Aminocaproic acid percentage. Aminocaproic acid and children's health. Indications for use

Latin name: Aminocaproic acid
ATX code: B02AA01
Active substance: Aminocaproic acid
Manufacturer: Kraspharma, Russia
Dispensing from the pharmacy: Over the counter
Storage conditions: t from 2 to 25 C
Best before date: 3 years.

Aminocaproic acid is a drug from the group of hemostatics, widely used in surgery and gynecology to stop bleeding.

Indications for use

Aminocaproic acid should be used when:

• Symptomatic therapy in case of bleeding caused by thrombocytopenia, as well as defective platelet cell function
• Prevention of possible bleeding during operations on the pancreas, liver, and lungs
• Prevention and complex treatment of bleeding that occurs in internal organs and mucous membranes in erosive diseases of the gastrointestinal tract
• Treatment of menorrhagia
• Hyperfibrinolysis of various origins, including that developed with the use of thrombolytic drugs and after a blood transfusion procedure
• Conducting therapeutic therapy for acute respiratory viral infections, influenza and their prevention.

Composition and release forms

Aminocaproic acid 5% (1 ml) contains the only active component, which is e-aminocaproic acid. The solution also includes saline solution and prepared water.

Aminocaproic acid powder (1 g) includes epsilon-aminocaproic acid in an amount of 1 g.

A colorless injection solution of aminocaproic acid is bottled in glass bottles of 100 ml and 200 ml.

White fine-crystalline powder is packaged in bags (1 g), there are 10 packs inside the box.

Medicinal properties

According to the radar, the name of the drug in Latin coincides with the INN (international nonproprietary name). Epsilon-aminocaproic acid (chemical formula represented by NH2(CH2)5COOH) is classified as an artificial analogue of a substance such as lysine. It inhibits fibrinolysis, while saturation of lysine-binding receptors occurs, they promote the binding of plasmin to fibrin.

The mechanism of action is based on the inhibition of biogenic polypeptides - kinins, the effect of kallikrein, hyaluronidase, and trypsin is neutralized. A decrease in the permeability of capillary walls is recorded, antihistamine activity appears, the detoxifying function of liver cells increases, and the process of antibody formation is inhibited.

With intravenous infusion, the effect of using epsilon-aminocaproic acid is observed after 15-20 minutes. A high degree of absorption is recorded, the highest plasma level is reached after 2 hours. The half-life is 4 hours.

Approximately 40-60% of the administered dose is excreted in its original form with the participation of the renal system. In case of impaired renal function, an increase in aminocaproic acid in plasma is observed.

Aminocaproic acid: complete instructions

Price: from 30 to 60 rubles.

A 5 percent solution is used for infusion and intravenous administration. In case of acute hypofibrinogenemia, aminocaproic acid (solution for infusion) in a volume of 100 ml of solution is administered at a dose of 50-60 drops/min, the infusion duration is 30 minutes. During the first hour, it is necessary to administer 4-5 g of this drug (corresponding to 100 ml), then the dose is reduced to 1 gram (about 20 ml) per 1 hour for 8 hours until the bleeding stops completely. If re-opening of bleeding is recorded, it is recommended to administer the drug at a time interval of 4 hours.

Calculation of the dosage of the medicine for children is 100 mg per 1 kg of body weight for 1 hour, then 33 mg per 1 kg of body weight for an hour. It is worth noting that the maximum daily dosage of the drug should not exceed 18 grams per 1 m2.

Daily dosages:

• Adult patients – from 5 to 30 g
• Children in the age group up to 1 year – no more than 3 years
• Babies in the age group from 2 to 6 years – from 3 to 6 g
• Children in the age group from 7 to 10 years – no more than 6-9 g
• Children over 11 years of age are prescribed the same dosages as adults.

In case of acute blood loss, it is recommended to use the following doses of medication:

• Children under one year of age - administration of 6 g of medication is indicated
• Children from 1 year to 4 years – no more than 6-9 g should be administered
• Children from 5 years to 8 years – the dose is 9-12 g
• Children in the age group from 8 to 10 years - 18 g of medication is prescribed.

The average duration of treatment is from 3 to 14 days.

How is the powder prescribed?

Take the medicinal powder orally after first diluting it with water during meals or immediately after. It is worth noting that the daily dosage is divided into 3-6 doses, for children - into 3-5 applications.

With a slight increase in fibrinolytic activity, a daily dosage of 5 to 23 g is prescribed.

Dosages for children:

• Up to one year – 0.05 g per 1 kg of body weight
• For babies from 1 year to 7 years – no more than 3-6 g
• Children from 7 to 11 years old should take no more than 6-9 g of medication
• Teenagers (from 11 years old) – dose 10-15 g.

