What kind of drug is methenamine and how does it help with sweating. Chemical transformations of methyl pheophorbide (a). Duff's reaction

Prescribed medicine for inflammatory processes in the kidneys and urinary tract:

• Cystitis
• Pielite.

Since the medication effectively treats sweat, Urotropin is used to treat sweating of the armpits, legs, and palms. It is also often used for intoxication. The drug removes toxins and quickly eliminates the symptoms of poisoning.

In addition, "Urotropin" is used in veterinary practice, in the treatment of inflammatory pathologies of the urinary system in cattle.

Compound

The drug contains the main active ingredient methenamine, and water for injection is used as an additive.

Medicinal properties

“Hexamethylenetetramine” (hexamethylenetetramine) is classified among a number of synthetic antiseptics, and is used both in medicine and as a veterinary drug, as well as in the chemical industry and the national economy (in this case, “Urotropin technical”, GOST 1381-73 is used).

Hexamethylenetetramine is produced by condensing formalhehyde and ammonia using a special formula. After the end of the chemical reaction, a certain mixture appears, which is filtered and evaporated until a slurry is formed. As a result, crystals are formed, which are recrystallized from alcohol. For medical purposes, use "Urotropin" of the highest grade, grade C, which meets the standards of the State Pharmacopoeia.

The medication has an antimicrobial effect and also produces a significant anti-inflammatory effect. Hexamethylenetetramine is highly effective and is a safe medicine. The properties of the drug make it possible to use it for many diseases. In particular, "Urotropin" has an active effect in the formation of pathologies of the urinary tract, since its mechanism of action occurs in an acidic environment. In addition to its antibacterial properties, Urotropin has a diuretic effect, which helps remove toxic substances from the body and also effectively eliminates sweating. The substance is broken down in the kidneys and in areas of inflammation. Hexamethylenetetramine is excreted in the urine.

The average price is from 30 to 60 rubles.

Solution for injections “Urotropin”

Solution for injection 40%, is a clear, odorless liquid, in glass ampoules of 5 and 10 ml. 10 ampoules are in a cardboard package, along with an annotation.

Mode of application

The medication is used for intravenous injection, 5-10 ml of a 40% solution. The dosage and treatment regimen are prescribed individually for each patient by the attending physician, taking into account age, weight and severity of the disease.

The average price is from 200 to 600 rubles.

Powder of “Hexamethylenetetramine” (hexamethylenetetramine)

The powder is white in color, without any particular odor, and has a sweetish-burning taste, turning bitter. It dissolves well in water and alcohol. Packaged in special bags.

Average price from 120 to 370 rubles.

Urotropin tablets

Hexamethylenetetramine tablets are produced in 0.25 g and 0.5 g, offered in special transparent glass tubes of 10 pieces. They are white in color, have a slightly bitter taste, and dissolve well in liquid.

Method of use of tablets and powder

For diseases of the urinary system, tablets should be taken orally at 0.5-1.0 g (1-2 tablets) twice a day, washed down with water, for 7-10 days. The children's norm is 0.1-0.5 g, before meals, 2 times a day. The exact dose should be checked with a specialist.

Treatment of sweating feet and armpits

Moreover, hexamethylenetetramine is effective for excessive sweating of the feet and armpits. When using the medicine to eliminate sweat in the armpits, follow some steps. First of all, you need to thoroughly wash your armpits using tar soap. Then apply the product to dry skin with a cotton pad. This procedure can be repeated no more than once every two weeks, preferably before bedtime. To avoid irritation of the armpits, do not use the product after shaving. If the skin of the armpits is excessively sensitive, hexamethyltetramine can be diluted with a small amount of water.

For sweaty feet, the use of the drug is similar. It is necessary to apply "Urotropin" only to clean, dry feet. Carefully treat the entire surface of the feet and the area between the toes, then put on cotton socks. If there are any injuries on the surface of the legs, do not use the drug until they are completely healed. Do not apply too much methenamine, as it can dry out the skin of your feet. Thus, the proposed treatment will help get rid of sweat formation for a long time. After a few weeks, the procedure can be repeated.

To consolidate the result, you should also follow several recommendations: maintain hygiene, take a warm shower, wear clothes made from natural materials that allow your armpits to breathe, and choose high-quality shoes.

Contraindications and precautions

Hexamethylenetetramine has no special contraindications; almost the only one is increased susceptibility to methenamine.

If hematuria or proteinuria develops during therapy, treatment should be discontinued.

