Adilin is used for the slaughter of stray animals legally and does not cause suffering to the animals. Without trial "Adilin" as one of the muscle relaxants

MINISTRY OF AGRICULTURE OF THE RF
DEPARTMENT OF SCIENTIFIC AND TECHNOLOGICAL POLICY AND EDUCATION
FSBEI HPE DON STATE AGRICULTURAL UNIVERSITY

About the use of the drug "Adilin"

Adilin belongs to the “muscle relaxants” group of drugs, the mechanism of action of which in small doses is a reversible short-term immobilization of the body due to a depolarization disorder in the transmission of excitation from the motor nerves to the muscle fibers of skeletal muscles. Muscle relaxants are widely used both in veterinary practice (Rompun, Rometar, etc.) and in medical practice (Ditilin, Listenone, etc.) - for controlled immobilization of patients in depth and duration during diagnostic and therapeutic procedures that cause a defensive reaction (introduction probes, reduction of dislocations; restoration of the relative position of bone fragments and other surgical operations). Unlike narcotic drugs, depolarizing muscle relaxants do not cause side effects, since in the process of their metabolism non-toxic products are formed, which are already constantly present in the body - choline and succinic acid. The drug has an effect only when administered parenterally (not through the digestive tract).
When high doses of the drug are used, it causes the death of the body, and it has been established that bioelectrical activity of the brain fades before cardiac activity stops, which is the direct cause of death of the body, occurring 15...60 seconds after the administration of the lethal dose of the drug recommended by the regulatory framework of the Russian Federation. Paralysis of the respiratory muscles against the background of cardiac arrest practically no longer plays any pathogenetic role. Thus, we can confidently say that the moment of death comes unnoticed by the brain.
The above was the basis for recommending Adilin as a humane means for the bloodless slaughter of animals. However, with such slaughter, the carcass is not bled and the sanitary standards in force in Russia do not allow the use of the drug for slaughtering animals for meat used for human consumption, therefore, according to the regulatory framework of the Russian Federation, the drug is intended for the slaughter of only fur-bearing animals, dogs and cats ("Temporary Instruction" on the use of Adilin-super for the slaughter of fur-bearing animals, cats and dogs" approved by the Main Directorate of Veterinary Medicine with the State Veterinary Inspectorate on April 24, 1991 - copy attached), as well as for forced slaughter, with subsequent destruction or disposal of corpses, cattle, pigs, sheep , rabbits, deer and poultry ("Instructions for the use of Adilin for bloodless slaughter of animals"; approved by the Federal Service for Veterinary and Phytosanitary Surveillance in 2008; registration No. PVR-2-7.7/02169 - copy attached).
The above gives us grounds to respond to the essence of your request: the use of pharmacological agents “Adilin”, “Adilin-super” and other xylazine-containing drugs for slaughter of animals is not inhumane, since it does not cause suffering to the animal. Their use for the capture and euthanasia of stray animals does not contradict the legal framework of the Russian Federation, since it is prescribed by the above-mentioned legal acts.

Head Department of Anatomy, Physiology of Domestic Animals, Biology and Histology, Professor V.Kh. Fedorov
Associate Professor of Animal Physiology Course V.S. Stepanenko
Associate Professor of the course of pharmacology and toxicology N.V. Sumin

The Verkh-Isetsky District Court of Yekaterinburg considered the claim of the prosecutor of the Verkh-Isetsky district to recognize the illegal activities of the EMUP "Spetsavtobaza" in the use of the drug "Adilin-super" and its analogues for the capture of stray animals.

The basis for the prosecutor's filing of this claim with the court was the results of an inspection carried out at the request of the management of the Charitable Fund for Helping Homeless Animals. During the inspection, it was established that the killing of stray animals (in particular, dogs) is carried out by specially created teams (catchers) using the drug “Adilin-super”, as a result of which the animal dies a painful death from suffocation, which is extremely inhumane.

In addition, when carrying out activities to catch stray dogs, the enterprise EMUP "Spetsavtobaza" does not comply with the established rules for catching stray animals, since before destruction the dogs are not placed in a shelter, through which they could subsequently be returned to their lost owners.