In the case of medical therapy for acute bleeding, the use of 5 g of drugs is prescribed, then the dose is reduced to 1 g per hour until the bleeding is completely stopped. Intended for children:

• Up to one year - no more than 6 g
• From 1 year to 5 years – about 6-9 g
• 5-9 years – no more than 9-12 g
• 10-11 years - the dose should not be higher than 18 g.

During the treatment of subarachnoid bleeding, it is recommended to drink 6-9 g of the medicine.

Traumatic hyphema: the prescribed dosage is 0.1 grams per 1 kg of body weight, taken every 4 hours for the next 5 days.

Dental pathologies: take 2-3 g up to 5 r. during the day.

• Up to 2 years - take 1-2 teaspoons 4 rubles. during the day
• Children 2-6 years old - the use of 1-2 tbsp is indicated. spoons 4 r. per day
• Children from 6 to 10 years old are prescribed 4-5 g of medicine per day
• From 10 years old - it is recommended to take 1-2 g of drugs 5 r. per day.

It is also recommended to use aminocaproic acid topically. Cotton wool is soaked in the solution and then placed for 10 minutes. into the nose, the procedure is carried out with a time interval of 3 hours. You can also instill the medicinal solution directly into the nasal passages, 4-5 drops. Intranasal use of the solution during an epidemic and for prevention - 4 rubles. throughout the day, the duration of therapy is determined individually.

Contraindications and precautions

The drug should not be used for:

• Excessive sensitivity to components
• Development of hematuria
• Coagulopathies
• Propensity to form blood clots
• Hypercoagulability
• Serious kidney pathologies
• Pregnancy, GW
• Deterioration of cerebral circulation.

The drug is used with extreme caution for pathologies of the cardiovascular system and liver, hematuria, and detection of cryptogenic bleeding (localized in the upper urinary tract).

Cross-drug interactions

You can simultaneously use hydrolysates, various anti-shock solutions, as well as glucose.

The solution should not be mixed with other drugs.

Side effects and overdose

The following side symptoms may appear:

• Severe nausea with frequent vomiting
• Rhabdomyolysis
• Swelling of the nasal mucosa
• Myoglobinuria
• Tinnitus
• Diarrhea
• Skin rashes
• Development of convulsive syndrome
• Decreased blood pressure
• Signs of orthostatic hypotension
• Kidney pathologies
• Subendocardial hemorrhage.

There is an increase in negative manifestations, and the formation of blood clots is possible. With long-term treatment, hemorrhage may develop.

Symptomatic therapy is indicated, the medication is discontinued.

Analogues

Moscow Endocrine Plant, Russia

Price from 227 to 1802 rub.

Tranexam is a hemostatic drug, has an antifibrinolytic effect, helps eliminate the inflammatory process and signs of allergy. The main active ingredient is tranexamic acid. Available in the form of tablets and solution.

Pros:

• Can be prescribed during pregnancy
• Eliminates angioedema and skin allergies
• High efficiency.

Minuses:

• May provoke the development of thromboembolism
• Should not be used simultaneously with blood products
• Dispensed by prescription.

Registration number: LP 002616-030816
Trade name: Aminocaproic acid
International nonproprietary or generic name: Aminocaproic acid
Dosage form: solution for infusion.

Composition per 1 l:
Active substance
Aminocaproic acid - 50.0 g
Excipients
Sodium chloride - 9.0 g
Water for injections up to 1.0 l
Theoretical osmolarity 689 mOsmol/l

Description.
Transparent colorless liquid.

Pharmacotherapeutic group:
Hemostatic agent - fibrinolysis inhibitor.

ATX code: B02AA01.

Pharmacological properties

Pharmacodynamics:
Aminocaproic acid is a synthetic analogue of lysine. It inhibits fibrinolysis by competitively saturating lysine-binding receptors, through which plasminogen (plasmin) binds to fibrinogen (fibrin). The drug also inhibits biogenic polypeptides - kinins (inhibits the activating effect of streptokinase, urokinase, tissue kinases on fibrinolysis), neutralizes the effects of kallikrein, trypsin and hyaluronidase, reduces capillary permeability. Aminocaproic acid has an antiallergic effect, enhances the detoxifying function of the liver, and inhibits antibody formation.
Pharmacokinetics:
When administered intravenously, the effect appears within 15-20 minutes. Absorption is high, Cmax - 2 hours, half-life (T1/2) - 4 hours. Excreted by the kidneys - 40-60% unchanged. If the excretory function of the kidneys is impaired, the excretion of aminocaproic acid is delayed, as a result of which its concentration in the blood increases sharply.