It is also worth remembering that taking medication and alcohol together is possible, however, in order to avoid increased acidity of urine, it is better to avoid taking drinks containing alcohol.

Pregnancy and breastfeeding

The effect of the drug during pregnancy and breastfeeding is unknown; it would be correct to refrain from using it during this period.

Interaction with other drugs

The effect of the drug with other medications is not known.

Side effects

The most likely adverse reactions may occur as:

• Skin rashes
• Frequent urination
• Hematuria.

Overdose

In case of overdose, the following symptoms are most often diagnosed:

• Unpleasant sensations in the urethra, manifested by itching and burning
• Urinary tract irritation
• Hematuria
• Urinary dysfunction
• Allergy formation.

Conditions and shelf life

Store hexamethylenetetramine solution for injection, as well as tablets and powder, in a dry and dark place. Recommended shelf life is 2 years.

Analogs

Rosbio LLC, Russia, etc.
Price from 400 to 450 rub.

The drug is an antiseptic and disinfectant and is presented in the form of a solution. Mainly used as an antimicrobial agent for diseases of the genitourinary system, for treating the skin, oral cavity, etc.

pros

• Has a powerful antibacterial effect
• Long lasting action

Minuses

• Sometimes an allergic reaction occurs
• Use with extreme caution in pediatrics.

Rosbio/Yuzhfarm, Russia
Price from 15 to 200 rub.

The medication has a beneficial effect on the condition of the urinary system and is an excellent means for the prevention of diseases such as cystitis, urethritis, prostatitis, etc. It enhances the effect of antimicrobial agents. Available in capsule and powder form.

pros

• Has an antioxidant effect.
• Non-addictive

Minuses

• Do not use for acute gastrointestinal diseases
• Do not take during pregnancy or breastfeeding.
• Sometimes causes an allergic reaction.

Chemical formula: C 6 H 12 N 4.

It is obtained by the method of contact transformation of methanol into formaldehyde, which reacts with ammonia in the liquid phase to form hexamine crystals, followed by its isolation by methods of precipitation and centrifugation, drying and stabilization with silicon dioxide.

Technical methenamine is used in the production of plastics, synthetic rubber, varnish films; in analytical chemistry for the preparation of buffer solutions, for microcrystalscopic discovery of a number of ions; in the production of explosives (raw materials for the production of hexogen) and hexamethylene triperoxide diamine; as a corrosion inhibitor.
It is used in medicine as a medicine (antiseptic) for the treatment of the urinary tract and as an anti-influenza agent.
In the food industry, hexamethylenetetramine is used as a preservative additive E239. Often used in cheese making, as well as for preserving red caviar.
In everyday life it is used as a dry fuel (“dry alcohol”) for cooking (warming) food, for lighting and calcining stoves, warming cellars, garages, etc.

Depending on the purpose, technical urotropine is produced in the following brands:
K - coarse-crystalline;
C - with different crystal contents (polydisperse);
M - fine-crystalline.

Safety requirements for technical hexamine.
Technical methenamine is a flammable substance, and according to the degree of impact on the body, it belongs to substances of the 3rd hazard class. When it comes into contact with the skin, methenamine has a highly irritating effect, sometimes causing eczema with severe itching, which quickly disappears after stopping working with it.
When working with methenamine, special clothing, safety shoes, gloves, and personal respiratory protection are used. The skin must be protected with protective ointments.
The maximum permissible concentration of dust in the air of the working area of ​​industrial premises is 9 mg/m³.
A flammable substance, settled dust is a fire hazard. Aerosol is explosive. The self-ignition temperature of the airgel is 343° C. Extinguish - with sprayed water or foam.
Work with technical hexamine should be carried out in rooms equipped with supply and exhaust and local ventilation.

Packaging, transportation and storage.
Technical grade K hexamine is packaged in polyethylene or polyvinyl chloride bags, enclosed in four- or six-layer unimpregnated paper bags, or in open five-layer paper glued bags with two layers laminated with polyethylene. Net weight - 50 kg.
Technical grade C hexamine is packaged in five- and six-layer bitumenized paper bags, in which the inner layer should not be bitumenized; two four-layer unimpregnated paper bags, nested one inside the other; laminated bags; film liner bags or polyethylene bags placed in three-layer paper bags. Net weight - 50 kg.
Technical grade M methenamine is packaged in polyethylene bags placed in plywood drums or vinyl leatherette bags. Net weight - 20 kg.
Technical hexamine is transported by any type of transport in covered vehicles in accordance with the rules for the transportation of dangerous goods in force for this type of transport.
Technical methenamine is stored in dry warehouses.