Based on the results of the inspection, the prosecutor filed a lawsuit to recognize the illegal activities of EMUP "Spetsavtobaza" in the use of the drug "Adilin-super" and its analogues and to oblige the enterprise to create a shelter for captured stray and stray animals. The prosecutor's claims were satisfied by the court.

Help from the Animal Rights Protection Center “VITA”

Adilin-super and its analogues: ditilin, listenone:

• curare-like substances (curare poison is used by aboriginal Indian tribes of Latin America to brutally kill animals during hunting - arrows poisoned with poison are used);
• are widely and universally used by local city authorities in Russia to catch and kill stray animals (catchers use blowpipe or guns that shoot syringes);
• also used on fur farms as a supposedly humane killing of animals doomed to die for fur;
• It is also widely used in veterinary practice (both public clinics and private) for supposedly humane killing;
• causes a slow, painful death as a result of gradual paralysis of the respiratory muscles. those. the animal, being fully conscious, dies for a long time and extremely painfully, but outwardly it looks like falling asleep, which misleads inexperienced eyewitnesses, for example, animal owners who naively believe that they are alleviating the suffering of their terminally ill pet - a dog or cat;
• used in medicine and veterinary medicine for a number of diseases, but with mandatory ventilation
• in civilized countries, the use of curare-like drugs for killing animals is prohibited and criminalized;
• being potent drugs, they are used by catchers of stray animals - people of an openly marginal, carnivorous type, which poses a mortal danger not only for animals (catchers do not know who to shoot), but also for the health and life of people around them (tragic cases are known) . By a strange logic, they were ignored by the Drug Control Service (FSKN of Russia), which from the beginning was engaged in a fruitless hunt for ketamine “witches”, depriving Russian animals of pain relief during surgical operations, i.e. doomed animals to torture, and also subjected veterinarians who honestly performed their medical duty to absurd repressions
• All over the world, barbiturates are used to euthanize animals for veterinary indications, which turn off the animal’s consciousness and put it into deep sleep.

ON THE. Danilov, L.L. Matsevich, S.A. Arestov, E.N. Anashkina, V.A. Rybalko

1. General view of the situation

The most common way to regulate the number of stray animals in Russia over the past 20 years has been their remote killing (“shooting”) using “flying syringes” or darts containing curare-like muscle relaxants (ditylin, listenone; in recent years - adilin).

At the same time, as a rule, there is no practice of temporary holding of captured animals: killing is carried out right on the spot. This method is subject to severe criticism from the animal protection community, and in a number of regions has already come under a formal ban - either by court decisions citing its contradiction with certain federal legislative acts (for example, the Civil Code), or during the adoption of regional legislation that directly prohibits killing animals at the capture site. The effectiveness of this method is also limited - because it is not accompanied by additional measures to prevent homelessness, and also has low popularity among the population: people are often in no hurry to call catchers when in contact with stray dogs, feeling sorry for animals that are destined only for guaranteed death.

The reasons for the widespread practice of such shooting in Russia are as follows:

*lack of consistent federal legislation regulating the issues of catching, keeping and euthanasia of stray animals;

*reluctance of municipalities to organize catching in a truly civilized manner; * saving effort and money by the direct executors, including due to the scarcity of funds allocated (received) for catching, which is expressed, among other things, in the lack of equipped premises (temporary detention centers, shelters) to accommodate captured animals;

*absence in Russia of institutions for professional training of catchers and, accordingly, requirements from municipal authorities (as customers) for the mandatory availability of such training;

*the vicious practice of assessing the results of work and calculating the salaries of employees of catching services based on the number of heads not caught, but destroyed.

In this paper, we focus on one of the negative aspects of the use of curare-like muscle relaxants - the suffering of animals during killing.

2. General characteristics of muscle relaxants with curare-like action and their mechanisms of action

To clearly understand the mechanism of action of muscle relaxants, let us turn to brief information on neuromuscular physiology.