Indications for use

Bleeding (hyperfibrinolysis, hypo- and afibrinogenemia), bleeding during surgical interventions and pathological conditions accompanied by an increase in fibrinolytic activity of the blood (during neurosurgical, intracavitary, thoracic, gynecological and urological operations, including on the prostate gland, lungs, pancreas; tonsillectomies, after dental interventions, during operations using a heart-lung machine). Diseases of internal organs with hemorrhagic syndrome. Premature placental abruption, prolonged retention of a dead fetus in the uterine cavity, complicated abortion. Prevention of secondary hypofibrinogenemia during massive transfusions of preserved blood.

Contraindications

Hypersensitivity to the drug, tendency to thrombosis and thromboembolic diseases, hypercoagulation (thrombosis, thromboembolism), coagulopathy due to diffuse intravascular coagulation, cerebrovascular accidents, pregnancy.

Carefully:

Arterial hypotension, bleeding from the upper urinary tract (due to the risk of intrarenal obstruction caused by thrombosis of the glomerular capillaries or the formation of clots in the lumen of the pelvis and ureters; use in this case is possible only if the expected benefit outweighs the potential risk), subarachnoid hemorrhage, liver failure , renal dysfunction.

Use during pregnancy and breastfeeding

The use of the drug during pregnancy is contraindicated. Data on the use of aminocaproic acid in pregnant women are limited. Animal studies have shown impaired fertility and a teratogenic effect with the use of aminocaproic acid.
There is no data on the excretion of aminocaproic acid into breast milk, and therefore breastfeeding should be discontinued during the treatment period.

Directions for use and doses

Intravenously, drip. If it is necessary to achieve a quick effect (acute hypofibrinogenemia), up to 100 ml of a 5% solution is administered at a rate of 50-60 drops per minute for 15-30 minutes. During the first hour, a dose of 4-5 g (80-100 ml) is administered, and then, if necessary, 1 g (20 ml) every hour for about 8 hours or until bleeding stops completely. In case of ongoing or repeated bleeding, infusions of 5% aminocaproic acid solution are repeated every 4 hours.
For children, at the rate of 100 mg/kg - at 1 hour, then 33 mg/kg/hour; the maximum daily dose is 18 g/m2 of body surface. The daily dose for adults is 5-30 g. The daily dose for children under 1 year is 3 g; 2-6 years - 3-6 g; 7-10 years - 6-9 g, from 10 years - as for adults. For acute blood loss: children under 1 year - 6 g, 2-4 years - 6-9 g, 5-8 years - 9-12 g, 9-10 years - 18 g. Duration of treatment - 3-14 days.

Side effect

The most commonly reported effects were dizziness, decreased blood pressure (including orthostatic hypotension) and headache.
Cases of myopathy and rhabdomyolysis were generally reversible after discontinuation of treatment, but creatine phosphokinase (CPK) should be monitored in patients receiving long-term treatment with aminocaproic acid and treatment should be discontinued if CPK increases.

Organ system Common (≥1/100 Blood and lymphatic system agranulocytosis, coagulation disorders leukopenia, thrombocytopenia
Immune system allergic and anaphylactic reactions maculopapular rashes
Nervous system dizziness confusion, convulsions, delirium, hallucinations, increased intracranial pressure, cerebrovascular accident, fainting
Visual organs: decreased visual acuity, lacrimation
Hearing organs tinnitus
Cardiovascular system decreased blood pressure bradycardia ischemia of peripheral tissues thrombosis, subendocardial hemorrhage
Respiratory system and chest organs nasal congestion shortness of breath pulmonary embolism inflammation of the upper respiratory tract
Gastrointestinal tract abdominal pain, diarrhea, nausea, vomiting
Skin and subcutaneous tissue itching, rash
Musculoskeletal and connective tissue muscle weakness, myalgia increased CPK activity, myositis acute myopathy, rhabdomyolysis, myoglobinuria
Kidneys and urinary tract acute renal failure, increased blood urea nitrogen, renal colic, impaired renal function
Genitals Dry ejaculation
General disorders and disorders at the injection site: headache, general weakness; pain and necrosis at the injection site swelling

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: decreased blood pressure, seizures, acute renal failure.
Treatment: discontinuation of drug administration, symptomatic therapy. Aminocaproic acid is excreted during hemodialysis and peritoneal dialysis.

