesic effect. Both centers are located in the hypothalamus.

Active ingredient: Panadol

When taken orally, paracetamol is well absorbed from the gastrointestinal tract. After absorption through the mucous membrane, it penetrates into the blood, where it binds to plasma proteins by 15 percent. Paracetamol is transported through the bloodstream to the liver, where most of it is subject to conjugation ( tying) with glucuronic and sulfuric acid. As a result of this reaction, non-toxic to the body and easily excreted metabolites are formed. Subsequently, these metabolites ( glucuronide and sulfates) are excreted by the kidneys within 20–24 hours. If creatinine clearance is less than 20 milliliters per minute ( what is observed in renal failure), the elimination of the drug slows down several times.

The maximum concentration of paracetamol in the blood after a single dose is reached within an hour. So, when taking one tablet orally ( 500 milligrams) within an hour the concentration of panadol is 6 micrograms per kilogram of weight. The drug is quickly eliminated by the kidneys, so after 5 - 6 hours the concentration of Panadol is halved. Distribution of the drug occurs mainly in body fluids, with the exception of cerebrospinal fluid. About one percent of the drug passes into breast milk, which should, of course, be taken into account by nursing women.

The metabolism of the drug depends on the general condition of the body, namely on the functionality of the kidneys and liver. Thus, with cirrhosis of the liver and other diseases of this organ, the metabolism of Panadol slows down. As a result, the drug circulates in the body longer, which increases the risk of toxic effects.

The half-life of Panadol ranges from 2 to 4 hours, and in case of renal failure it increases to 6 hours. During this time, the concentration of the drug in the blood is halved, and half of Panadol is excreted from the body.

What does Panadol help with?

The main indication for the use of Panadol is fever in children and adults. The mechanism of antipyretic action is to influence the thermoregulation center, which is located in the hypothalamus. The indication for the use of Panadol is fever of various etiologies, and even fever of unknown origin.
It is important to know that Panadol does not have an anti-inflammatory effect. Therefore, it makes no sense to prescribe it for colds without fever. It is also not recommended to take Panadol for rheumatic diseases and connective tissue diseases.

How does Panadol work?

The mechanism of fever is due to an increase in the level of prostaglandins in the thermoregulatory center. The front part of this part of the brain receives information from thermoreceptors, while the back part ( heat production center) sends impulses back to muscles, skin vessels and other organs. Due to this, overall metabolism increases and thermoregulation processes in the muscles are activated. The heat transfer center is located in the nuclei of the anterior hypothalamus. Impulses coming from these areas lead to a decrease in heat production due to the expansion of blood vessels and increased heat release. In addition to prostaglandins, both reactions also involve hormones such as adrenaline, thyroxine and others. The constancy of temperature is due to the mutual regulation of the processes of heat production and heat transfer.

The activation of certain heat exchange mechanisms occurs depending on specific conditions. For example, when the ambient temperature drops, a mechanism such as shivering is activated, which increases heat transfer. In other words, the thermoregulation center is constantly tuned to maintain a certain body temperature - comfort temperature. To maintain this comfort, it is necessary that the air temperature in the room be no more than 25 degrees, and at the body level there would be no pyrogenic ( antipyretic) processes. Any change in these conditions leads to irritation of the corresponding receptors in the hypothalamus and a change in temperature.

The analgesic mechanism of action of panadol is similar to the antipyretic effect. A key link is also the blockade of the synthesis of prostaglandins - pain mediators. The blockade is carried out at the level of the cyclooxygenase enzyme.

In the mechanism of pain, the main role is played by the increased sensitivity of nerve endings ( nociceptors) under the influence of substances, namely prostaglandins. In addition to prostaglandins, other mediators are involved in increasing sensitivity to pain - histamine, cytokines. As a rule, these are mediators from the inflammatory group that have many effects. Some increase vascular permeability and generate edema, others trigger allergic processes. In the occurrence of pain, the most significant are prostaglandins, namely prostaglandins of the E2 group, which most increase the sensitivity of receptors to pain.

Thus, a vicious circle is observed - tissue damage is accompanied by the release of chemicals that increase both the processes of inflammation and pain. In turn, pain symptoms affect the functioning of many systems. That is why many experts recommend eliminating pain, since it is an important component of the treatment of many diseases.

