Instructions on what drotaverine helps with. Drotaverine: what it helps with, indications and instructions for use, reviews With renal or liver failure

Active substance

Drotaverine hydrochloride (drotaverine)

Release form, composition and packaging

◊ Pills yellow with a greenish tint, round, flat-cylindrical in shape, with a chamfer and a notch.

Excipients: potato starch - 30.1 mg, lactose monohydrate (milk sugar) - 60.1 mg, (polyvinylpyrrolidone) - 5.8 mg, talc - 2.6 mg, magnesium stearate - 1.4 mg.

10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (4) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.
100 pieces. - polymer jars (1) - cardboard packs.

pharmachologic effect

Myotropic antispasmodic, isoquinoline derivative. Inhibits phosphodiesterase (PDE) IV, which leads to the accumulation of intracellular cyclic adenosine monophosphate (cAMP) and, as a result, inactivation of the light chain of myosin kinase, resulting in relaxation of smooth muscles.

Regardless of the type of autonomic innervation, drotaverine acts on smooth muscles in the gastrointestinal tract, biliary, genitourinary and vascular systems. In the myocardium and blood vessels, the enzyme that hydrolyzes cAMP is PDE III, which explains the absence of serious side effects from the cardiovascular system (CVS) and an unpronounced therapeutic effect on the CVS.

The presence of a direct effect on smooth muscles allows it to be used as an antispasmodic in cases where drugs from the group of m-anticholinergics are contraindicated (angle-closure glaucoma, prostatic hyperplasia).

Pharmacokinetics

When taken orally, absorption is high, half-life is 12 minutes. Bioavailability – 100%. Evenly distributed in tissues, penetrates smooth muscle cells. The time to reach Cmax in the blood is 2 hours. Protein binding is 95-98%. It is mainly excreted by the kidneys, and to a lesser extent – ​​with bile. Does not penetrate the blood-brain barrier.

Indications

- spasm of smooth muscles of the urinary and biliary organs (renal colic, pyelitis, tenesmus, biliary colic, intestinal colic, dyskinesia of the biliary tract and gallbladder of the hyperkinetic type, cholecystitis, postcholecystectomy syndrome);

- spasm of smooth muscles of the gastrointestinal tract (usually as part of combination therapy): pylorospasm, gastroduodenitis, peptic ulcer of the stomach and duodenum, spastic constipation, spastic colitis, proctitis;

- tensor headache;

- dysmenorrhea, threatened miscarriage, threatened premature birth, postpartum contractions;

- when conducting some instrumental studies, cholecystography.

Contraindications

- severe liver and kidney failure;

- severe failure (low cardiac output syndrome);

- lactation period;

- hypersensitivity to the components of the drug.

This dosage form is not used in children under 3 years of age.

Due to the presence of lactose monohydrate (milk sugar) in the drug, its use is contraindicated in cases of congenital lactose intolerance, lactase deficiency, and glucose-galactose malabsorption.

Drotaverine should be taken with caution used for arterial hypotension, severe atherosclerosis of the coronary arteries, prostatic hyperplasia, angle-closure glaucoma, and during pregnancy.

Dosage

For adults prescribed orally 40-80 mg (1-2 tablets) 2-3 times/day. The maximum daily dose is 240 mg.

Children aged 3 to 6 years- in a single dose of 20 mg, maximum daily dose – 120 mg (in 2-3 doses); V age from 6 to 12 years single dose – 40 mg, maximum daily dose – 200 mg; frequency of use – 2-5 times/day.

Side effects

Dizziness, headache, insomnia, palpitations, decreased blood pressure, allergic reactions, nausea, constipation, feeling hot, sweating.

Overdose

There is no data on overdose regarding the drug.

Drug interactions

When used simultaneously, the antiparkinsonian effect of levodopa may be weakened.

Enhances the effect of bendazole and other antispasmodics (including m-anticholinergics), the decrease in blood pressure caused by tricyclic antidepressants, quinidine and procainamide.

Reduces the spasmogenic activity of morphine.

Increases the severity of the antispasmodic effect of drotaverine.

special instructions

In the treatment of gastric and duodenal ulcers, it is used in combination with other drugs usually prescribed for the treatment of this group of diseases of the esophagus, stomach and duodenum.