Interaction with other drugs

Can be combined with the introduction of hydrolysates, glucose solution (dextrose), anti-shock solutions. In case of acute fibrinolysis, it is additionally necessary to administer fibrinogen in an average daily dose of 2-4 g (maximum dose 8 g).
Do not mix aminocaproic acid solution with solutions containing levulose, penicillin, or blood products.
Reduced effectiveness when taking direct and indirect anticoagulants and antiplatelet agents simultaneously.
Concomitant use of aminocaproic acid with prothrombin complex concentrates, coagulation factor IX preparations and estrogens may increase the risk of thrombosis.
Aminocaproic acid inhibits the action of plasminogen activators and, to a lesser extent, the activity of plasmin.

special instructions

When prescribing the drug, it is necessary to establish the source of bleeding and monitor the fibrinolytic activity of the blood and the concentration of fibrinogen in the blood. Monitoring of the coagulogram is necessary, especially in case of coronary heart disease, after myocardial infarction, and in pathological processes in the liver.
The use of aminocaproic acid in women for the prevention of increased bleeding during childbirth is not recommended due to the increased risk of thrombosis in the postpartum period.
With rapid administration, arterial hypotension, bradycardia and cardiac arrhythmia may develop.
In rare cases, after long-term use, damage to skeletal muscles with necrosis of muscle fibers has been described. Clinical manifestations can range from mild myalgia and muscle weakness to severe proximal myopathy with rhabdomyolysis, myoglobinuria, and acute renal failure. It is necessary to monitor CPK in patients undergoing long-term treatment. The use of aminocaproic acid should be discontinued if an increase in CPK is observed. When myopathy occurs, it is necessary to consider the possibility of myocardial damage.
The use of aminocaproic acid may alter the results of platelet function tests.
Effect on the ability to drive a car and perform work associated with increased danger - no data available due to the exclusive use of the drug in a hospital setting.

Release form
Solution for infusion 5%, 100, 250, 500 or 1000 ml in polyvinyl chloride polymer containers for single-use infusion solutions KPIR with two sterile ports. Each container is placed in a bag made of polyethylene or polyethylene-polyamide films (double sterile vacuum packaging).
Containers in bags are placed in a corrugated cardboard box with gaskets: 50, 75 pieces (100 ml), 24, 36 pieces (250 ml), 12, 18 pieces (500 ml), 6, 9 pieces (1000 ml ). Instructions for the medical use of the drug and instructions for the use of infusion solutions in polymer containers are placed in a box with bags at the rate of 1 piece per 6 containers (for hospitals).

Best before date:
3 years.
The medicinal product should not be used after the expiration date indicated on the packaging.

Storage conditions:
In a place protected from light at a temperature of 0 to 25 ° C.
Keep out of the reach of children.

Aminocaproic acid instructions

The instructions provide the patient with all the information regarding the drug Aminocaproic acid and its correct use. In addition, the accompanying sheet provides full information about side effects and contraindications to taking the drug.

Form, composition, packaging

This drug consists of aminocaproic acid in its pure form, which can only be diluted with one of the physiological solutions. The dilution solution does not affect either the effect of the drug or its physical properties. Typically, per 100 milliliters of aminocaproic acid solution there are at least five grams of the drug.

The packaging for the drug is a box made of a thick sheet of cardboard, into which a bottle of solution is placed, hermetically sealed with a volume of 100 or 200 milliliters.

Storage period and conditions

The shelf life of the drug is 24 months. It should be stored in dry rooms, protected from sunlight, where the ambient temperature is no more than 25 degrees and no less than zero.

Pharmacology

As a hemostatic agent, caproic acid can prevent the conversion of profibrinolysins into fibrinolysins. She succeeds in this thanks to her ability to inhibit the substance that activates this process. In addition, aminocaproic acid can inhibit the action of those substances that help thin the blood.

The drug also has an effect on reducing the permeability of capillary vessels and has pronounced properties against allergies and toxicity.

Pharmacokinetics

Within a quarter of an hour, the drug administered intravenously begins to have an effect, thereby helping to reduce bleeding.

The process of excretion of aminocaproic acid is carried out by the kidneys. Half of the administered dose leaves the body after 4 hours. If there are problems with the urinary functionality of the kidneys, the patient should adjust the dose of the drug downward.

Aminocaproic acid indications for use

Indications for the use of aminocaproic acid are a number of situations in which the body's hemostatics are not able to cope with their task in full, although in practice the solution is used for any type of bleeding that occurs.

• performing surgery on the lungs, thyroid gland, brain, pancreas, uterus and prostate gland;
• after surgery on blood vessels or in the heart area;
• when using machines for hemodialysis or artificial blood circulation;
• with premature placental abruption;
• when performing a complicated abortion;
• with the development of uterine bleeding;
• with nosebleeds;
• in the presence of a disease that is accompanied by bleeding combined with pain (bleeding of the gastrointestinal tract or bladder);
• in the case of simultaneous blood transfusion in large quantities in order to prevent the development of secondary hypofibrinogenemia.