The neuromuscular junction is the connection between a nerve fiber and a skeletal muscle fiber. The transmission of a signal from a nerve to a muscle is carried out through the release of molecules of a special intermediary substance, acetylcholine, from the side of the nerve fiber. Acetylcholine then binds to the n-cholinergic receptor on the muscle cell membrane (“post-synaptic receptor”), causing a change in its state. The distribution of electrical charges outside and inside the muscle cell membrane changes (depolarization), generating a short-term drop in electrical potential that triggers the process of muscle contraction. For the next start of the muscle fiber contraction process, the charge state of the muscle membrane must be reset to its original state (repolarization). After contraction is activated, acetylcholine is very quickly (~0.001 s) destroyed by the enzyme cholinesterase, and the membrane is repolarized and becomes capable of receiving a new signal from the nerve fiber.

Muscle relaxants with curare-like action affect the process of signal transmission at the neuromuscular synapse. They are divided into depolarizing and non-depolarizing.

Non-depolarizing muscle relaxants (for example, tubocurarine) block the effect of acetylcholine on the n-cholinergic receptors of the muscle membrane, thereby preventing the passage of the signal that activates muscle contraction, but do not change the state of the receptor itself. Depolarizing muscle relaxants (ditylin, listenone) are similar in molecular structure to acetylcholine and act on receptors like acetylcholine, but are not broken down by the enzyme cholinesterase in the synaptic cleft, and therefore cause persistent depolarization of the muscle membrane, making it insensitive to the receipt of control signals. (The blood enzyme pseudocholinesterase gradually breaks down depolarizing muscle relaxants, neutralizing their effects, but this is a slow process.)

After injection, curare-like muscle relaxants cause relaxation and paralysis of muscles in the following sequence: facial muscles, muscles of the larynx (vocal cords), neck, muscles of the limbs, torso, and finally, muscles of the diaphragm responsible for breathing. When critical doses of muscle relaxants are administered, respiratory arrest is possible (in medicine, in this case, the patient is transferred to artificial ventilation) and subsequent death. Note that the direct effect of the drug entering the bloodstream on other vital organs (for example, the heart) is not a factor that can cause death.

3. Veterinary aspect of the use of muscle relaxants, the opinion of international and foreign organizations.

One of the most authoritative, accurate, and comprehensive sources describing the various methods of killing animals that are suitable and unsuitable for euthanasia of various species is the Guide to Euthanasia, developed by the American Veterinary Medical Association through an analysis and synthesis of existing scientific evidence. The last updated edition of the Guide was published in 2007; thus, these data are also the most up-to-date.

All substances acting as neuromuscular blockers (magnesium sulfate, nicotine, all curare-like muscle relaxants) are classified in this Guide as drugs, the use of which is permissible only after the animal has previously been immersed in a state of anesthesia. The use of neuromuscular blockers without prior anesthesia is absolutely unacceptable.

In scientific laboratory practice, the use of muscle relaxants for the euthanasia of animals, including dogs and cats, without prior anesthesia is also not allowed. This use of muscle relaxants is contrary to both the recommendations of the Humane Society International (HSI) and the European Convention for the Protection of Companion Animals (which prohibits the use of killing methods based on artificial cessation of respiration unless such methods cause immediate loss of consciousness or begin with immersion in deep anesthesia).

The reason for this conclusion is that these drugs lead to an excruciating feeling of suffocation, but at the same time they have neither narcotic nor sedative properties. The use of lethal doses of neuromuscular blockers causes paralysis of skeletal muscles, including the respiratory muscles. In a fully conscious animal, acute respiratory failure of neuromuscular etiology occurs.

At the same time, the use of muscle relaxants is inhumane even despite the fact that, starting from certain concentrations of carbon dioxide in the blood, the animal develops an unconscious state, and cardiac arrest occurs after the electrical activity of the brain has died down - since the increase in carbon dioxide concentration occurs too slowly. The accumulation of carbon dioxide when using muscle relaxants does not occur due to the chemical decomposition of the administered drug, but only due to the metabolic processes of the body itself (as in any other case of stopping the flow of air into the lungs). Metabolic processes do not proceed quickly enough to produce a high concentration of carbon dioxide in the blood in a period of time short enough for the animal not to have time to feel suffocated.

As a result, loss of consciousness and extinction of electrical activity of the brain when using muscle relaxants is preceded by a fairly long period (up to several minutes) when a fully conscious animal experiences painful suffocation. Thus, it can be argued that killing conscious animals with chicken-like muscle relaxants causes them suffering.