Impact on the ability to drive vehicles and operate machinery

When taken orally in therapeutic doses, drotaverine does not affect the ability to drive a car or perform work that requires increased attention. If any side effects occur, the issue of driving vehicles and operating machines requires individual consideration.

Antispasmodic drugs are widely used to dilate blood vessels and relieve spasms of the smooth muscles of organs. Which is better - Drotaverine or No-shpa? This question interests many patients who want to know why doctors often prescribe. The action of both drugs is aimed at eliminating spasms and pain. Moreover, both medications have the same dosage of the active drug substance drotaverine. But these medications also have some differences that every person needs to know.

Drotaverine and Nosh-pa - comparative characteristics

Antispasmodics eliminate spasms of a wide variety of internal organs and help quickly eliminate pain. Painful sensations in the abdomen can be caused by a pathological process - inflammation in the biliary tract, cystitis, gastrointestinal infection.

Spasms cause irritable bowel syndrome, enteritis, ulcers, cholecystitis. For many pregnant women, doctors prescribe antispasmodics to restore uterine tone and prevent miscarriage. A table that clearly shows the characteristics of both medications will help you understand the features of both drugs.

Antispasmodic drugs are prescribed to eliminate smooth muscle spasms. During pregnancy, it is prescribed to relieve pain and in case of threat of miscarriage, but only in special cases to relieve high risks. Drotaverine is also indicated for severe coughs to relieve spasms, headaches and menstrual pain. During bronchospasm, the medicine helps relieve a painful attack and restore breathing.

Good to know Drotaverine is used to relieve pain and spasms. He does not participate in the process of eliminating the cause of the disease. In some cases, doctors recommend taking Drotaverine or Noshpa to calm you down before bed. The drug can be used in extreme heat. Which is better – Drotaverine or Noshpa? Doctors prefer to prescribe the imported drug Noshpa, based on its safer effects.

Differences between the two drugs

In terms of their effects and properties, both drugs are almost identical. Despite similar pharmacological properties, the drugs have the following differences:

1. Manufacturer. No-shpa is produced by a well-known Hungarian company, while Drotaverin is a Russian analogue.
2. Drotaverine contains crospovidone.
3. Large doses of Drotaverine can cause disturbances in cardiac activity and even cardiac arrest. Noshpa is safer to use.
4. Drotaverine can be taken by children from 3 years of age. Noshpa is recommended for use from 5-6 years.
5. Drotaverine is cheaper than the imported drug Noshpa.

Important! The use of the substance drotaverine can be dangerous in case of low blood pressure and hypotension. Both drugs lower blood pressure and have a vasodilatory effect. Drotaverine can be taken during a hypertensive crisis to lower blood pressure. Injections of Noshpa and Drotaverine are prescribed in extreme cases when swallowing the tablet is impossible for some reason.

Common features of the two drugs

What is better Drotaverine or Noshpa? Drotaverine is an analogue of the more expensive imported medicine No-shpa. Both products contain the same amount of active drug. The drugs are almost identical in their pharmacological properties. Their action is aimed at eliminating spasms and pain. Medicines do not disrupt the functions of the central nervous system, relax smooth muscles and soothe. Intravenous or intramuscular injections may impair the patient's psychomotor function.

Drotaverine belongs to the group of myotropic antispasmodics. In its structure and effect on smooth muscles, the drug is similar to papaverine, but has a more pronounced therapeutic effect.

Reduces the tone of smooth muscles of internal organs and intestinal motility, dilates blood vessels. Most often, the medication is prescribed for various spasmodic pains, although it is not an analgesic.

On this page you will find all the information about Drotaverine: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Drotaverine tablets. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Myotropic antispasmodic.

Conditions for dispensing from pharmacies

Available without a prescription.

Prices

How much does Drotaverine cost? The average price in pharmacies is 190 rubles.

Release form and composition

The drug Drotaverine is available in the form of tablets intended for oral administration. The tablets are small, round, with a horizontal stripe on one side, light yellow in color with a slight greenish tint.

• The composition includes the active ingredient drotaverine hydrochloride. 1 tablet contains 40 or 80 mg of this substance.
• Additional elements: talc, potato starch, povidone, magnesium stearate, lactose monohydrate.

The drug is sold in blisters of 10 and 25 pieces in a cardboard pack, as well as in polymer jars of 20 or 50 pieces with a detailed description attached.