In the modern world, absolutely every person has at least once suffered from some kind of infectious disease caused by a certain pathogenic microorganism. One of the most common locations of bacteria in the human body is the urinary system. When these organs are damaged, unpleasant symptoms occur such as:

If one or more of the listed symptoms occurs, you must immediately contact a urologist, who will prescribe the appropriate tests and provide the necessary treatment.

For example, Urotropin is often used in such cases. What kind of drug this is, what its formula is, and what is included in Urotropin will be discussed in detail below.

Description

The drug, which is produced by the Russian plant OJSC Metafrax, located in the Perm region, the city of Gubakha, has a substance called methenamine as its main active ingredient.

Externally, it is a powder consisting of white rhombic crystals, and also has a slight specific odor and sweet taste.

A characteristic feature of the drug is its rich history of use in medicine. It dates back about a hundred years, that is, for about a century the drug has been helping to effectively cope with some ailments.

Formula

"Urotropin" by its chemical nature belongs to the class of polycyclic amines. These are organic substances that contain several benzene rings, as well as nitrogen atoms.

The full name of the chemical formula of "Urotropin" is 1,3,5,7-tetraazotricyclo-decane.

If we talk about how the nitrogen atoms included in the drug molecule are located, their arrangement is as follows.

This is called the structural formula of "Herotropin", looking at which you can clearly see how the nitrogen atoms are connected to each other by carbon bonds.

However, it often happens that such spellings of a substance are not always convenient. Therefore, the short formula of “Urotropin” is often used - C 6 H 12 N 4.

Thus, methenamine consists of carbon and hydrogen atoms. In addition, the formula of "Urotropin" includes four more nitrogen atoms.

Components of the drug

Most often in medical and veterinary practice, an injection solution is used. Next, we will analyze in more detail the composition of "Urotropin".

Instructions for use indicate what it contains:

• Methenamine is the active substance.
• Water for injection - as a solvent.

Release forms

On the pharmaceutical market the drug is presented in several forms:

1. Injection solution for intravenous administration, having a concentration of 40%.
2. Powder, which is packaged in bags.
3. Tablets of 0.25 and 0.5 g.

Indications for use

"Urotropin" is a universal drug. In addition, it has a fairly diverse list of conditions for which its use is relevant. These include:

• Infectious diseases of the urinary system (cystitis, pyelitis, pyelonephritis).
• Hyperhidrosis. The drug is effectively used to eliminate sweating of the armpits, palms and feet.
• "Urotropin" is widely used in veterinary medicine. Possessing an anti-inflammatory effect, it is able to quickly eliminate diseases of the kidneys, bladder, and mammary glands in cattle.

Contraindications for use

Like any other drug, Urotropin has a number of contraindications, namely:

• Children's age up to 6 years.
• Individual intolerance to the drug.
• Kidney or liver failure.
• Dehydrated state of the body.

Use during pregnancy and breastfeeding

There is no scientifically proven data on the safety of use by women during this period, so it is better for this group of people to refrain from treatment with Urotropin.

Side effects

In some cases, "Urotropin" can have a negative effect on the body, especially on the function of the kidneys and bladder.

The main unwanted side effects are as follows:

• An allergic reaction in the form of an itchy rash on the skin. This symptom disappears quickly and without a trace after stopping the drug.
• Hematuria is the appearance of blood in the urine.
• Proteinuria is the appearance of protein in the urine.
• Frequent urination.

If such negative reactions occur, you must immediately consult a doctor in order to decide whether to stop treatment with Urotropin or adjust its dosage.

Storage conditions

The drug should be stored in a dry place, at a temperature not exceeding 25 degrees, away from sunlight and out of reach of children.

Conditions for dispensing from pharmacies

"Urotropin" is a prescription drug, so it is not freely available. When selling it, the pharmacist (or pharmacist) will definitely ask for a prescription form, which must be prescribed by the attending physician.

Cost of medicine

"Urotropin" (formula C 6 H 12 N 4) is a cheap drug. Its cost does not exceed 100 rubles per package.

Conclusion

"Urotropin" is a unique drug with a wide spectrum of action.

The main advantages of the drug are its low cost, as well as its high efficiency, time-tested.

The disadvantage is the presence of a whole list of side effects, due to which some patients have to stop the course of treatment with Urotropin and again contact the doctor to change the medication.