Contraindications

Contraindications to the use of the drug are those patient conditions that have symptoms opposite to those ailments that have recommendations for the use of acid, namely, accompanied by the development of bleeding.

The drug should not be prescribed

• if there is a tendency to thromboembolic diseases and thrombosis;
• when the patient suffers from coagulopathy with increased intravascular blood clotting;
• Impaired kidney function;
• if there are symptoms of cerebral circulation;
• during pregnancy;
• in the presence of disseminated intravascular coagulation syndrome;
• when bleeding from the respiratory tract is detected, the cause of which is not clear.

Acute bleeding

As an intravenous infusion. A 5% solution of the drug is used. An initial dose of 100 milliliters is administered from 15 minutes to half an hour, 60 drops per minute.

If necessary, you can add 20 milliliters of solution. Continuous infusion can last up to eight hours. If it was not possible to achieve a complete stop of bleeding after four hours, the drug can be repeated.

Gastrointestinal bleeding

The drug is taken orally. It is advisable to take the drug cold, which will promote spasms of the mucosal vessels. It is not necessary to dose the drug. You can drink it instead of regular drinking water.

Nosebleed

Instill the solution a few drops as needed, or use tampons soaked in the drug to place in the nasal passages.

Aminocaproic acid during pregnancy

During pregnancy, Aminocaproic acid is absolutely contraindicated, since its use can lead to premature placental abruption. Indeed, during pregnancy, the level of fibrinogen in a woman’s body increases significantly. In this way, nature has provided for the prevention of miscarriages and possible hemorrhage in the event of minor injury to the pregnant woman’s abdomen. If we add aminocaproic acid to this, thrombosis of the placental veins will be quite possible.

The drug has no contraindications for nursing mothers.

Aminocaproic acid for children

Aminocaproic acid is prescribed to children with caution. For babies under one year old only when absolutely necessary.

Side effects

Side effects are sometimes impossible to prevent, since the drug is in most cases used for emergency care. Therefore, after using the drug, the patient should be warned about the possible occurrence or development of:

• headaches and dizziness;
• hemorrhages under the mucous membrane of the heart;
• tinnitus;
• acute renal failure;
• dyspeptic manifestations in the form of diarrhea, vomiting or nausea;
• rhabdomyolysis;
• nasal congestion;
• myoglobinuria;
• seizures;
• development of collapse in the form of a drop in blood pressure.

Overdose

Symptoms of drug overdose will be increased adverse reactions, and the level of fibrinolysis will be sharply suppressed.

To eliminate this condition, urgent administration of plasminogen activators is necessary.

Drug interactions

Being a drug primarily used for emergency care, aminocaproic acid is often used simultaneously with various medications, the interaction of which must be taken into account in order to achieve the maximum therapeutic effect and not cause harm.

• anticoagulants: flenox, heparin, clexane, fraxiparin reduce the effect of acid. The drugs aspirin and cropidogrel - direct antagonists of caproic acid - also act.
• combination with anti-shock drugs in the form of glucose, hydrolyzate and others does not lead to a change in the effectiveness of the acid;
• the administration of aminocaproic acid must necessarily be accompanied by fibrinogen infusions, since when using an acid solution, its level in the blood decreases significantly;
• food enriched with fats is contraindicated in treatment due to the increase in lipids in the blood with its consumption, and this in turn leads to the binding of acid molecules, which can reduce its overall effect.

Additional instructions

When prescribing and using aminocaproic acid, it is necessary to monitor the fibrinolytic activity of the blood, as well as conduct a coagulogram, especially for those patients who suffer from ischemia, liver pathology, or have recently suffered a heart attack.

Aminocaproic acid analogs

This is an original medicinal solution that has no analogues.

Aminocaproic acid price

The cost of the drug is more than acceptable. It ranges from 30 to 70 rubles per bottle.

Aminocaproic acid reviews

Reviews about the drug are almost all positive, and people have used the drug in a variety of situations and noted only good results. There are quite a few reviews, however, they are all of varying degrees of age. Let us cite, perhaps, those that arrived quite recently.

Larisa: My husband recently had a tooth and tartar removed, which consequently required subsequent gum treatment. The doctor advised me to purchase aminocaproic acid in combination with other necessary medications. This solution was to be used to treat the mouth, which consisted of the following: after brushing the teeth, he kept the solution in the mouth for several minutes and then changed it. There was no need to rinse, no matter what bothered the painful gums. The treatment lasted about five days, although already on the second he boasted about how healthy his gums looked. In a word, the acid solution left a very good impression on itself, and when I found out that it can be used quite widely, I went out and bought a bottle in reserve.