Pharmacological effect

Drotaverine is a myotropic antispasmodic. Drotaverine hydrochloride inhibits phosphodiesterase IV, resulting in the accumulation of intracellular cyclic adenosine monophosphate and subsequent inactivation of myosin light chain kinase, which results in smooth muscle relaxation.

Regardless of the type of autonomic innervation, the drug acts on the smooth muscles of the biliary, vascular, genitourinary systems, as well as the gastrointestinal tract. The direct effect of drotaverine hydrochloride on smooth muscles makes it possible to use it as an antispasmodic when m-anticholinergic drugs are contraindicated.

Indications for use

What does it help with? According to the instructions for Drotaverine, the use of the drug is aimed at reducing the tone of the smooth muscles of various internal organs; the use of tablets is indicated for:

1. Pielite;
2. by hyperkinetic type, renal and biliary colic, cholecystitis;
3. Pain syndrome caused by spasm of cerebral vessels, coronary arteries, endarteritis;
4. Threatened miscarriage or premature birth, prolonged dilatation or spasm of the uterine pharynx during childbirth, postpartum contractions;
5. Exacerbation of gastric and duodenal ulcers, pylorospasm, intestinal colic, proctitis, spastic colitis and constipation, tenesmus.

As part of the complex treatment of some of the listed diseases, the patient may be prescribed a solution of Drotaverine, if tablets cannot be used.

In addition, the use of the solution is indicated in the treatment of smooth muscle spasms:

1. Urinary tract, including nephrolithiasis, urethrolithiasis, pyelitis, bladder tenesmus;
2. Caused by diseases of the biliary tract, such as cholecystolithiasis, cholangiolithiasis, pericholecystitis, cholangitis, papillitis.

Contraindications

According to the instructions, Drotaverine is contraindicated in:

1. Severe heart failure;
2. Hypersensitivity to the components of the drug;
3. Severe liver and kidney failure;
4. Congenital lactose intolerance and lactase deficiency (due to the presence of lactose monohydrate in Drotaverine).

Drotaverine is not prescribed to children under 2 years of age and during lactation.

The drug should be used with caution in cases of low blood pressure, severe atherosclerosis of the coronary arteries, angle-closure glaucoma, prostatic hyperplasia, and during pregnancy.

Use during pregnancy and lactation

According to the instructions for use of drotoverine, it has been proven that this drug overcomes the hematological and placental barrier. In this case, the decision and prescription of this drug is made solely by the doctor, taking into account the benefits/risks for the mother and fetus.

Instructions for use

The instructions for use indicate that Drotaverine tablets should be taken without chewing.

The dosage and course duration are determined individually by the doctor.

• Adults are prescribed 40-80 mg (1-2 tablets) orally 2-3 times a day. The maximum daily dose is 240 mg.
• Children aged 3 to 6 years – in a single dose of 20 mg, maximum daily dose – 120 mg (in 2-3 doses); at the age of 6 to 12 years, a single dose is 40 mg, the maximum daily dose is 200 mg; frequency of use – 2-5 times/day.

Side effects

• rash;
• flushes of blood to the face;
• decreased blood pressure;
• Quincke's edema.

In isolated cases:

• rapid heartbeat, arrhythmia;
• headache, dizziness, insomnia;
• nausea, constipation.

Very rarely:

• bronchospasm;
• swelling of the nasal mucosa.

Overdose

Overdose manifests itself in the following symptoms:

• respiratory depression;
• vascular insufficiency;
• AV block;
• pale skin;
• sweating;
• nausea;
• vomit;
• paralysis of the respiratory center;
• cardiac arrest.

After 3 days, signs of liver damage may appear.

Treatment with gastric lavage and saline laxatives. In case of overdose, the patient should be under medical supervision.

special instructions

1. When taken orally in therapeutic doses, drotaverine does not affect the ability to drive a car or perform work that requires increased attention. If any side effects occur, the issue of driving vehicles and operating machines requires individual consideration.
2. In the treatment of gastric and duodenal ulcers, it is used in combination with other drugs usually prescribed for the treatment of this group of diseases of the esophagus, stomach and duodenum.

Drug interactions

1. Reduces the spasmogenic activity of morphine.
2. When used simultaneously, the antiparkinsonian effect of levodopa may be weakened.
3. Phenobarbital increases the severity of the antispasmodic effect of drotaverine.
4. Enhances the effect of papaverine, bendazole and other antispasmodics (including m-anticholinergics), the decrease in blood pressure caused by tricyclic antidepressants, quinidine and procainamide.

