Cortexin instructions for use bottle 5 10 mg. Cortexin indications for use, instructions for children, reviews. How to dilute a powdery substance

A peptide bioregulator that has cerebroprotective, nootropic and anticonvulsant effects, reduces the toxic effects of neurotropic substances, improves learning and memory processes, stimulates reparative processes in the brain, accelerates the recovery of brain function after stressors. Cortexin is obtained by extraction from the cerebral cortex of cattle and pigs. In medical practice, it is used in the form of a clear, colorless solution, which is prepared from white lyophilized powder.

Cortexin instructions for use

International name - Livestock cerebral cortex polypeptides.
Tradename - ( Cortexin).

Release forms

Lyophilisate for the preparation of solution (10 mg) for intramuscular administration. In 1 bottle: cortexin 10 mg, glycine 12 mg. In a cardboard pack there are 10 bottles of 10 mg each;

Pharmacological group

Nootropic drug.

pharmachologic effect

• brain hydrolyzate
• antioxidant
• nootropic
• stimulating protein synthesis in the central nervous system

Cortexin indications for use

Cortexin is used in adults for traumatic brain injury, cerebrovascular accidents, viral and bacterial neuroinfections, asthenic conditions, encephalopathies of various origins, acute and chronic encephalitis and encephalomyelitis, epilepsy, memory impairment, thinking, reduced learning ability, suprasegmental autonomic disorders.

• Meningitis.
• Anoxic brain damage.
• Intracranial injury.
• Disorders of the autonomic (autonomic) nervous system.
• Epilepsy and epileptic syndromes.
• Malaise and fatigue
• Somatoform disorders
• Vascular dementia
• Brain compression
• Encephalitis, myelitis and encephalomyelitis
• Benign intracranial hypertension
• Dementia
• Cerebrovascular diseases

Pharmacodynamics

Cortexin contains a complex of low molecular weight, water-soluble polypeptide fractions that penetrate through the BBB directly to nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.

Nootropic - improves higher brain functions, learning and memory processes, concentration, resistance to various stress influences.

Neuroprotective - protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

Antioxidant - inhibits lipid peroxidation in neurons, increases the survival of neurons under conditions of oxidative stress and hypoxia.

Tissue-specific - activates the metabolism of neurons in the central nervous system and peripheral nervous system, reparative processes, helps improve the functions of the cerebral cortex and the general tone of the nervous system.

The mechanism of action of Cortexin is due to the activation of neuronal peptides and neurotrophic factors of the brain; optimization of the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABAergic effects; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectrical activity; preventing the formation of free radicals (products of lipid peroxidation).

Dosage regimen

Only intramuscular use of Cortexin is practiced.

For adults Cortexin injections are given once a day for 5-10 days.

Cortexin for children weighing more than 20 kg prescribed in the same way as for adults.

Children weighing up to 20 kg (including newborns) give injections of 5 mg once a day. In pediatrics, a course of treatment is prescribed lasting 5-10 days. If necessary, therapy is repeated after 1-6 months.

How to dilute Cortexin

To prepare an injection solution, the drug powder from 1 bottle is diluted in 1-2 ml of 0.9% sodium chloride solution, special water for injection, or 0.5% procaine solution.

Contraindications

Individual intolerance to the drug, pregnancy.

Pregnancy and lactation

The drug is contraindicated for use during pregnancy due to the lack of clinical trial data. If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped (due to the lack of clinical trial data).

Storage conditions

In a dry place, protected from light, at a temperature of 2 to 20? C. List B.

Release from pharmacies

By doctor's prescription.

Best before date

Cortexin's analogs

Analogues obtained by extraction from the cerebral cortex of cattle and pigs: Cerebrolysin, Cerebrolysat.

Other nootropics and angioprotectors: Aminalon (Gamma-aminobutyric acid), Vasobral,
Gliatilin (Cerepro), Glycine, Cavinton (Vinpocetine), Mexidol, Pantogam (Hopantenic acid), Picamilon, Piracetam (Nootropil, Lucetam), Ginkgo Biloba preparations, Sermion (Nicergoline), Trental (Pentoxifylline), Phezam, Omaron (Piracetam + Cinnarizine ), Phenotropil, Ceraxon (Citicoline), Cytoflavin, Encephabol (Pyritinol).

Cortexin - instructions for use (how to dilute, how to give injections), analogues, reviews

Thank you

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

The drug is used in the complex treatment of traumatic brain injuries, cerebral circulatory disorders, neuroinfections, encephalopathies, encephalitis, encephalomyelitis, epilepsy, vegetative-vascular dystonia, cerebral palsy, delayed psychomotor and speech development in children, as well as memory, thinking and ability disorders. training.

Composition and release forms

The lyophilisate is a special dried extract of protein fractions obtained from the cerebral cortex of cattle and pigs. It is this peptide extract that is the active component of the Cortexin drug. Each glass bottle contains 10 mg of extract of protein fractions of the cerebral cortex of cattle and pigs.