To enhance the analgesic effect of Panadol, caffeine or other components are often added to combination drugs. Caffeine improves absorption ( suction) panadol and thereby enhances the analgesic effect.

How long does it take to work ( brings down the temperature) panadol?

How long does Panadol last?

The speed of effect and action of Panadol is also influenced by the physiological characteristics of the body. First of all, it is age. Thus, in children, due to the larger volume of circulating fluid and intensive metabolism, the effect occurs much faster - within 20 minutes. However, at the same time, it does not last long - up to one hour. In people over 60–65 years of age, the volume of circulating fluid decreases several times, as a result of which the metabolism of the drug slows down. Therefore, the effect occurs not after half an hour, but after an hour and a half. Due to decreased kidney function ( which naturally occurs with age) the rate of elimination of panadol is reduced, which also increases its circulation time. The consequence of this is a long-term analgesic and antipyretic effect.

Can children have Panadol?

In this case, in children, especially small ones, the rectal route of administration is preferable. In this case, the age dosage remains the same. The difference between the rectal route of administration is the rapid development of the effect. This is explained by the abundant blood supply to the rectum, which facilitates the absorption of the drug and, as a result, its faster action.

Panadol during pregnancy

Panadol during breastfeeding

Instructions for use of Panadol

Release forms, doses and composition of Panadol

Panadol effervescent

Panadol tablets

Panadol syrup

Candles and suppositories

Children's Panadol suppositories are available in 125 and 250 milligrams. It is recommended to use 1 suppository 2 to 4 times a day every 6 hours. The duration of action of one candle is 6 hours.

Panadol extra

Indications for Panadol extra are:

• migraine;
• headache and toothache;
• lumbar pain;
• muscle pain ( myalgia);
• painful menstruation;
• flu;
• fever.

Use of Panadol

It is recommended to swallow the tablets of the drug whole, without chewing or crushing, with a sufficient amount of water. Effervescent version of Panadol ( for example, Panadol Soluble) should be dissolved in a glass of water before taking. The duration of treatment with Panadol, as well as its dose, are determined by the attending physician individually for each patient. However, on average the duration should not exceed 5 – 7 days. The daily dose for adults and adolescents over 12 years of age should not exceed 4 grams, and a single dose - 1 gram. As a rule, the doctor prescribes 500–1000 milligrams ( one - two tablets) 4 times a day. In this case, it is necessary to maintain an interval between taking the drug of at least 4 hours. For children aged 6 to 12 years, it is recommended to take 250–500 milligrams also 4 times a day with an interval of 4–6 hours.

Thus, the permissible daily dose for adults is 4000 milligrams ( 4 grams), and for children – 2000 milligrams. It is also important not to exceed the duration of taking the drug. If the expected effect does not occur within 3 days, then further use of the drug is not advisable.

The use of Panadol depends on the category of the patient ( child or adult), as well as from the readings. So, as a rule, Panadol is prescribed as an antipyretic.

Panadol for headaches and toothaches

Panadol suspension for teething

Contraindications to taking Panadol

In general, Panadol has a narrow range of contraindications, and it is limited to chronic decompensated pathologies of the liver and kidneys.
Specific contraindications include the absence of the enzyme glucose-6-phosphate dehydrogenase and blood diseases. Panadol should be used with caution during pregnancy and breastfeeding.

Contraindications to the use of Panadol are:

• hypersensitivity to paracetamol;
• cirrhosis, hepatitis and other liver dysfunctions;
• chronic or acute renal failure;
• genetic deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• blood pathologies;
• pregnancy;
• chronic alcoholism.

Liver dysfunction

Thus, the condition of the liver directly affects the activity of Panadol. If liver function is impaired, the process of formation of inactive metabolites slows down. This leads to prolonged circulation of the drug and prolongation of its action, and this, in turn, increases the risk of side effects.