Valeria: Aminocaproic acid helps my daughter and I fight a runny nose. The pediatrician advised treating the baby with this solution, putting a drop in her nose several times a day. When I saw a positive result, without hesitation, I took it for myself. The treatment result is excellent, the solution is gentle and costs a penny. Store the opened bottle on the refrigerator door.

Zinaida: The whole family treats colds with aminocaproic acid, which we buy in solution. It works well for a runny nose, both in the form of inhalation and simple instillation. The acid is equally effective for both adults and children. It is gentle, does not burn in the nose and makes breathing easier. The cost also fully satisfies our needs, since we have a large family with many children, so we purchase the drug in large quantities at once.

Natalia: When the child reached kindergarten, health problems began. Frequent colds and constant snot forced me to look for a reliable remedy for treatment. I was advised to buy a solution of aminocaproic acid, which was described as a universal drug that would get rid of colds in no time. During the conversation, I was embarrassed to ask about the cost of the miracle solution and was pleasantly surprised at its availability at the pharmacy. In fact, the acid turned out to be really very effective in eliminating a runny nose and alleviating the child’s condition literally from the first use. Now we will not part with her. We drip into the nose when there is congestion, we drip into the mouth as an antiviral agent and at high temperatures to avoid serious consequences. Recently we tried inhalation and the effect was amazing. The medicine is truly universal because we now use it for treatment with the whole family and are very pleased with the result.

Galina: Our daughter suffers from frequent nosebleeds due to intracranial pressure and weak blood vessels. The child is so used to it that he is no longer afraid of blood. Doctors shrug their shoulders. Lately the bleeding has not stopped for a long time and it has become clear that we should look for means to help. One of my friends suggested that we try this solution. And it really helped. Having stopped the bleeding, we drop a few more drops into the nose and the child does not worry for a long time. For some reason, the doctors didn’t tell us about this ambulance option.

Similar instructions:

Hemostatic sponge

Cryoprecipitate: instructions, indications, composition

Aminocaproic acid solution is classified as a hemostatic and antihemorrhagic agent.

On this page you will find all the information about Aminocaproic acid: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews from people who have already used Aminocaproic acid. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Hemostatic drug. Fibrinolysis inhibitor – inhibitor of the transition of plasminogen to plasmin.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Aminocaproic acid cost? The average price in pharmacies is 190 rubles.

Release form and composition

Aminocaproic acid is a hemostatic drug that inhibits the conversion of profibrinolysin to fibrinolysin.

Issued:

• Powder for the preparation of solution for intravenous use;
• Granules (Aminocaproic acid for children);
• 5% solution of the product in isotonic sodium chloride solution.

Aminocaproic acid can be used:

• For intravenous injections. This method is most in demand for acute bleeding, as well as during surgical treatment.
• For oral administration. This use of the drug is indicated not only for bleeding, but also for rotavirus.
• For instillation into the nose. Both a ready-made solution and powdered or granulated Aminocaproic acid mixed with unsweetened water are used (a 5% solution is also prepared from this form of the medicine).
• For inhalation. The procedures are carried out with a nebulizer for adenoids, cough, as well as for prolonged runny nose or sinusitis.
• For rinsing the nose. This manipulation is sometimes prescribed to remove yellow or green thick nasal discharge. In this case, washing must be carried out by a doctor, since an incorrect procedure can cause increased swelling and irritation of the mucous membrane.

Pharmacological effect

Aminocaproic acid is an antihemorrhagic and hemostatic drug that has a specific hemostatic effect in bleeding related to increased fibrinolysis (the process of dissolving blood clots).

This drug helps reduce capillary permeability, as well as inhibit fibrinolysis in general. Aminocaproic acid increases the antitoxic abilities of the liver and exhibits moderate antishock and antiallergic activity. The drug can improve some indicators of specific and nonspecific protection in acute respiratory viral infections.

After use, the maximum concentration of Aminocaproic acid in the blood is observed after 2-3 hours. There is virtually no binding to plasma proteins. The main part of the drug is excreted unchanged by the kidneys, and 10-15% is biotransformed in the liver. The accumulation of aminocaproic acid occurs only if there are disturbances in urinary function.

Indications for use

According to the instructions, Aminocaproic acid is prescribed to prevent and stop bleeding that is associated with increased fibrinolytic activity, or the state of hypofibrinogenemia and afibrinogenemia.