In addition, on the pharmaceutical market of the CIS countries there was children's Cortexin, the bottles of which contained only 5 mg of lyophilisate of protein fractions of the cerebral cortex of cows and pigs. Apart from the dosage, Cortexin for children and adults are no different.

The lyophilisate contains only the amino acid glycine as an auxiliary component. Externally, the lyophilisate is a powder or a homogeneous porous mass of white or white-yellowish color.

Therapeutic effect

Cortexin has the following therapeutic effects:

• Neuroprotective (cerebroprotective);
• Nootropic;
• Anticonvulsant;
• Antioxidant.

Nootropic effect Cortexina is to improve the cognitive function of the brain. That is, it becomes easier for a person to study, work, learn new things, etc., since memory, concentration and resistance to stress improve.

Anticonvulsant action lies in the ability to suppress the activity of the pathological focus in the brain and, thereby, prevent the development of seizures.

Antioxidant action is to slow down the process of lipid peroxidation and, thereby, prevent damage to cells of various brain structures by free radicals. In addition, Cortexin increases the survival of brain cells under hypoxic conditions.

In addition to the above effects, Cortexin has tissue-specific action, which consists in activating metabolic and reparation processes in the structures of the brain, thereby improving the functional state and general tone of the central nervous system.

The mechanism of action of Cortexin is ensured by the activation of neurons and neurotrophic factors of the brain, due to which the transfer of information between brain structures occurs much faster and more efficiently. In addition, Cortexin optimizes the balance of inhibitory and excitatory amino acids, dopamine and serotonin in the brain, which reduces seizure activity and improves bioelectric potential.

Indications for use

• Cerebrovascular accidents;
• Traumatic brain injuries and their consequences;
• Encephalopathy of any origin;
• Cognitive disorders (memory, attention, thinking disorders);
• Acute or chronic encephalitis or encephalomyelitis;
• Vegetovascular dystonia;
• Reduced ability to learn and assimilate new things;
• Delayed psychomotor development of children;
• Delayed speech development in children;
• Critical conditions of newborns with perinatal damage to the central nervous system.

Cortexin - instructions for use

How to dilute Cortexin

The bottle with lyophilisate (for both children and adults) contains one dose of Cortexin, which is dissolved immediately before the injection, and the resulting ready-made solution is administered intramuscularly. The contents of the bottle can be diluted with the following solvents:

• 0.5% solution of novocaine;
• Water for injection is sterile;
• Saline solution, sterile for injection.

To dilute the lyophilisate, it is recommended to purchase solutions of novocaine, physiological or water for injection, bottled in small containers, for example, vials or ampoules. It is optimal to purchase ampoules or bottles of 2 ml or 5 ml in order to use the entire available solution at one time. This requirement is due to the fact that solutions for diluting Cortexin lyophilisate must be sterile, and it is impossible to maintain the sterility of an ampoule or bottle of relatively large volume once opened at home. Therefore, it is better to use a sterile solution for each dilution, previously stored in a hermetically sealed container.

To dilute an adult or children's lyophilisate, 1 - 2 ml of any specified solution is required. Dilution is carried out as follows:
1. Take a sterile syringe of the required volume and place the needle on the needle holder.
2. Open the ampoule with the solvent.
3. Place the needle into the bottle or ampoule and draw out the required amount of solution (1 - 2 ml).
4. Remove the aluminum foil from the stopper on the bottle with Cortexin lyophilisate (if any).
5. Pierce the rubber stopper on the bottle with the lyophilisate with the needle of the syringe containing the solvent.
6. Lower the needle approximately to the middle of the bottle with lyophilisate.
7. Slowly pressing the syringe plunger release the solvent into the lyophilisate. To prevent the lyophilisate from foaming, it is recommended to point the needle from the syringe at the wall of the bottle, since in this case the liquid will flow evenly down the glass and fall on the powder without blowing it up.
8. When the entire volume of the solvent has been released into the lyophilisate, it is necessary, without removing the syringe needle, to gently rock the bottle from side to side to ensure complete dissolution of the powder. When the vial contains a homogeneous solution without flakes, this means that the lyophilisate has completely dissolved and can be used for injection.

After complete dissolution of the lyophilisate, it is drawn into a syringe. You can draw up the lyophilisate with the same needle that was used to dissolve the drug, provided that it was not removed from the stopper while the solution was being mixed. If the needle was removed from the stopper of the bottle with the lyophilisate, then to draw the finished solution into the syringe, you should take another sterile needle, since it is this one that will be used for the subsequent injection.

Cortexin lyophilisate should be diluted immediately before making the injection and used immediately after obtaining the solution, since the latter cannot be stored. If for some reason the Cortexin solution was not administered immediately after preparation and stood for more than 20 minutes, then it should be thrown away and the re-diluted lyophilisate from another bottle should be used.

The finished solution of Cortexin cannot be mixed with other medications; it must be administered separately.