What does drotaverine, an effective and often prescribed drug with an antispasmodic effect, help with? It has a beneficial effect on smooth muscle tissue of various body systems, eliminating spasms and pain of both nervous and muscular etiology.

No serious side effects were noted, however, the drug should be prescribed exclusively by a doctor and taken by the patient under the supervision of a specialist.

Drotaverine: composition and pharmacological action

The drug is available in two dosage forms - a solution for intramuscular injection and tablets. The first includes:

• main component – ​​drotaverine hydrochloride;
• additional substances.

• drotaverine hydrochloride;
• lactose;
• additional components.

The drug is prescribed in tablet form more often than in injections.

After taking the drug, the active substance, which has antispasmodic activity, begins to affect the smooth muscles that are located in the genitourinary, biliary, cardiovascular and gastrointestinal systems. It significantly dilates the blood vessels, as a result of which oxygen begins to flow freely to the tissues and relieves spastic pain.

The components of the drug are capable of changing the permeability and potential of membranes in the tissue in a short period of time. They also reduce the activity of phosphodiesterase, a special enzyme.

After taking the tablet, the concentration of the active substance will reach its concentration in 50-60 minutes. Excreted from the body in urine, a small amount may be excreted in feces.

At the same time, the drug Drotaverine does not have any serious side effects in relation to the cardiovascular system, comparing favorably in this regard with many of its analogues. It is a drug with antispasmodic, vasodilating, myotropic and hypotensive effects.

Indications for use

Why Drotaverine can be prescribed by a therapist - the specialist must exclude individual intolerance to the components of the drug. The main indication for its use is to relieve a person of spastic pain that can occur with a variety of ailments. The drug may be prescribed if one of the following diseases has been diagnosed:

• frequent spasms with cholecystitis;
• stomach or duodenal ulcer;
• constipation, accompanied by spasms of smooth tissues that cause severe pain;
• colic due to gas retention;
• urethritis and cystitis;
• proctitis with pronounced pain;
• urethrolithiasis, pyelitis, nephrolithiasis - for these diseases, Drotaverine is prescribed as a local anesthetic drug, and it is part of a complex of medications.

Along with this, a medicine such as Drotaverine can be recommended for use during diagnostic procedures. For example, with cholecystography or similar.

Elimination of spasms is the main task of Drotaverine

Because the drug has a vasodilating effect, health care providers often prescribe it to relieve severe headaches that occur when cerebral vasospasms occur.

The use of Drotaverine in gynecology is widespread - it can help with spasms of the uterine pharynx or with prolonged dilatation. It is also prescribed for emergency childbirth if the specialist notes the risk of uterine spasms during the passage of the fetus.

Taking Drotaverine

The tablets are taken orally and should be taken with plenty of water. The frequency of meals, as a rule, does not have any effect, so there is not much difference in taking Drotaverine before or after meals. You can even do it on an empty stomach if a person suffers from severe pain or colic. The only inconvenience in this case is that the impact on the source of discomfort may begin a little later.

If the patient is suffering from too much pain that he cannot bear, the doctor may prescribe injections. They act much faster because they are administered intramuscularly. However, there are exceptions for patients with hepatic or renal colic - in them the drug is administered intravenously (slowly and in small portions). At the same time, there is a small risk of collapse (decreased blood supply to tissues, resulting in dysfunction of certain organs), so such procedures should be carried out exclusively in a supine state.

Important: it is prohibited to independently determine the duration of the course; only a specialist can choose how to take Drotaverine.

In particularly emergency cases, when vasospasm occurs and peripheral circulation is disrupted, Drotaverine can even be injected into an artery. The dosage must be carefully calculated by the doctor, and the drug should be administered even more slowly than intravenously.

Important: since the procedure is emergency, it should only be performed by a specialist. He will also be able to stop possible consequences (although, as a rule, they do not arise with the competent actions of a medical professional).

Compatibility of the drug with other drugs

If you use Drotaverine for the abdomen or in other cases in combination with other drugs that also have an antispasmodic effect, the effect of treatment may be enhanced, but such therapy should be carried out exclusively with the approval of the attending physician. Only a specialist will recommend medications that not only will not cancel the therapeutic effect of Drotaverine, but will also be able to make it more pronounced.