For comparison, we note: during inhalation euthanasia of animals with carbon dioxide, which is based precisely on the anesthetic effect of high concentrations of carbon dioxide, gas mixtures from cylinders with a carbon dioxide concentration of at least 70-80% are used so that the required concentration of carbon dioxide in the animal’s blood is achieved in the shortest possible time.

The statement that is sometimes found that the moment of death when using muscle relaxants occurs in the absence of sensitivity, imperceptibly for the body, in fact has nothing to do with the essence of the issue under consideration, since what is fundamentally important here is not the moment of death itself - but the processes occurring long before it, when the animal is still conscious. Paralysis of the respiratory muscles and suffocation occur until loss of consciousness and extinction of the electrical activity of the brain (and the subsequent cessation of cardiac activity).

4. "Adilin" as one of the muscle relaxants

We have at our disposal a number of documents that contain statements about the supposedly very rapid death of an animal after the administration of one of their muscle relaxants - namely, “Adilina” (which is produced by the Kazan association Vetbioservice LLC). Thus, in the conclusion on the use of the drug “Adilin”, provided by employees of the Federal State Budgetary Educational Institution of Higher Professional Education “Don State Agrarian University” V.Kh. Fedorov, V.S. Stepanenko and N.V. Sumin in 2012, it is noted that the period of death is 15-60 s after administration of the drug. However, such information is not confirmed by scientific sources; this period is attributed only to the stage of the beginning of relaxation of skeletal muscles. Moreover, the manufacturers of the drug themselves indicate the time of death to be about 1-3 minutes.

At the same time, we do not have access to any information confirming beyond any doubt that the mechanism of action of the drug “Adilin” is in any way different from the mechanism of action of other muscle relaxants. Moreover, the drug "Adilin" (bis-dimethyl sulfate of bis-dimethylaminoethyl ester of succinic acid) is a close chemical analogue of the drugs "Ditilin" (diiodomethylate of bis-dimethylaminoethyl ester of succinic acid) and "Listenon" (dichloromethylate of bis-dimethylaminoethyl ester of succinic acid), having curare-like properties, and inapplicable for humane euthanasia without first placing the animal under anesthesia.

Thus, there is every reason to classify the drug “Adilin” as a group of substances, the use of which for euthanasia is permissible only after the animal has been put into a state of anesthesia using certified veterinary drugs intended for this purpose - but in no case as the only means used.

On the other hand, we recognize the forced need to use euthanasia in the course of measures to regulate the number of stray animals. Russia is one of the countries with a “European style” of dog keeping (most dogs are owned, and stray dogs are their descendants). For such countries, the optimal basic method of working with existing stray dogs is irretrievable capture and subsequent placement in a municipal shelter.

From such a shelter, captured animals can be transferred for further maintenance to the previous owners, or to citizens and public organizations who have expressed a desire to become the new owners of the animal, and keep it in accordance with the current Rules for keeping pets. However, the period of keeping captured animals in a municipal shelter should be limited to a reasonable period, since the municipal shelter must be able to accept all stray animals subject to capture. Otherwise, the irrevocable capture of stray animals in the city will be paralyzed, and measures to regulate the number of stray animals will become ineffective.

According to the current legislation of the Russian Federation, for owned animals this period must be at least 6 months, since the acquisition of ownership of this type of property occurs precisely after the passage of such a period - however, for ownerless animals, the period of mandatory maintenance can be reduced, since the capture of such animals is carried out in order to regulate their numbers, and not to acquire ownership of them.

Therefore, if the number of animals returned to the previous owners and transferred to the new owners is less than the number of animals captured; or animals received from capture, due to behavioral characteristics or health conditions, cannot be transferred to new owners - there is a need to euthanize unclaimed animals. To eliminate the need for euthanasia of healthy animals, long-term work is required to prevent homelessness and neglect within the framework of an integrated approach, including the fight against excessive reproduction of domestic animals.