Dosage of the drug

During a stroke and in the rehabilitation period after it It is recommended to administer 10 mg of Cortexin intramuscularly (1 bottle) twice a day for 10 days. Then they take a break for 10 days, and again administer one bottle of Cortexin 2 times a day for another 10 days. Two such courses of treatment with a 10-day break between them are sufficient and complete for treating ischemic stroke and improving rehabilitation after its completion. It is preferable to give injections in the morning and during the day, since administration of the drug in the evening can provoke excessive agitation and difficulty falling asleep. If necessary, the course of Cortexin can be repeated, maintaining an interval of 3 to 6 months between the two subsequent courses.

Children weighing less than 20 kg , the dosage of Cortexin is calculated individually, based on the ratio of 0.5 mg per 1 kg of weight. The calculated dose is administered to the child once a day for 10 days. If necessary, courses of therapy are repeated every 3 to 6 months until the desired result is obtained.

If for any reason an injection of Cortexin was missed, then the next day you should not administer a double dose. It is necessary to administer the usual single dosage of the drug and lengthen the course of therapy so that it consists of 10 injections.

Rules for injections with Cortexin

• The anterolateral surface of the thigh in the upper third;
• Outer upper third of the shoulder;
• The anterior wall of the abdomen (in non-obese people).

Having selected the injection area, you need to treat it with a cotton swab soaked in an antiseptic, for example, 70% alcohol, chlorhexidine, Belasept, etc. Then you should insert the needle into the thickness of the tissue, holding it perpendicular to the surface of the skin. The needle is inserted so that about 3–4 mm of free space remains between the skin and the needle holder. After this, slowly pressing on the piston, release the solution into the tissue and remove the syringe. After the injection is completed, the injection site is wiped again with a cotton swab moistened with an antiseptic.

For each subsequent injection, 1 cm is removed from the mark of the previous injection. That is, there must be a distance of at least 1 cm between the injection marks. All injections required for a course of therapy can be made in the same area of ​​the body, but keeping between them distance 1 cm.

Use during pregnancy and breastfeeding

Cortexin should also not be used when breastfeeding. If for any reason a nursing woman needs to undergo a course of treatment with Cortexin, then she should stop feeding the child for the period of therapy and transfer him to artificial milk formula. One day after the last injection, you can continue breastfeeding the baby if you managed to maintain lactation.

Impact on the ability to operate machinery

Overdose

Interaction with other drugs

Cortexin for children

Cortexin is most often prescribed to school-age children to improve cognitive functions, that is, memory, thinking and attention. As a rule, the drug is given to schoolchildren when it is difficult to master educational material, low learning ability, slurred and monotonous speech, etc. The drug is also prescribed to children of any age to eliminate the consequences of various adverse effects on the brain, such as trauma, hypoxia, stress, etc.

Cortexin - instructions for use in children

Let's look at an example of how to correctly calculate the dosage of Cortexin for a child and convert milligrams of lyophilisate into milliliters of the finished solution.

For example, a child has a body weight of 15 kg, which means he needs 0.5 * 15 = 7.5 mg of Cortexin lyophilisate per injection. Next, you need to decide how many milliliters of solution you will use to dilute the Cortexin lyophilisate, since this is important for further calculations. Let’s assume that 1 ml of solution will be used to dilute the lyophilisate. Then 1 ml of the prepared solution of adult Cortexin will contain 10 mg of lyophilisate. But a child does not need all 10 mg of lyophilisate for injection, but only 7.5 mg. This means that it is necessary to calculate how many milliliters of the finished Cortexin solution, obtained by mixing the entire volume of lyophilisate with 1 ml of solvent, contains only 7.5 mg of the active component. To do this, we create a proportion:
1 ml of solution – 10 mg of lyophilisate;
X ml of solution – 7.5 mg of lyophilisate;
Using the proportion, we make up the equation: X = 7.5 mg * 1 ml / 10 mg; X = 0.75 ml.

This means that 7.5 mg of lyophilisate is contained in 0.75 ml of solution obtained by mixing the entire volume of Cortexin powder present in the bottle with 1 ml of solvent. Thus, to produce an injection, the child will have to dilute the entire lyophilisate in the vial and draw only 0.75 ml into the syringe. The remaining solution should be discarded, and for the next injection, dilute the lyophilisate from a new bottle.

The dosage and volume of the finished solution for injection are calculated in a similar way for a child of any body weight. You can use the given diagram, substituting your own numbers into it. When using children's Cortexin, dosages are calculated in exactly the same way, only taking into account the fact that one bottle of lyophilisate contains not 10 mg of the active substance, but 5 mg.

Parents must remember that the lyophilisate in the vial cannot be divided into parts, you should dilute it all. And only then, from the entire solution, select the volume required for a single administration to the child. The remaining solution should be thrown away and not stored, and for each subsequent injection, the entire lyophilisate from one bottle should be diluted again, the required volume should be taken, administered to the child, etc.

The duration of therapy with Cortexin is 10 days, and it is recommended to give injections in the first half of the day (before 14.00 - 15.00), since the drug has a stimulating effect, as a result of which, when administered in the evening, it can cause difficulty falling asleep. Courses of therapy can be repeated, maintaining intervals between them of 3–6 months, and each time recalculating the dosage based on the child’s actual body weight.