It should be remembered that the product can negatively affect the body, so it is unacceptable to use it independently without a doctor’s prescription.

Urotropine is available in the form powder , tablets or solution for injection with different contents of active substance. The drug can be packaged in vials, ampoules or bags.

pharmachologic effect

The drug has significant antimicrobial And anti-inflammatory action.

Pharmacodynamics and pharmacokinetics

According to Wikipedia, urotropine and its main analogue is a synthetic drug used in clinical practice for more than 100 years. This drug is characterized by antiseptic effect , predominantly manifested in the urinary tract. Hexamethylenetetramine included in various medications that can be administered orally or intravenously.

It should be noted that such a substance as Hexamethylenetetramine , being highly effective, it is relatively safe. The fact is that the mechanism of its action is splitting with the release of active , occurs only in an acidic environment. At the same time, the drug acts on bacteria that cause diseases of the urinary tract, foci of inflammation with a high content of acidic tissue breakdown products.

Also, methenamine is characterized by a diuretic effect, increasing the permeability of cell membranes, which accelerates the removal of toxins from the living body. The drug and it are excreted in urine 40-60 minutes after administration, and this process continues for about 6-12 hours.

Indications for use

The main indications for prescribing Urotropin are infectious and inflammatory diseases developing in the urinary tract:

• pyelitis.

This drug is also actively used in veterinary practice as antitoxic , antimicrobial And diuretic means for the treatment of inflammatory processes in the kidneys, bladder and urinary tract in large animals. Urotropine helps with and toxic infections , neutralizing and quickly eliminating toxins from the body. The drug is included in the complex therapy of endometritis and mastitis in cows.

Additionally, this remedy can be used on the palms, legs, and armpits of people.

Use of Hexamine for sweat

The problem of sweating is one of the most acute. In addition to the unpleasant sensations and smell of wet shoes and clothes, a significant number of bacteria and fungi develop that affect the condition of the skin. To solve this problem, many modern products have been created - creams, gels, ointments, antiperspirants, and so on. However, Urotropin will help eliminate sweating for a longer period, namely 15-30 days, but you should not use a technical preparation.

To eliminate sweating, use the product in powder or liquid. It is methenamine in ampoules that is rarely found in pharmacies, so you can use 5% Hexamethylenetetramine . This method is usually used for sweating of the feet, in rare cases in the armpits.

It is better to perform the procedure before bedtime. Before applying the drug, you need to thoroughly wash and dry your armpits, which should be shaved in advance so that the cuts have time to heal. Then, using a cotton swab, you need to apply the solution to the prepared area of ​​skin, put on underwear made of natural material and you can go to bed. It is recommended to take a contrast shower in the morning. Urotropin should be applied to the armpit area once every 2 weeks. Additionally, you can use antimicrobial soap.

As a rule, use for sweating feet involves applying the drug to the feet. In this case, you must first consult with a specialist. To treat sweaty feet, 40% Watropin is used. The treatment procedure includes thoroughly washing the feet with antibacterial soap, then dry the feet and apply the prepared solution to the feet and the skin between the toes. After this, they put on clean, dry socks and go to bed. In the morning, rinse your feet with warm water from the shower. Additionally, the use of talc is allowed.

By the way, before using this method of treating sweating, you need to get rid of fungal infection, wounds, cracks and other defeats. You also need to keep your socks and shoes clean.

Contraindications for use

special instructions

Sometimes when using this drug, symptoms appear. hematuria or requiring discontinuation of treatment.

Side effects

When treated with Urotropin, it may develop hematuria, proteinuria , skin rash, increased urination.

Instructions for Urotropin (Method and dosage)

According to the instructions for use of Urotropin, the drug is intended for intravenous administration. In this case, the dosage, regimen and duration of therapy are established by the doctor, since this requires taking into account the age and weight of the patient, as well as the nature and severity of the disease. Moreover, urinary tract infections often require additional medications and procedures.

Overdose

In cases of overdose, undesirable effects may develop such as: itching, burning And irritation urinary tract and urethra, dysuric manifestations, hematuria , other manifestations .

Interaction

Drug interactions of this drug with other drugs that have a significant clinical effect have not been described.

Terms of sale

Urotropine is available by prescription.

Storage conditions

The medicine should be stored in a cool, dry, fairly dark place, out of reach of children.

Best before date

Analogues

The main analogues of Hexamine are represented by the following drugs: Hexamethylenetetramine, Hexamine, Methenamine And Urizol .