Although in Russia there are no certified veterinary drugs that can be used for humane euthanasia, carried out in one step, it remains possible to use euthanasia schemes that involve two stages:

a) putting the animal into a state of anesthesia using veterinary drugs certified for such use (for example, intramuscular injection of the drug “Zoletil” or its mixture with the drug “Xylazine”, or intravenous administration of the drug “Propofol”);

b) after this, administering to the anesthetized animal one of the drugs certified for use for the purpose of killing animals (for example, the drug “Adilin”);

6. Temporary immobilization during capture.

The use of the drug "Adilin" not for killing, but for temporary immobilization of animals also raises questions, since there are no official instructions regarding dosages for temporary immobilization of animals with this drug. Therefore, first of all, we propose to consider the possibility of using the drugs “Xylazine” (“Rometar”, “Xila” and other xylazine-containing drugs) and “Zoletil” (its mixtures with the drug “Xylazine”) for this purpose. This method of temporarily immobilizing dogs during capture is already used in a number of Russian cities (Moscow, St. Petersburg, Yaroslavl).

As for the use of muscle relaxants for temporary immobilization, in this case it is necessary to turn to the use not of Adilina, but of another drug - Ditilina, for which there are officially approved instructions for its use specifically for temporary immobilization. As for the use of the drug “Adilin” for this purpose, it seems to us that such a possibility can only be considered after the Ministry of Agriculture of the Russian Federation or other authorized executive body has developed and approved official instructions indicating the exact dosages of the drug, obviously not causing death.

In any case, the use of rapid-acting muscle relaxants should only be a last resort measure used to capture severely feral animals that cannot be captured using less dangerous means; In addition, teams of catchers using such muscle relaxants must carry injectable drugs that weaken the effect of the muscle relaxant (vitamin B1 - thiamine, as well as 0.1% solution of epinephrine in hypertonic sodium chloride solution), and be able to use them under appropriate circumstances.

1. W.F. Ganong. Neuromuscular junction, p. 53-54. In Ganong, W. F., Review of Medical Physiology. Lange Medical Publ., Los Altos, Calif. 577 pp. 1963

2. J. Appiah-Ankam, J. Hunter. Pharmacology of neuromuscular blocking drugs.//Continuing Education in Anaesthesia, Critical Care & Pain. Vol.4(1), p.2-7, 2004

3. Pharmacology // Ed. R.N. Alyautdina. - 2nd ed., rev. - M.: GEOTAR-MED, 2004. - 592 p.

4. AVMA Guidelines on Euthanasia. //American Veterinary Medical Association, June 2007. Document available at: https://www.avma.org/KB/Policies/Documents/euthanasia.pdf

5. Recommendations for euthanasia of experimental animals: Part 1.//Laboratory Animals, Vol.30, p.293-316, 1996

6. Recommendations for euthanasia of experimental animals: Part 2.//Laboratory Animals, Vol.31, p.1-32, 1997

7. European Convention for the Protection of Pet Animals//Strasbourg, 13.XI.1987. The document in English is available via this link on the Council of Europe website:

8. General Statement Regarding Euthanasia Methods for Dogs and Cats//Humane Society International Electronic Library, 1999. The document in English is available at the link on the HSI website: http://www.hsi.org/assets/pdfs/eng_euth_statement.pdf

9. Instructions for the use of ditilin for temporary immobilization of animals // Department of Veterinary Medicine of the Ministry of Agriculture and Food of the Russian Federation, document No. i3-5-2/i236, 05/12/1998. The document is available at the link: http://agrozoo.ru/text/vetprep_html/94.html

10. Official written response from the staff of the Federal State Institution FCTRB, prof. Yu.A. Zimakova, prof. R.D. Gareeva No. 678 dated December 17, 2006 on a request about the humaneness of using muscle relaxants for the euthanasia of domestic animals. A scan of the written response is available at the link:

Yep 01/09/2013 - 12:04

moved from about animals

shoot more humanely?
There are contradictory versions on the Internet.