To dilute the lyophilisate for the production of Cortexin injections, children are recommended to use saline solution or sterile water for injection, and not novocaine. The fact is that novocaine can provoke allergic reactions and reduce the severity of the therapeutic effect of Cortexin. For children, it is optimal to dilute adult Cortexin (10 mg) with 1 ml of solvent, and for children – 2 ml.

Cortexin injections for children should be performed strictly intramuscularly according to the same rules as for adults. In addition, to reduce the pain of the injection, it is necessary to take thin needles and inject the solution very slowly, and then, according to the children, they practically do not feel pain.

Side effects

To improve brain activity, activate metabolic processes in brain tissue and eliminate various neurological pathologies, children are often prescribed nootropic medications. One of them is a drug from the domestic pharmaceutical company Geropharm, called Cortexin. When is it prescribed to a child and how to properly treat children with this medication?

Release form and composition

Cortexin is available in pharmacies in only one form - injectable. It is sold in boxes containing 10 glass bottles containing white or yellowish-white powder (lyophilisate). It may also appear as a porous, homogeneous yellowish or white mass.

The main ingredient of such a powder is polypeptide fractions, the molecular weight of which does not exceed 10 thousand Da. Such protein molecules with small length and mass are a water-soluble complex and are also called cortexin. Their quantity in one bottle can be 5 mg or 10 mg. These polypeptides are extracted from the brain of pigs or cattle (from the cortex).

Glycine is added to the medication as a stabilizer. Its dosage is 6 mg in bottles with 5 mg of the active complex (in total the drug contains 11 mg, and the volume of the bottle is 3 ml) and 12 mg in the drug with 10 mg of cortexin (in total there is 22 mg of powder inside, and the volume of the bottle is 5 ml) .

Operating principle

After injection, low molecular weight protein molecules of Cortexin pass through the blood-brain barrier and have the following effect on the brain:

• Both nerve cells and neurotrophic factors are stimulated, due to which information is transmitted better and faster along the fibers, and the balance of excitatory and inhibitory mediators is normalized.
• They protect neurons from various damaging factors, for example, from hypoxia, free radicals or calcium ions. This therapeutic effect of the drug is called cerebro- or neuroprotective. It makes nerve cells more resistant to any external influences, including stressful situations and taking various psychotropic medications.
• They activate metabolic processes in brain tissue and accelerate the recovery of nerve cells, resulting in improved overall tone and central nervous system functions.
• They have a positive effect on the ability to learn new material and work. This is the action that is called nootropic. It consists in improving the functions of thinking, among which attention and memory are especially important.
• Reduce convulsive activity in cases of brain tissue damage. Thanks to this effect, the use of Cortexin helps prevent the occurrence of seizures.
• They slow down oxidative processes in brain cells, that is, they act as an antioxidant.

Indications

Cortexin in childhood is prescribed:

• For traumatic brain injuries or to eliminate their consequences.
• For encephalitis or encephalomyelitis.
• With speech delay.
• For epilepsy.
• For neuroinfections caused by viruses or bacteria.
• With delayed psychomotor development.
• For circulatory disorders in the brain.
• For encephalopathy.
• With hydrocephalic syndrome.
• For problems with memory or attention.
• With asthenia.
• For children with cerebral palsy.

At what age is it allowed?

Cortexin can be prescribed to children of any age, including infants in the first year of life. This remedy is used even in premature infants, if there are serious indications for this, for example, in case of birth trauma, neuroinfection or hypoxia during childbirth.

Contraindications

The drug is not used in children with intolerance to its components. There are no other contraindications for this medicine. However, if your baby gets sick during the course of therapy, you should definitely consult a doctor and discuss stopping the medication. As a rule, for colds, flu and other acute respiratory viral infections, injections are not given, but treatment is postponed until the child has fully recovered.

Side effects

Sometimes treatment with Cortexin provokes an allergic reaction, such as a rash or itchy skin. If the injection site turns red, rashes appear, or the child complains of pain and burning, you should show the baby to a doctor.

Instructions for use

Cortexin is administered only intramuscularly. Before injecting, the lyophilisate must be diluted. The powder is diluted immediately before the injection. For this purpose, use sterile water intended for injection, as well as sterile saline solution.

The medication can also be diluted with a 0.5% solution of novocaine, but this solvent is used much less frequently. Although it reduces the pain of the procedure, when diluted with an anesthetic, the therapeutic effect of Cortexin decreases, and the risk of an allergy to the injection increases. For this reason, the use of novocaine is recommended only if the child has a hard time with the injections and they are very painful for him, and the little patient is not allergic to novocaine.

To dilute Cortexin, you must first draw up 1-2 ml of solvent with a sterile syringe, then remove the foil from the lyophilisate bottle and pierce the rubber stopper. Next, the solvent should be carefully released into the bottle so that foam does not form (to do this, it is recommended to direct the liquid stream towards the wall so that the solvent slowly flows onto the powder).

Having released all the water or saline solution and without removing the needle, you need to gently shake the bottle until the powder is completely dissolved. As soon as the solution becomes homogeneous and transparent, it is drawn back with the same syringe, and then an intramuscular injection is performed.