Indications for use of the drug are:

• Complicated abortion and uterine bleeding;
• Premature placental abruption;
• Operations in the area of ​​ENT organs and nosebleeds;
• Surgical operations on organs that are rich in fibrinolysis activators (brain, lungs, adrenal glands, uterus, pancreas, thyroid and prostate);
• Extracorporeal circulation;
• Postoperative recovery period (for surgical operations on blood vessels and the heart);
• Burn disease;
• Diseases of internal organs complicated by hemorrhagic syndrome (bleeding from the bladder, gastrointestinal bleeding).

Doctors of the old school often prescribe it for ENT pathologies. In such cases, it is used for the following purposes:

• eliminating swelling of the mucous membrane and a feeling of nasal congestion;
• reducing the amount of mucus produced;
• reducing the severity of the inflammatory process, in particular with rhinitis of allergic origin;
• stopping nosebleeds.

Since ACC is a compound close to the human body, in many cases it is even prescribed to prevent the development of complications in mild forms of rhinitis. But such a preventive measure is indicated only if the child has a tendency to nosebleeds or diseases accompanied by increased capillary fragility.

Thus, the medicine is indicated for:

• any etiology, including allergic;
• all types;
• nosebleeds;
• flu and acute respiratory infections.

Aminocaproic acid is also often instilled into a child’s nose during the so-called cold season.

Contraindications

The drug is contraindicated in:

1. Individual intolerance;
2. Tendency to thrombosis and thromboembolic diseases;
3. Kidney diseases with impaired kidney function;
4. Coagulopathies based on diffuse intravascular coagulation;
5. DIC syndrome;
6. Pregnancy and lactation;
7. Cerebral circulation disorders;
8. Bleeding from the upper respiratory tract of unknown origin.

Use during pregnancy and lactation

The drug is not prescribed to pregnant and lactating women. This remedy is not advisable in cases where there is a possibility of increased blood loss during childbirth, because thromboembolic complications may develop in the postpartum period.

Instructions for use

The instructions for use indicate that Aminocaproic acid is used IV, drip.

If it is necessary to achieve a quick effect (acute hypofibrinogenemia), up to 100 ml of a 50 mg/ml solution is administered at a rate of 50-60 drops per minute for 15-30 minutes. During the first hour, a dose of 4-5 g (80-100 ml) is administered, and then, if necessary, 1 g (20 ml) every hour for about 8 hours or until bleeding stops completely.

In case of ongoing or repeated bleeding, infusions of 50 mg/ml aminocaproic acid solution are repeated every 4 hours.

For children, at the rate of 100 mg/kg – at 1 hour, then 33 mg/kg/hour; maximum daily dose -18 g/sq.m. The daily dose for adults is 5-30 g. The daily dose for children under 1 year is 3 g; 2-6 years – 3-6 g; 7-10 years - 6-9 g, from 10 years - as for adults. For acute blood loss: children under 1 year – 6 g, 2-4 years – 6-9 g, 5-8 years – 9-12 g, 9-10 years – 18 g. Duration of treatment – ​​3-14 days.

Aminocaproic acid in the nose: instructions

It is also recommended to use the drug Aminocaproic acid in the nose (for a child or an adult), locally. Place a cotton swab into the nasal passage for 10 minutes every three hours, pre-moistened with a solution of 5% Aminocaproic acid, or, observing the specified frequency, instill 4-5 drops of the solution into the nasal passages. The drug can be used for inhalation by children and adults. In such cases, a nebulizer can be used for inhalation for the child.

• In severe hypertoxic types of influenza or ARVI, the dosage of the drug is allowed to be increased to the maximum recommended at a given age with a moderate increase in fibrinolytic activity.
• Aminocaproic acid, if necessary, can be used in combination with other antiviral drugs, interferon-containing agents and interferon inducers.
• Intranasal instillation of Aminocaproic acid up to four times a day is advisable to carry out during the epidemic period for prevention.

The duration of therapy depends on the severity of the disease and is determined individually by the doctor.

Side effects

Aminocaproic acid is usually well tolerated, but the following adverse reactions may occur.

1. From the nervous system: headache, dizziness, tinnitus, convulsions.
2. From the cardiovascular system: orthostatic hypotension, subendocardial hemorrhage, bradycardia, arrhythmia.
3. From the digestive tract: nausea, vomiting, diarrhea.
4. From the blood coagulation system: blood clotting disorders.
5. Others: possible hypersensitivity reactions (including catarrhal phenomena of the upper respiratory tract), skin rash, myoglobinuria, rhabdomyolysis, acute renal failure.

Side effects are rare and dose-dependent; they usually disappear when the dose is reduced.

When applied topically, ACC is quite safe and rarely causes the development of undesirable consequences and side effects.