Kidney failure

Genetic deficiency of the enzyme glucose-6-phosphate dehydrogenase

Blood pathologies

Pregnancy and breastfeeding

Chronic active alcoholism

Side effects of Panadol

Side effects of Panadol

System

List of side effects

Hepatobiliary system(liver and bile ducts) anti-inflammatory drugs ( NSAIDs). Liver damage and gastrointestinal symptoms are recorded in patients with pathologies of the corresponding systems. The cost of Panadol in various cities of Russia and reviews of the drug Panadol is not a rare drug in Russian pharmacies. It is in great demand especially in the autumn-winter period. Prices for the drug vary depending on the region. The cost of Panadol in Russian cities City Tablets, 500 milligrams, 12 pieces Soluble tablets, 500 milligrams, 12 pieces Syrup, 100 milliliters Rectal suppositories, 250 milligrams, 10 pieces Moscow Saint Petersburg Tver Krasnoyarsk Krasnodar Nizhny Novgorod In this article you can read the instructions for use of the drug Panadol. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Panadol in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Panadol in the presence of existing structural analogues. Use for the treatment of various pains and fever in adults, children, as well as during pregnancy and breastfeeding. Composition of the drug. Panadol- analgesic-antipyretic. Has an analgesic and antipyretic effect. Panadol Extra contains paracetamol or a combination of two active ingredients: paracetamol and caffeine. Paracetamol blocks COX in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa. Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance. Compound Paracetamol + excipients. Paracetamol + caffeine + excipients (Panadol Extra). Suppositories and syrup for children contain only paracetamol. Pharmacokinetics Absorption is high. Panadol is quickly and almost completely absorbed from the gastrointestinal tract. The distribution of paracetamol in body fluids is relatively even. Metabolized primarily in the liver with the formation of several metabolites. In newborns in the first two days of life and in children 3-10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children 12 years of age and older, it is conjugated glucuronide. When taking therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is released after conjugation in the liver. No more than 3% of the received dose of paracetamol is excreted unchanged. Indications headache; migraine; toothache; lower back pain; neuralgia; muscle and rheumatic pain; painful menstruation; symptomatic treatment of colds and flu (to reduce elevated body temperature); to reduce elevated body temperature against the background of colds, flu and childhood infectious diseases (including chicken pox, mumps, measles, rubella, scarlet fever); for toothache (including teething), headaches, ear pain with otitis media and sore throat. Release forms Film-coated tablets 500 mg. Panadol Extra tablets. Oral suspension Children's Panadol Baby (sometimes mistakenly called syrup). Rectal suppositories 125 mg and 250 mg (for children). Instructions for use and dosage Pills For adults (including the elderly), the drug is prescribed 500 mg-1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours. Children aged 6-9 years are prescribed 1/2 tablet 3-4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose for children 6-9 years old is 1/2 tablet (250 mg), the maximum daily dose is 2 tablets (1 g). Children aged 9-12 years are prescribed 1 tablet up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (1 tablet) can be taken no more than 4 times (4 tablets) within 24 hours. The drug is not recommended for use for more than 5 days as an analgesic and for more than 3 days as an antipyretic without a doctor’s prescription and supervision. Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician. Extra Adults (including the elderly) and children over 12 years of age are prescribed 1-2 tablets 3-4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets. Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician. Suspension or syrup The drug is taken orally. The contents of the bottle should be shaken well before use. The measuring syringe placed inside the package allows you to dose the drug correctly and rationally. The dose of the drug depends on the age and body weight of the child. For children over 3 months of age, the drug is prescribed 15 mg/kg body weight 3-4 times a day, the maximum daily dose is no more than 60 mg/kg body weight. If necessary, you can take the drug every 4-6 hours in a single dose (15 mg/kg), but no more than 4 times within 24 hours. Duration of use without consulting a doctor: to reduce temperature - no more than 3 days, to reduce pain - no more than 5 days. In the future, as well as in the absence of a therapeutic effect, you should consult a doctor. Rectal suppositories Orally or rectally in adults and adolescents weighing more than 60 kg, use a single dose of 500 mg, frequency of administration - up to 4 times a day. The maximum duration of treatment is 5-7 days. Maximum doses: single - 1 g, daily - 4 g. Single oral doses for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg/kg. Single doses for rectal use in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg. The