It is important to remember that for one injection the entire lyophilisate is diluted, and then the required volume of medication is collected. Dividing the powder into parts and then diluting only one of them is unacceptable.

The medication is recommended to be injected into the muscles of the shoulder or thigh. To reduce pain, the injection should be performed with a thin needle and the medicine should be injected very slowly. The next injection is given at least 1 cm away from the previous one.

Dosage

• For babies weighing up to 20 kg, the dose should be calculated by weight. To do this, the number of kilograms is multiplied by 0.5, for example, if a child weighs 8 kg at 10 months, then he needs 8x0.5 = 4 mg of cortexin per day. For such a baby, take bottles with 5 mg of the active ingredient, dilute with 2 ml of water for injection and administer 1.6 ml of the finished medicine to the baby (it is from this amount that the baby will receive 4 mg of the active complex). If the medication is diluted with 1 ml of saline solution or sterile water, then the child needs to administer 0.8 ml. The remainder of the drug is discarded.
• For a child weighing more than 20 kg, Cortexin is prescribed 10 mg per day. One bottle with this content of the active complex is diluted with 1 ml of water for injection or saline solution.
• The drug is administered once daily for ten days. It is recommended to give the injection in the first half of the day, because the medication has a stimulating effect. After a 10-day course of treatment, a break is taken for 3-6 months, after which the therapy can be repeated.
• For stroke, 2 injections of 10 mg are given daily. One of them is given in the morning, and the second - in the daytime, since an injection given in the evening can interfere with falling asleep.
• If for some reason the injection was missed, the next day there is no need to administer the drug at a double dose. In such a situation, the course is extended so that there are 10 injections in total.

Overdose

During the entire period of use of the medication in children, no cases of overdose were registered.

Drug interactions

Cortexin does not have any negative effect on other medications, so it can be used in conjunction with various medications. In this case, the drug cannot be mixed in the same syringe with any other solutions other than approved solvents. If several injections are prescribed, they should be administered as separate injections.

Terms of sale and storage

Purchasing Cortexin in pharmacies is possible only if you have a prescription for such a medication obtained from a pediatrician, neurologist or other specialist. The average price of 10 ampoules containing 10 mg of the active compound is 1,200 rubles. Separately, you should purchase a package with 1-2 ml ampoules of saline solution or water for injection.

It is recommended to keep the box with bottles at home at a temperature below +25 degrees in a place where the product will be hidden from sunlight and inaccessible to children. The shelf life of sealed bottles with powder is 3 years from the date of manufacture. The diluted medicine can be stored for no longer than 20 minutes. If, for any reason, more time has passed after mixing with the solvent, the syringe with the drug must be thrown away, and then diluted and the lyophilisate drawn from a new bottle.

Reviews

There are many good reviews about the treatment of children with Cortexin. In them, mothers note that after a course of injections, the child speaks better, easily learns poems, remembers new information, becomes less nervous, and expands his vocabulary. In the smallest children, the medicine accelerates motor development. According to parents, after injections, babies quickly learn to roll over on their tummy, sit, stand up, hold a spoon, master crawling, and so on.

When treating schoolchildren, mothers confirm the positive effect of Cortexin on thinking, attention and memory. In children of this age, the drug effectively helps with low learning ability, difficulties with learning material, and problems with speech. Doctors also emphasize that injections help eliminate the negative effects of stress, hypoxia, trauma and other factors on the brain. However, many doctors, including Komarovsky, classify Cortexin and other nootropics as medications whose effectiveness has not been proven.

The medicine is well tolerated by most young patients. Local reactions to injections occur very rarely and often when the powder is diluted with novocaine. Negative reviews complain about the high cost of the course of treatment, severe pain of injections, and in some children they note the absence of any positive effect on the nervous system. Also, many parents do not like that the product is only available in injection form, so they choose analogues in tablets.

Analogs

Instead of Cortexin, children may be prescribed other drugs with similar therapeutic effects:

• Cogitum. This medicine in the form of a sweet banana solution in ampoules is in demand for cerebral cancer, asthenia, perinatal damage to the central nervous system, neuroses and other problems. It is prescribed from the age of 7.
• Cerebrolysin. The action of this medicine in ampoules for intravenous or intramuscular injections is ensured by peptides that are obtained from the brain of pigs. The drug is used in children with traumatic brain injuries, organic or metabolic diseases of the brain. It is prescribed to children at any age if there are indications for it.

• Latin name: Cortexin
• ATX code: N06BX
• Active substance: Livestock cerebral cortex polypeptides
• Manufacturer: Geropharm LLC, Russia

Compound

Release form

The drug is available in the form of a sterile lyophilized powder for the preparation of a solution for intramuscular administration.

The cardboard packaging is completed with two blister packs, each containing 5 bottles of lyophilisate, and instructions for use.

In pharmacies you can buy Cortexin 10 mg No. 10 and Cortexin 5 mg No. 10.

Cortexin 10 mg is available in 22 mg doses in 5 ml bottles. The product is intended for the treatment of adult patients.