Alcohol

There is no direct contraindication to the simultaneous use of this drug and alcohol, but since alcohol-containing substances increase the acidity of urine, it is better to avoid using them during treatment.

Instructions for use of the drug Urotropin as an antibacterial,
antitoxic and diuretic agent for cattle and pigs
(developer organization: Mosagrogen CJSC, Moscow)

I. General information
Trade name of the drug: Urotropine.
International nonproprietary name: methenamine (hexamethylenetetramine).

Dosage form: solution for injection.
Hexamethylenetetramine in 1 ml contains as an active ingredient: hexamethylenetetramine - 400 mg, as well as water for injection.
In appearance, the drug is a clear, colorless liquid.

Hexamine is produced packaged in 10, 20 and 100 ml glass bottles of appropriate capacity, sealed with rubber stoppers reinforced with aluminum caps.

Store the medicinal product in the manufacturer's sealed packaging in a dry place, protected from direct sunlight, separately from food and feed, at a temperature of 5°C to 25°C.
The shelf life of the medicinal product, subject to storage conditions, is 2 years from the date of production. It is prohibited to use the drug after its expiration date. Should be kept out of the reach of children.
Unused medicinal product is disposed of in accordance with legal requirements.

II. Pharmacological properties
Hexamine belongs to the pharmacotherapeutic group of antibacterial drugs for systemic use.
It has a diuretic effect, increases the permeability of cell membranes, thereby accelerating the removal of toxins from the body. In an acidic environment, especially in the kidneys and urinary tract, hexamethylenetetramine breaks down into formaldehyde and ammonia, which exhibit an antibacterial effect.
The excretion of hexamethylenetetramine and its metabolites in the urine begins 40-60 minutes after administration and continues for 6-12 hours.

In terms of the degree of impact on the body, methenamine is classified as a low-hazard substance (hazard class 4 according to GOST 12.1.007-76).

III. Application procedure
Hexamine is used as an antibacterial, antitoxic and diuretic agent for inflammation of the kidneys, bladder and urinary tract in cattle and pigs.
The drug is used for intoxication and toxic infections in order to accelerate the removal of toxins from the body. Hexamine is also used in complex therapy in the treatment of endometritis and mastitis with signs of intoxication in cows.

Contraindications for use are hypersensitivity to hexamethylenetetramine, dehydration, renal and liver failure, pregnancy.

Hexamine is used intravenously (in pigs into the ear vein) 2-3 times a day in the following doses:

• cattle: 1.5-2 ml per 10 kg body weight,
• pigs: 0.5-0.7 ml per 10 kg body weight.

The duration of use depends on the nature and severity of the disease, but should not exceed 4 days.

No overdose symptoms were identified.
The specific effects of the drug upon its first use and upon its withdrawal have not been established.
Avoid skipping the next dose of the drug, as this may lead to a decrease in therapeutic effectiveness. If one dose is missed, the drug must be administered as soon as possible.
When using Hexamine in accordance with these instructions, side effects and complications in farm animals, as a rule, are not observed.
The use of Hexamine does not exclude the use of other medications.

In the urinary tract of cattle, the effect of hexamethylenetetramine is less pronounced due to the alkaline reaction of urine. In this case, it is necessary to prescribe substances that shift the urine reaction to the acidic side, for example, ascorbic acid.

After using Hexamine, animal meat can be used for human food no earlier than 24 hours later.
The meat of animals forcedly killed before the expiration of the specified period can be used to feed fur-bearing animals.
The use of milk for human consumption is permitted one day after the last administration of Hexamine.
Milk obtained from cows during treatment is used as animal feed after boiling.

IV. Personal prevention measures
When working with Hexamine, you should follow the general rules of personal hygiene and safety precautions provided for when working with medications. After finishing work, wash your hands with warm water and soap.
In case of accidental contact of the drug with the skin or mucous membranes of the eye, they must be rinsed with plenty of water. People with hypersensitivity to the components of the drug should avoid direct contact with Urotropin. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug or the label).

Empty drug bottles must not be used for household purposes; they must be disposed of with household waste.

Manufacturer: JSC "Mosagrogen"; 117545, Moscow, 1st Dorozhny proezd, 1.

With the approval of this Instruction, the Instructions for the use of Hexamine as an antitoxic, antiseptic and diuretic agent for cattle and pigs, approved by Rosselkhoznadzor on December 29, 2006, become invalid.