If you combine Drotaverine with tricyclic antidepressants, you should be prepared for the fact that arterial hypotension may increase many times over.

Patients who have been prescribed morphine should use Drotaverine with caution, as this drug greatly reduces the spasmogenic effect.

Overdose of Drotaverine

It is strictly forbidden to change the dosage prescribed by your doctor. An increase in the number of tablets or injections can provoke the development of atrioventricular block and lead to paralysis of the respiratory nerve, and the consequences of this can be extremely negative.

Possible side effects

Side effects from taking Drotaverine can occur in two cases: if it is taken for too long or if an allergic reaction to any component occurs. Such actions include the following manifestations:

• gastrointestinal tract - belching, constipation (or vice versa diarrhea), feeling of nausea, vomiting;
• central nervous system – fainting, severe headaches, disrupted daily routine, sleep disturbances;
• respiratory tract – swelling of the mucous membranes or bronchospasms;
• allergic reactions - Quincke's edema, dermatitis, rash, excessive sweating, itching;

All the described effects occur both when taking tablets and after injections, however, in the latter case, the patient may begin to develop depressed breathing, hypotension, or atrioventricular block (impaired conduction of electrical impulses from the atria to the ventricles).

It is important to follow the dosage of the drug, otherwise side effects may occur.

If you have headaches while taking Drotaverine or one of these side effects has been noted, and especially after injections, then the course of treatment should be stopped and you should consult your doctor. He will be able to either select analogues or prescribe additional medications to eliminate these actions.

Use during pregnancy and lactation

Drotaverine hydrochloride, the active substance, is able to penetrate the hematoplacental barrier. In other words, this component of the drug can have a direct effect on the fetus and in one way or another influence its development. A specialist may prescribe medication if the hypothetical benefit for the pregnant woman is higher than the potential threat to the child.

During breastfeeding, you should avoid taking Drotaverine, since it passes into mother's milk and, accordingly, is passed on to the baby. If refusal is impossible, then you need to think about temporarily stopping breastfeeding and transferring the child to artificial formula.

Often, medicine can be prescribed during premature birth, to relieve the tone of the uterus (this will stabilize the condition if there is a threat of miscarriage and will help promptly and without harm to the mother’s health to begin all the necessary auxiliary actions), as well as in the period after childbirth to stop contractions.

Whether Drotaverine can be prescribed to children is an open question. Some pediatricians and therapists are against therapy using this medicine and strongly recommend using it only after reaching 12 years of age, while others believe that the drug will not cause harm and prescribe it from 5-6 years of age. In any case, the treatment process with this medicine should be under the constant supervision of the attending physician.

Contraindications for use

As a rule, almost all medicines have certain contraindications, and Drotaverine is no exception. It should be used only after reading the instructions and according to the prescribed course of treatment. Contraindications are identical regardless of which form of the drug was chosen. These include:

• heart failure;
• cardiogenic shock;
• low blood pressure;
• atrioventricular block II or III degree;
• renal or liver failure;
• congenital lactase deficiency;
• malabsorption.

The drug is prescribed with caution to those diagnosed with atherosclerosis of the coronary arteries, the same applies to the usual form of atherosclerosis. It is not recommended for people whose professional activities require increased concentration. If, nevertheless, taking Drotaverine is necessary, then after it you should avoid activities that require increased attention and concentration for 2-3 hours.

Instructions for use:

Drotaverine is a synthetic drug that reduces the tone of smooth muscles of internal organs and helps reduce pain during spasms of various organs.

pharmachologic effect

Active ingredient: Drotaverine hydrochloride. Refers to antispasmodic drugs with myotropic action. Dilates blood vessels and reduces the tone of smooth muscles of the genitourinary and biliary system, organs of the gastrointestinal tract and intestinal motility. Improves oxygen supply to organs and tissues.

It has greater effectiveness and duration of action compared to papaverine, with which it is similar in pharmacological action and chemical structure. It is evenly distributed in tissues and has a vasodilating effect.

When administered orally, Drotaverine reaches maximum concentration within 45-60 minutes.

Release form

The drug is produced in the form of tablets, film-coated tablets and solution for injection.