Cortexin 5 mg was created specifically for use in pediatrics. It is available in 11 g bottles with a capacity of 3 ml.

pharmachologic effect

Cortexin belongs to the group nootropic and gamkergic drugs , affecting mainly CNS . Against the background of its use, the following are noted:

• nootropic ;
• neuroprotective ;
• antioxidant ;
• tissue-specific effects.

Pharmacodynamics and pharmacokinetics

Cortexin is a bioregulator with a polypeptide structure, which is a complex of water-soluble neuropeptides . The molecular weight of these polypeptide fractions does not exceed 10 thousand daltons, which allows them to penetrate the physiological barrier separating central nervous And circulatory system .

The mechanism of action of the drug is realized through:

• activation of regulatory , neurons And brain neurotrophic factors ;
• normalization of the ratio amino acids , performing mediator functions of excitatory and inhibitory types of action, as well as important brain neurotransmitters And serotonin ;
• moderately expressed GABA-ergic effects;
• reducing the level of paroxysmal (attack-like) convulsive activity brain and the ability to normalize the indicators of its bioelectric activity;
• preventing the formation of oxidative degradation products lipids (free radicals).

The nootropic effect of Cortexin is accompanied by improvement higher brain functions , improving memory, increasing learning ability and stress resistance.

The neuroprotective effect is manifested in the ability of the product to increase tissue resistance brain to the damaging effects of various endogenous neurotoxic factors and reduce the toxic effects of neurotropic substances.

Antioxidant action manifested in the drug’s ability to influence oxidative stress (cell damage provoked by oxidative processes) and increase the survival rates of neurons under conditions of oxygen starvation.

The mechanism of this action is associated with the suppression of free radical processes and peroxide oxidation of cell membrane lipids , as well as with the correction of oxygen-dependent pathological conditions.

As a result: the destruction process slows down cell membranes , microcirculation improves, decreases permeability of vessel walls , the level of blood levels and triglycerides .

The tissue-specific effect of the drug is associated with an increase in intensity CNS neurons And PNS , stimulation of reparative processes in CNS , improvement of functional state cerebral cortex and general tone somatic and autonomic nervous system .

Pharmacokinetic characteristics cannot be determined, since the disintegration time of the L-series amino acids and neuropeptide fractions included in the active substance Cortexin is no more than 3 minutes.

This makes it impossible to establish the rate and extent of absorption of peptide residues, their distribution among various organs and tissues, as well as the rate and routes of their excretion from the body.

Indications for use of Cortexin: for which the medicine is prescribed to adults and children

Indications for use of the drug are:

• provoked bacteria or viruses infectious diseases of the nervous system ;
• conditions accompanied by a violation blood circulation in the brain ;
• TBI and its consequences;
• diffuse brain lesion syndrome different nature of origin;
• cerebral (suprasegmental) autonomic disorders .

In combination with other drugs, the drug is prescribed for treatment, as well as for the treatment acute and chronic inflammatory diseases of the brain and/or spinal cord of various etiologies.

For children, indications for the use of Cortexin are reduced learning ability, memory and thinking disorders, child retardation syndrome psychomotor and speech development (ZPRR), various forms cerebral palsy .

Contraindications

The drug is contraindicated in patients with hypersensitivity to cortexin and/or glycine.

Clinical studies to establish the effect of the drug on the body of a pregnant woman and the developing fetus have not been conducted. For this reason, the drug is not recommended for use at any time.

Since there are no data from clinical studies regarding the use of the drug during this period, if it is necessary to prescribe Cortexin, it is recommended to stop breastfeeding.

Side effects of the drug

Potentially possible side effects are those caused by individual sensitivity to the components included in the drug.

Cortexin injections, instructions for use (Method and dosage)

The drug is intended for injection into the muscle.

How to dilute Cortexin?

Before injection, the powder contained in the bottle should be diluted with one or two milliliters of a 0.5% solution (), saline solution (isotonic sodium chloride solution (0.9%)) or water for injection.

To prevent the formation of foam, they try to direct the needle towards the wall of the bottle.

How to inject a child with Cortexin?

Cortexin can be prescribed from the first days of life. In some situations, parents have to give their child injections themselves. And here questions arise about how to properly inject Cortexin and what is the best way to dilute the powder.

Before giving the injection, water for injection is drawn into the syringe, novocaine or saline solution , then pierce the lid of the bottle and pour the collected liquid into it.

The syringe should be removed (the needle remains in the cap) and the contents of the bottle should be thoroughly shaken until the powder is completely dissolved. After this, the syringe is reattached and the required amount of solution is drawn into it.

For an injection, it is better to take a new needle, since the needle with which the solvent for the lyophilisate was injected may already be fairly dull.

The medicine is administered slowly, as rapid administration can cause very severe pain.

For babies up to six months old, an intramuscular injection is given into the anterior surface of the thigh (so as not to accidentally damage the sciatic nerve).

For children, especially very young children, all injections are given with saline or water for injection. Injections with novocaine less painful than injections saline solution , however, dilute the drug novocaine is permitted only if there is firm confidence that this will not cause allergic reaction The child has ( novocaine capable of giving the strongest allergies And convulsions ).