Yep 01/09/2013 - 12:06

Adeline 11/28/11 18:03

Visitor
Eagle
[email protected]
Private message
Hello, I already wrote to you, but did not receive an answer, perhaps because I mixed up the thread. The situation is as follows: in our city, euthanasia by Adeline is practiced and we were told that the animal simply falls asleep without a drop of pain. We believed, in practice we saw that the animal was twitching in convulsions, although not strongly and not for long, a question arose about humanity, because we were told that anesthesia was not needed, because... from such a dose of Adeline they themselves fall asleep before they feel anything. We arrived home and read a lot of horror stories on the Internet and found the official answer from the manufacturer of this drug:

“In response to your letter, we inform you that the instructions for use of the drug Adilin-super do not specifically provide for intracardiac administration of a muscle relaxant. However, this does not mean that it cannot be used for euthanasia. Apparently, the veterinarian was guided by humane considerations, trying to facilitate and speed up the passing of your cat to another world. Current ideas about the suffering of patients who were administered muscle relaxants with insufficient anesthesia have practically no relation to cases of the use of such drugs by veterinary services for euthanasia of animals, since veterinarians, in accordance with the instructions, use very high doses of muscle relaxants. According to our data, in this In this case, a fatal outcome occurs very quickly - within 1-3 minutes after injection. Absorption of the drug occurs very quickly, and when administered intracardially or intravenously, almost instantly - “at the tip of the needle." In addition, according to encephalography, the bioelectric activity of the brain fades earlier than heart contractions, i.e. the very fact of the death of the animal occurs, with all certainty, in the absence of any sensitivity, in an unconscious state. Moreover, when the respiratory muscles are blocked, the concentration of carbon dioxide in the blood increases sharply, which itself causes a narcotic state (narcosis), i.e. general analgesic effect.
Head Laboratory, Doctor of Biology. National Science Committee, Professor Yu.A. Zimakov
Head laboratory, doctor of chemistry. National Science Committee, Professor R.D. Gareev"
http://www.zoovet.ru/forum/?tid=31&tem=571499

Stas 01/09/2013 - 12:08

Yep
shoot more humanely?

Yep 01/09/2013 - 12:17

Stas
What prevents you from giving more anesthesia?

The Supreme Court ruling also clarifies a number of other difficult cases that Russian courts have to deal with when resolving cases related to drug trafficking. However, a number of questions remained unresolved. In particular, despite the decriminalization for doctors and veterinarians of administering drugs, psychotropic or potent substances, according to medical indications, veterinarians found themselves in an unequal position with doctors. They can still be held criminally liable for the illegal acquisition and storage of such substances under Part 1 of Art. 228 of the Criminal Code of the Russian Federation. At the same time, the Resolution states: “In cases where a person uses an illegally acquired narcotic drug or psychotropic substance (for example, ketamine, ketamine hydrochloride) for the purpose of treating animals, his actions do not contain signs of a crime entailing criminal liability for the illegal sale of these drugs or substances." Thus, stated Irina Novozhilova, president of the Vita Animal Rights Center, a veterinarian can fearlessly inject ketamine into an animal, but it is not clear where this drug should come from. A special license gives legitimacy to the storage of drugs, psychotropic and potent substances by veterinarians. Meanwhile, according to Irina Novozhilova, about 75% of practicing veterinarians are not able to obtain a paid license and fulfill all the requirements associated with licensing (legal entity, the presence of a safe for storing these substances, the presence of no more than a three-day supply of them, the use of these substances exclusively within the walls of the clinic). According to her, this pushes veterinarians to perform serious medical procedures and even surgical operations using drugs that immobilize the animal, but without pain relief.

Details: http://www.regnum.ru/news/673784.html%20#ixzz2HT5xPTlY
Any use of materials is permitted only if there is a hyperlink to REGNUM IA

Stas 01/09/2013 - 12:28

Recently, less than a year ago, I euthanized a cat at the veterinary clinic on Yunnatov. Anesthesia in a horse dose in two doses, and then adeline. I did as the doctor recommended. She didn’t twitch, didn’t even move. She just fell asleep, licking my hands, and 10 minutes later they administered adeline. I paid the cashier 300 rubles more than the standard price and that’s it. Yes, I signed my name a couple of times and presented my passport. Small unlicensed clinics may have problems, but everywhere there are state veterinary stations where they will do everything for a little money.

Yep 01/09/2013 - 12:33

I called several clinics and they only injected us with Adeline.