Drotaverine tablets are round, beveled and scored, yellow-green in color. Each tablet contains 40 mg of active ingredient. Excipients: povidone (polyvinylpyrrolidone), potato starch, milk sugar, talc and magnesium stearate. 10 pieces in a blister, 1, 2, 3, 4 and 5 blisters in a cardboard box or 100 pieces in a polymer jar and cardboard box.

Drotaverine Forte tablets contain 80 mg of active ingredient. 10 pieces in a blister, 2 blisters in a cardboard box.

Injection. 1 ml of solution contains 20 mg of drotaverine hydrochloride. In ampoules of 2 ml, 5 ampoules in blister packs, 2 packs in a cardboard box.

Indications for use of Drotaverine

The use of Drotaverine is indicated to reduce pain and relieve spasms of smooth muscles of the gastrointestinal tract and urinary and biliary organs in case of:

• Pylorospasm;
• Peptic ulcer of the stomach and duodenum;
• Gastroduodenitis;
• Spastic constipation and renal colitis;
• Proctitis;
• Pielite;
• Tenesmach;
• Biliary or intestinal colic;
• Disorders of the biliary system and gallbladder of the hyperkinetic type;
• Cholecystitis;
• Postcholecystectomy syndrome.

In the treatment of spasms of the gastrointestinal tract, Drotaverine is used as part of combination therapy.

Also, according to the instructions, Drotaverine is effective:

• In gynecology for dysmenorrhea (painful periods), threatened miscarriage and premature birth, postpartum contractions;
• To relieve vascular spasms during tensor headaches;
• When carrying out some diagnostic manipulations and instrumental studies, cholecystography.

Contraindications

According to the instructions, Drotaverine is contraindicated in:

• Hypersensitivity to the components of the drug;
• Congenital lactose intolerance and lactase deficiency (due to the presence of lactose monohydrate in Drotaverine);
• Severe heart failure;
• Severe liver and kidney failure.

Drotaverine is not prescribed to children under 2 years of age and during lactation.

The drug should be used with caution in cases of low blood pressure, severe atherosclerosis of the coronary arteries, angle-closure glaucoma, prostatic hyperplasia, and during pregnancy.

Instructions for use of Drotaverine

Drotaverine tablets are taken orally, without crushing or chewing. The time of taking the drug does not depend on the time of meals. The duration of the course is determined individually in each case by the doctor.
The dose of the drug depends on age:

• From 2 to 6 years – 10-20 mg up to two times a day;
• From 6 to 12 years – 20 mg up to two times a day;
• Children over 12 years old and adults – 40-80 mg 2-3 times a day. Typically, the maximum daily dose should not exceed 240 mg.

Drotaverine hydrochloride injection solution is administered intramuscularly. The duration and dose are also calculated individually.

The usual dose for adults is 2-4 ml 1 to 3 times a day.

For hepatic or renal colic, slow intravenous administration is possible. To do this, 2-4 ml are pre-diluted with 0.9% sodium chloride solution.

In rare cases, in case of peripheral circulatory disorders, the drug is administered slowly intra-arterially.

Adolescents over 12 years of age are usually prescribed 1-2 ml of the drug 1-3 times a day.

During physiological childbirth, women are usually prescribed 2 ml of the drug intramuscularly at the beginning of the period of cervical dilatation. If necessary, re-introduce another 2 ml after 2 hours.

For stomach and duodenal ulcers, Drotaverine is prescribed in combination with other antiulcer drugs.

Side effects

Drotaverine is usually well tolerated. In rare cases, some side effects may develop:

• Vomiting or nausea;
• Fainting, disturbance of sleep and wakefulness, development of excessive sweating, headache;
• Arrhythmia, tachycardia, decreased blood pressure or feeling hot;
• Bronchospasm and slight swelling of the nasal mucosa;
• Itching, angioedema, skin rash, allergic dermatitis.

With intravenous administration of Drotaverine, a decrease in blood pressure and respiratory depression is sometimes observed.

Drotaverine enhances the effect of bendazole, papaverine and other antispasmodics, and also reduces the spasmogenic activity of morphine. When used simultaneously with levodopa, it weakens the effect of the latter. In combination with phenobarbital, the antispasmodic effect of Drotaverine increases.

There is no data on drug overdose.

Storage conditions

Drotaverine can be purchased without a doctor's prescription.

The shelf life of tablets is 3 years, solution for injections is 2 years.