frequency of use is 4 times a day with an interval of at least 4 hours. The maximum duration of treatment is 3 days. Maximum dose: 4 single doses per day. Side effect skin rashes; Quincke's edema; leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia; dyspeptic disorders (including nausea, epigastric pain); sleep disturbance; tachycardia. Contraindications severe liver dysfunction; severe renal dysfunction; arterial hypertension; glaucoma; sleep disorders; epilepsy; neonatal period; children under 12 years of age (for Panadol Extra); hypersensitivity to the components of the drug. Use during pregnancy and breastfeeding The drug should be used with caution during pregnancy and lactation. special instructions In cases of long-term use in high doses, monitoring of the blood picture is necessary. To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption. Patients suffering from atonic bronchial asthma and hay fever have an increased risk of developing allergic reactions. May change the results of doping control tests for athletes. Drug interactions When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. The drug enhances the effect of MAO inhibitors. Barbiturates, phenytoin, ethanol (alcohol), rifampicin, phenylbutazone, tricyclic antidepressants and other stimulants of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe intoxication with small overdoses. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity. Under the influence of paracetamol, the elimination time of chloramphenicol increases 5 times. Caffeine accelerates the absorption of ergotamine. The simultaneous use of paracetamol and alcoholic beverages increases the risk of developing hepatotoxic effects and acute pancreatitis. Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the effectiveness of uricosuric drugs. Analogues of the drug Panadol Structural analogues of the active substance: Akamol Teva; Aldolor; Apap; Acetaminophen; Daleron; Children's Panadol; Children's Tylenol; Ifimol; Calpol; Xumapar; Lupocet; Mexalen; Pamol; Panadol Junior; Panadol tablets, soluble; Paracetamol; Paracetamol (Acetophene); Paracetamol for children; Paracetamol syrup 2.4%; Perfalgan; Passer; Children's walker; Sanidol; Strimol; Tylenol; Tylenol for babies; Febricet; Cefekon D; Efferalgan. If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect. Panadol is a drug that has a non-steroidal, antipyretic, anti-inflammatory effect on the patient’s body. The action of the active component of paracetamol is aimed at lowering high body temperature and providing an analgesic effect. Thanks to the large number of available forms, the medicine can be taken not only by adults, but also by infants from the first month of life. The shelf life depends on the form of release. On average it ranges from 3 to 5 years. The main storage conditions for the tablet form are maintaining a temperature of up to 30 °C, syrup - up to 25 °C, rectal suppositories (suppositories) up to 20 °C. Release form Panadol comes in several forms. The tablets are white and coated. They should be taken exclusively orally. Each blister contains 12 tablets. One tablet contains 500 mg of paracetamol. Suspension (syrup) is intended for children from 6 months. Available in a glass bottle, the volume of which is 50 ml or 100 ml, with Raspberry flavoring. Five ml of suspension contain 120 mg of paracetamol. Rectal suppositories are intended for children from 6 months. Available with 125 mg and 250 mg of paracetamol in each suppository. The package contains 10 pieces. Effervescent tablets Panadol Soluble are intended for making a solution. Each tablet contains 500 mg of paracetamol, a total of 12 pieces per pack. Pharmacological properties The drug Panadol is a non-steroidal, non-selective, anti-inflammatory drug. The active ingredient paracetamol has a pronounced analgesic and antipyretic effect. When taken, due to a decrease in the activity of the cyclooxygenase enzyme, the synthesis of prostaglandins is inhibited. The antipyretic and analgesic result is caused by a decrease in the amount of prostaglandins in the central nervous system. The anti-inflammatory effect is slightly expressed due to the fact that paracetamol is deactivated by cellular peroxidases. Additional substances included in Panadol: corn and pregelatinized starch, potassium sorbate, povidone, stearic acid, triacetin, talc, hypromellose. Panadol Active, which contains bicarbonate, accelerates the absorption of paracetamol, which ensures the fastest possible therapeutic effect. Panadol Extra has an additional component - caffeine, due to which the therapeutic effect occurs faster. Approved for use only by adults and children over 12 years of age. After oral administration, the drug is quickly absorbed into the gastrointestinal tract, the maximum plasma concentration is observed within 30–120 minutes. Panadol acts 30–40 minutes after use, and the temperature will decrease faster if you take the medicine orally; if administered rectally, the temperature decreases slowly, but the effect lasts longer. Metabolized by the liver. It is excreted by the kidneys after 2–3 hours. Indications for use The medicine helps eliminate pain of various etiologies: migraine; headaches; toothache; muscle pain; rheumatic pain; neuralgia; algodismenorrhea. The Panadol tablet should be swallowed without chewing, with a sufficient amount of water. Place the effervescent tablet in a 100 ml glass of water. Syrup for children should be taken with water or juice. If necessary, you can dilute it in a small amount of water. Suppositories are used rectally. An interval of 4 hours must be maintained between doses of the medication. Panadol basic instructions for use. Use of Panadol in tablet form. An adult or child over 12 years of age should take a one-time dose of 500 or 1000 mg, which is equivalent to one or two tablets. The maximum dose allowed for use throughout the day is 4000 mg (8 pieces). For children from 6 to 12 years of age, the recommended dose for a single dose is 250–500 mg (0.5 or 1 tablet). The daily dosage should not be higher than 2000 mg. Use of Panadol in the form of Syrup. A single dose for children from six months to one year is from 60 to 120 mg of paracetamol, which is equivalent to 0.5–1 teaspoon of suspension. From 1 year to 3 years from 120 to 180 mg, corresponding to one or 1.5 teaspoons; from 3 to 6 years from 180 to 240 mg of paracetamol (2–3 teaspoons); from 6 to 12 years from 240 to 360 mg of paracetamol (3–5 teaspoons); children over 12 years old: 360 to 600 mg of paracetamol (3–5 teaspoons). Use of Panadol Baby rectal suppositories. The dosage will depend on the child's body weight. Per 1 kg of body weight there are 10–15 mg of paracetamol. Use as needed, maintain an interval of 4–6 hours, 3 to 4 times a day. The daily dose should not be higher than 60 mg per 1 kg of actual weight. For children weighing from 8 to 12.5 kg, administer one 125 mg suppository every 4–6 hours, 3–4 times a day. It is forbidden to use more than 4 suppositories per day. Taking Panadol to normalize body temperature and relieve pain is allowed for no longer than 3 days in a row. If the patient's condition has not improved, a doctor's consultation is necessary. Contraindications, overdose and side effects The main contraindications include individual intolerance to one of the components of the drug. For each age category, it is necessary to use a special dosage form (tablets, syrup, suppositories). Use with caution for viral hepatitis, kidney and liver failure, alcoholism, and the elderly. Contraindicated for: individual intolerance; hyperbillirubinemia; dysfunction of the liver and kidneys; hematopoietic disorders (leukemia, anemia); Panadol Soluble is prohibited for use in children under 6 years of age; Panadol Active is prohibited for use by children under 12 years of age. There were practically no side effects when the dosage was strictly observed. Possible adverse reactions in the form of itching, rashes, swelling, renal colic, anemia, interstitial nephritis. Symptoms of overdose appear in the interval from 6 hours to 4 days, in the form of gastrointestinal upset, profuse sweating, weakness, arrhythmia, convulsions, and respiratory depression. During pregnancy and lactation Panadol should be taken with caution and only as prescribed by a doctor during pregnancy and breastfeeding. It does not have a mutagenic effect, penetrates the placental barrier, and is excreted in mother's milk. It is necessary to use the medicine when the benefit to the mother outweighs the possibility of negative effects on the child. Drug interactions The combination of Paracetamol and non-steroidal anti-inflammatory drugs increases the risk of developing renal necrosis or failure, nephropathy. Diflunisal increases the concentration of the drug by 50%, which leads to hepatotoxicity. Myelotoxic medications, when combined with Panadol for a long time, increase the risk of bleeding. The combination of paracetamol and ethanol provokes the development of acute pancreatitis. Analogs Panadol has a lot of analogues, one of the cheapest and most accessible is Paracetamol. For children, you can replace it with Cefekon, Children's Panadol, Tylenol. For adults, take Efferalgan, Perfalgan, Ifimol. Efficiency and reviews Paracetamol is highly effective, has a rapid analgesic and antipyretic effect. Thanks to various release forms, it can be used to treat both very young children and adult patients. The main thing is to adhere to the dosage and the required interval between taking Panadol. The effectiveness will be confirmed by customer reviews. Nina, Irkutsk: “I work as a manager in a large company, I have to go on business trips very often. Climate change often affects health. A runny nose, sore throat and fever appear. It's very difficult for me to take regular pills. That's why I buy Panadol dissolvable tablets. Very convenient, put it in water, it dissolved and drank without difficulty. The temperature begins to drop within 30 minutes, which is very important when you need to meet with business partners. Panadol has always helped me out, so it’s always in my travel bag.” Article rating: (No ratings yet) Loading... Share with friends: Related publications Managing payment requests An investor acquires a company III Interregional Conference "Entrepreneurship in Industry: Paths of Development" Definition from regulations Benefits for paying customs duties