Yep 01/09/2013 - 12:40

no, there’s another clinic where they administer propofol (and some other anesthesia) until the heart stops.
that is, no poison is injected at all.

Stas 01/09/2013 - 12:44

Yep
until the heart stops.
that is, no poison is injected at all.

Yep 01/09/2013 - 18:48

urgent need.

Forester 61 01/10/2013 - 15:03

Tomorrow I can check with the veterinarian who euthanized my Jack, I don’t remember myself, but I bought all the drugs myself at a regular pharmacy.
First, they administered a sleeping pill, and when he began to snore (he always snored in his sleep), they injected a second drug into his heart, only the tips of Jekushka’s paws shook quietly and that’s it, he went away 😞

Yep 10.01.2013 - 15:05

xYy knows him - are there any moderators here?

moved from about animals

Beautiful fox 01/10/2013 - 21:31

There is a moderator HERE, so be polite.

If the question is whether to give anesthesia before euthanasia or not, then the answer is ambiguous. When clinical death occurs, agony is observed (bending of the body, contraction of muscles), but it is believed that there is no longer consciousness and this is simply a reaction of the body. If you want to avoid it, then let the doctor pre-administer full anesthesia. The animal will leave as stress-free as possible.

Yep 01/17/2013 - 13:49

Yep 01/17/2013 - 13:51

Yep
moderators - move to medical.

Beautiful fox 01/17/2013 - 22:36

Sorry, I don't know how to move a topic to another section. Tell me how to do this or create a new topic there.

TIR 01/26/2013 - 14:55

Well it's your decision. I didn’t tell you that you need to shoot the dog without consulting your family. Perhaps this was not the best option. However, you know better.
The most humane way would probably be lethal injection of drugs. But, as you know, they have been absent from veterinary medicine for a long time. And in medicine, too, in the Russian Federation, as I found out.

Yep 26.01.2013 - 16:09

TIR
Well it's your decision. I didn’t tell you that you need to shoot the dog.

TIR 01/26/2013 - 16:21

Yep
buddy - don't worry.

© 2020 This resource is a cloud storage of useful data and is organized with donations from users of the site forum.guns.ru who are interested in the safety of their information

1. Submitted
The application was submitted to the department for supervision of the circulation of medicines for veterinary use

2. Sent to FSBI VGNKI
The registration dossier and samples were sent to the Federal State Budgetary Institution for registration tests

3. Registration testing agreement
An agreement was concluded between the applicant and the Federal State Budgetary Institution VGNKI to conduct registration tests

4. Payment made
Payment for registration tests at the Federal State Budgetary Institution VGNKI has been made

5. Registration tests
FSBI VGNKI conducts registration tests of samples

6. Preparation of an expert opinion
Based on registration tests, the Federal State Budgetary Institution VGNKI prepares an expert opinion

7.
The applicant is recommended to provide additional information/make changes to the documentation

8. Conclusion of the Federal State Budgetary Institution VGNKI
Based on the test results, the Federal State Budgetary Institution issues a conclusion on the possibility of registration of the medicinal product/feed additive

9. Documents submitted to Rosselkhoznadzor
After registration tests were carried out at the Federal State Budgetary Institution VGNKI, the documents were submitted for consideration to the “Department for Supervision of the Circulation of Medicines for Veterinary Use” of Rosselkhoznadzor

10. Harmonization of regulatory documents
The head of the veterinary supervision department of Rosselkhoznadzor coordinates regulatory and technical documentation and instructions for use

11. Documents have been sent for revision
The applicant is recommended to make changes to the regulatory and technical documentation/instructions for use

12. Documentation approval
The Deputy Head of Rosselkhoznadzor approves the regulatory and technical documentation for the medicinal product/feed additive

13. Registered / Listed
Date of state registration of the medicinal product/feed additive

14. Deregistered
The application was withdrawn from registration at the request of the applicant or by decision of Rosselkhoznadzor

15. Registration suspended
The state registration procedure has been suspended

16. Application suspended
Application suspended

17. State registration denied
According to the conclusion of the expert commission, state registration was denied

18. Registration canceled
Registration canceled

19. Confirmation of state registration
An application for confirmation of state registration has been submitted

20. Alteration
Application for amendment submitted