Like others neurometabolic drugs , Cortexin is recommended to be injected before 12 noon, given its activating effect and ability to provoke psychomotor agitation .

Instructions for use of Cortexin for adults

Adult patients are given Cortexin injections once a day, daily for ten days, at a dose of 10 mg.

At massive ischemic stroke (MII) in the acute phase, as well as in the early recovery period, the indicated dose is recommended to be administered to the patient twice a day (morning and evening) for ten days. After ten days, the course should be repeated.

Instructions for use of Cortexin for children

In pediatric practice, the medicine is used to treat children from the first days of their life.

For patients whose weight does not exceed 20 kg, the drug is prescribed at a dose of 0.5 mg/kg body weight. For patients weighing more than 20 kg, a dose of 10 mg is indicated.

The duration of treatment is ten days. If necessary, after three to six months the patient may be prescribed a second course.

The drug extremely rarely causes side effects, has almost no contraindications and can be used to treat even newborn babies. Its main disadvantage is considered to be its release form: Cortexin is not available in tablets, and this partly complicates its use in children, if the latter require several courses.

Overdose

To date, there are no reports of side effects that have developed as a result of an overdose of Cortexin.

Interaction

The drug is incompatible with drugs that have a peptide structure.

Terms of sale

The drug belongs to the category of prescription drugs and should be dispensed from pharmacies only with a doctor's prescription.

Storage conditions

Cortexin should be stored in a dry place, protected from sunlight, at a temperature of 2 to 20°C.

Best before date

Suitable for use within 36 months from the date of manufacture.

special instructions

The drug is produced exclusively in the form of a lyophilisate; Cortexin is not produced in tablets.

The drug should not be mixed in the same syringe with any other medications.

Analogues of Cortexin

Cortexin analogues in tablets: Armadin And Armadin Lon G, Borizol , Rilutek , .

Analogues of Cortexin in ampoules: Armadin , Mexiprim , Neurotropin , Nikomex , Nucleo CMF Forte , Cytoflavin .

Cortexin or Cerebrolysiin - which is better?

Studies conducted on laboratory rats showed that Cortexin, when administered intraperitoneally and intraperitoneally, lateral ventricle of the brain have a similar effect.

A comparative analysis of the central effects of the drugs led to the conclusion that, despite all their similarities, Cortexin is more active.

At the same time, it provokes a much smaller number of adverse reactions and can be used from birth (whereas Cerebrolysin in pediatric practice it is used if there are justified indications).

According to some patients, injections Cerebrolysin less painful compared to Cortexin injections.

Cortexin for children

The instructions for use of Cortexin for children permit the use of this drug from the first days of a child’s life.

Doctors' reviews of Cortexin for children confirm the manufacturer's statements that the drug practically does not cause adverse reactions and does not have any teratogenic and carcinogenic effects and is well tolerated by patients.

Its use in neurology, neonatology and pediatrics can improve the child’s behavior and his general condition with various types of tones, normalize memory function and speech, and relieve headaches.

Reviews about Cortexin

Cortexin is a drug widely used in neurological practice. Reviews of Cortexin for adults, which can be found on numerous thematic forums, indicate the effectiveness of this drug for treating patients of all ages (both infants and the elderly).

Taking the drug allows you to speed up the recovery process after injuries and, and in older people it stimulates work brain , increases the ability to remember and concentrate, and also prevents a decrease in intellectual abilities.

Reviews of Cortexin for children allow us to conclude that the drug is most often prescribed to children who have certain deviations in neuropsychic development. In particular, the indications for use of the drug are cerebral palsy And brain damage that occurred in the prenatal period (close to the date of birth) or directly during childbirth.

Injections for children - and reviews of Cortexin confirm this - can achieve significant improvements: after a course of treatment with the drug, the child becomes calmer, he has an improvement in brain activity, an increased interest in learning, and improved memory and speech.

The use of the drug for infants (in particular, for newborns born ahead of schedule) allows you to notice obvious improvements in a fairly short time, which are manifested in the child’s calmer behavior or the emergence of new skills (for example, the ability to independently roll over from his back to his tummy and back).

Mothers whose children were prescribed Cortexin note that after the course of treatment the child literally “came to life before our eyes.” Many consider the advantages of the drug to be the absence of side effects and low toxicity of the drug. The disadvantages most often cited are the rather high price of the product and the pain of the injections.

According to statistics, perinatal pathologies of the central nervous system are diagnosed in approximately half of newborn babies. As such children grow older, problems with the brain transform into delayed physical and mental development, inappropriate behavior, and even cerebral palsy. Timely therapy helps the brain compensate for damage received during childbirth or during the prenatal period. One of the medicines that helps children gain health is Cortexin.

Effect of the drug

Cortexin is a nootropic consisting of neurotransmitters and polypeptides that have a beneficial effect on the cerebral cortex.