Overdose

Symptoms of an overdose of Aminocaproic acid: increased side effects, formation of blood clots, embolism. With long-term use (more than 6 days) of high doses (for adults - more than 24 g per day) - hemorrhages.

Treatment: drug withdrawal, symptomatic therapy.

special instructions

Before you start using the drug, you must carefully study the instructions for its use. It is worth paying attention to the features of its use:

1. Long-term use of Aminocaproic acid or its intravenous administration in the form of a solution should be accompanied by laboratory monitoring of the functional state of the blood coagulation system.
2. During the period of use of the drug, it is necessary to avoid eating fatty foods, which can provoke thrombus formation in the vessels with subsequent thromboembolism.
3. Aminocaproic acid should not be taken together with oral contraceptives, as this may increase blood clotting.
4. During the treatment period, you cannot perform work that requires increased concentration of attention and speed of psychomotor reactions.

Drug interactions

Can be combined with the introduction of hydrolysates, glucose solutions (dextrose solutions), anti-shock solutions. In acute fibrinolysis, the administration of aminocaproic acid with a fibrinogen content of 2-4 g (maximum - 8 g) must be supplemented with a subsequent infusion.

No medications should be added to the aminocaproic acid solution.

Antiplatelet reduction with simultaneous use of direct and indirect anticoagulants.

Colds and snot are frequent companions for children. Despite the fact that the modern pharmacological industry produces a lot of drugs for the treatment of infectious and inflammatory diseases, in practice they turn out to be ineffective. Experienced pediatricians advise remembering a proven remedy - aminocaproic acid. It is dropped into the child’s nose or used for inhalation.

Action and efficiency

Aminocaproic acid is a drug used in surgery to stop bleeding. The drug can slow down the process of fibrinolysis (destruction of blood clots). In addition, it reduces the permeability of capillary vessels, exhibits antiallergic and antishock effects, and also increases the antitoxic functions of the liver.

The drug has antiviral activity, improves the body's specific defense in acute respiratory infections (acute respiratory diseases).

Its maximum content in the blood is reached within three hours and is excreted unchanged through the urinary system.

The main active ingredient is aminocaproic acid. An auxiliary component for the liquid form is an isotonic sodium chloride solution.

The product is released in the form:

• powder for oral use in sachets of 1 g;
• tablets with a dosage of 0.5 g (pack of 20 pcs.);
• 5% solution for infusion in glass bottles of 100 ml.

Unfortunately, the domestic market offers the drug only in the form of an injection solution. The product in other forms of release can be purchased in foreign countries.

Indications for use

According to the instructions, the indications for use of the drug are:

• blood clotting disorders;
• various types of bleeding and their prevention;
• postoperative period;
• prevention and treatment of influenza;
• liver pathologies (heartburn, vomiting).

Since the drug reduces capillary permeability and also has an antiallergic effect, it can be prescribed to children for:

• reducing swelling during a runny nose;
• reducing mucous and purulent nasal discharge;
• strengthening the walls of blood vessels;
• getting rid of unpleasant symptoms of allergic rhinitis (itching, burning, prolonged sneezing);
• removing toxins from the body;
• increasing immunity.

Interesting fact! Aminocaproic acid is the main component of the nasal drug Salin. At the same time, the cost of a foreign analogue is several times more expensive than a domestic product.

For newborns, drops are placed in the nose 3 times a day.

Since the solution is sterile, it is not recommended to tear off the rubber cap. It is pierced with a syringe needle and the required amount of liquid is drawn. The medicine is stored at temperatures up to 25 0 C for no more than two years.

For long-term diseases of the upper respiratory tract, sinusitis, adenoids, and severe cough, doctors recommend inhalation. To do this, the required amount of aminocaproic acid is diluted with saline and placed in a nebulizer.

The procedure is carried out 1–2 times/day for 5–10 minutes. The liquid is preheated to 30 0 C.

Inhalations for babies under one year of age are carried out only under adult supervision.

Rinsing the nasal passages

For newborns, lubricate the nose with cotton pads soaked in a solution of aminocaproic acid.

The course of therapy depends on the severity of the disease and is adjusted by the doctor. If necessary, repeated treatment is prescribed.

How to rinse your nose correctly - video

Rules for using the medicine - gallery

Instillation is a popular and simple method of treatment with aminocaproic acid. It is recommended to rinse the nasal sinuses for grade I adenoids, sinusitis, severe nasal congestion, and thick mucous discharge. For inhalation with aminocaproic acid, it is better to use a nebulizer

Analogues

In the pharmaceutical network there are enough similar products for the treatment of colds, runny nose, and stopping bleeding.

Substitutes - table