This drug has the following effects on the body:

1. Tissue-specific: Cortexin activates metabolism, thereby improving the activity of the central and peripheral nervous systems. Thanks to this, brain activity is stimulated and the nervous system as a whole is healed.
2. Neuroprotective: the drug protects the brain from the influence of toxic substances, in particular psychotropics, calcium ions, free radicals, etc. At the same time, the brain becomes resistant to adverse external influences and begins to work much more productively.
3. Antioxidant: the drug slows down and prevents lipid oxidation, resulting in more brain cells surviving when oxygen is deprived. At the same time, blood microcirculation improves and triglycerides and cholesterol levels are normalized.
4. Nootropic: the drug stimulates brain activity, improving cognitive performance. As a result, patients develop stress resistance, memory improves, attentiveness increases and good learning ability appears.
5. Anticonvulsant: thanks to Cortexin, an optimal ratio between inhibitory and excitatory amino acids is established in the human brain, and the amount of serotonin and dopamine returns to normal. This effect is achieved by normalizing the bioelectrical activity of brain neurons.

Release forms and composition

Cortexin is available in powder form, from which an injection solution is prepared. One bottle may contain 5 or 10 mg of the active ingredient. For the treatment of children, a dosage of 5 mg is used. Each bottle contains 11 mg of medicinal substance: 5 mg of cortexin and 6 mg of glycine.

Attention! Cortexin is available only in the form of a lyophilized powder, from which an injection solution is prepared. Tablets and capsules with the same name are fake.

Externally, Cortexin is a white or yellowish powder, which is an extract made from the brain of calves and piglets. The molecules of these proteins are so small in length and mass that they can cross the blood-brain barrier and go straight into the human brain.

Indications, contraindications and possible side effects

Cortexin can be used by patients of any age, even infants. It is actively prescribed for disorders of brain activity, in particular for the following pathologies:

• traumatic brain injuries;
• asthenic syndrome;
• neuroinfections of a viral or bacterial nature;
• inflammatory diseases of the brain and spinal cord;
• cerebrovascular accident;
• encephalopathy;
• hydrocephalic syndrome;
• epilepsy;
• syndrome of diffuse brain damage;
• cerebral autonomic disorders;
• cognitive impairment;
• delayed psychomotor and speech development;
• infantile cerebral palsy.

In pediatric practice, Cortexin is often used to correct inappropriate behavior, as well as in cases of reduced learning ability, poor memory, and inattention. Neurologists note the high effectiveness of the drug for such problems as delayed speech development.

Cortexin is one of the most popular drugs in pediatric intensive care units: it is used to treat newborns with perinatal lesions of the central nervous system who are in critical condition.

As a rule, Cortexin is well tolerated by young patients. As side effects, allergic manifestations are possible in case of hypersensitivity to the components of the drug. Apart from individual intolerance, there are no restrictions on taking nootropics in pediatric practice.

Instructions for use: how to dilute and inject Cortexin

Before using a nootropic, a competent neurologist must prescribe an electroencephalogram for a small patient - a study of the electrical activity of neurons in the brain. If it shows the presence of epiactivity, you should not inject Cortexin, since in this case you can only harm the brain.

The solution for injection is prepared as follows:

1. Draw 1–2 ml of water for injection or isotonic sodium chloride solution (saline) into a sterile syringe.
2. Use a syringe needle to pierce the rubber stopper of the Cortexin bottle and pour liquid into it. To avoid the formation of foam, the needle is directed towards the wall.
3. The contents of the bottle are gently shaken until the powder is completely dissolved.
4. The required amount of solution is drawn into the syringe, and the needle used to pierce the bottle is replaced with a new one.
5. They inject the drug very slowly, because too fast an injection causes pain.

Sometimes doctors recommend reducing the pain of the injection by diluting the powder not with saline solution, but with novocaine (0.5%). This method can only be used if there is firm confidence in the absence of side effects. Since novocaine often provokes severe allergic reactions and even seizures in children, many pediatricians do not approve of diluting Cortexin with this drug.

The diluted solution should be used immediately. If it has stood for more than half an hour, it is better to pour it out and prepare a fresh portion of the medicine.

As a rule, injections are given in the buttock, but for babies under six months it is better to place them in the front surface of the thigh. Otherwise, there is a high probability of damage to the sciatic nerve. In this case, each subsequent injection must be at a distance of at least 1 cm from the site of the previous injection of the medicine.

Attention! Like all nootropics, Cortexin can cause severe agitation and difficulty sleeping at night, so injections should be done before 13:00.

The dosage of the drug is calculated based on the child’s body weight. The course of treatment usually includes 10 daily injections, and the medication can be reused after 3-6 months. If your baby has mild cold symptoms, you are allowed to continue giving injections. If there is a very high temperature and poor general health, therapy should be stopped. The final decision on canceling or extending the course should be made by the doctor.

How to replace Cortexin

There are no exact analogues of Cortexin based on the active substance, but there are many nootropic drugs with a similar effect on the brain.

Under no circumstances should you independently replace Cortexin prescribed by your doctor with other drugs, even if they are cheaper and more accessible. Only a specialist can do this.

Cortexin analogues - table

Other nootropic drugs for children - gallery