Naphthyzin: instructions for use. Naphthyzin nasal drops - instructions, dosages, application features. How to get rid of “naphthyzine” addiction Naphthyzine side effects with long-term use

This drug is inexpensive and effectively relieves nasal congestion. But doctors do not recommend using Naphthyzin nasal drops for a long time.

Pharmacological properties, composition, price of the drug

Nasal drops have a vasoconstrictor and vasoconstrictor effect. The drug belongs to the group of alpha-adrenergic agonists, which affect alpha-adrenergic receptors of mucous tissue. Naphthyzin helps remove secretions from the nasal passage.

The main pharmacological properties include:

elimination of swelling of mucous tissues;
narrowing of the nasal vessels;
relief of nasal breathing with rhinitis;
reduction of inflammatory reactions;
dilation of the pupils of the eyes;
enhancement of local anesthetics.

The active ingredient of the drug is naphazoline. Additional components are boric acid and purified water.

The drug is available in 3 types:

solution in a dropper bottle;
spray solution;
Naphthyzin drops for eyes.

Naphazoline nitrate can be presented in the form of a 0.05% or 0.1% solution. There are children's and adults' Naphthyzin. The price of the drug depends on the manufacturer, concentration, and type of bottle. The cost of nasal drops is 33–70 rubles. Can be purchased at any pharmacy without a prescription.

Directions for use and dosage (for children and adults)

Naphthyzin is often used for instillation into the nose in the following cases:

acute rhinitis;
bleeding in the nasal cavity;
sinusitis;
swelling of the nasal mucosa;
laryngitis;
eustachitis;
inflammation of the nasal mucous tissue;
for rhinoscopy, as an auxiliary substance;
during operations performed on the nose;
after surgical interventions in the nasal cavity.

Naphthyzin is instilled into the eyes for allergic conjunctivitis and mechanical irritation.

It is better to discuss the use of Naphthyzin with your doctor. Naphazoline is addictive when used for a long time. A person who uses these nasal drops for a long time becomes dependent on them.

The use of Naphthyzin, contrary to what is written in the instructions, does not allow the mucous tissues of the nose to recover on their own, and the vessels dry out and atrophy under the influence of Naphthyzin. A person constantly experiences discomfort until he uses nasal drops.

Naphthyzin is used intranasally, 1-2 drops (or injections, if the drug is in the form of a spray) into each nasal passage 3-4 times a day.

If nasal congestion and swelling does not go away after taking Naphthyzin, it is recommended to consult a doctor. He will prescribe a similar remedy that will cause less harm to the nasal tissues. After this drug, you should take a break from treatment for 1–2 weeks.

Instructions for use of Naphthyzin prohibit its use by pregnant and lactating women. The vasoconstrictor drug affects not only the vessels of the nasal cavity, but also the uteroplacental circulation.

During pregnancy, a doctor can prescribe Naphthyzin only if the therapeutic effect of the drug outweighs the risks to the fetus.

Naphazoline can also cause a jump in blood pressure, which is why it is prohibited during lactation.

Advantages and disadvantages of the drug

Naphthyzin is considered one of the effective nasal decongestants.

Its advantages are as follows:

quickly relieves symptoms of swelling and makes breathing easier;
sold in pharmacies without a prescription;
low cost of the drug.

causes addiction and dependence;
does not eliminate the causes of the disease, but only alleviates the symptoms;
causes dryness in the nasal passages;
may be addictive if taken for more than 5–7 days;
increases blood pressure.

Contraindications for use

All medications have their contraindications for use.

age up to 1 year;
chronic rhinitis;
intolerance to naphazoline;
diabetes;
diseases of the endocrine system;
atherosclerosis;
arterial hypertension;
hyperthyroidism;
concurrent use of MAO inhibitors.

During pregnancy and lactation, Naphthyzin is used only after consultation with a doctor. In the 1st trimester, Naphthyzin drops are strictly prohibited.

If a person has difficulty breathing through the nose, it is better to consult a doctor to identify the cause. The specialist will tell you whether it is possible to drip Naphthyzin in a particular case.

Drops must be changed if the following side effects occur while taking the drug:

burning and itching in the nasal passages;
hyperemia;
headache;
increased heart rate;
redness of the mucous membranes.

Analogues of the drug

Before choosing an analogue of Naphthyzin, the doctor must determine the causes of nasal congestion. To change this drug, you must first consult your doctor.

In composition, similar substances are considered:

Naphazoline Ferein;
Sanorin;
Polynadim.

According to the mechanism of action (eliminate a runny nose, swelling, facilitate breathing), the following drugs can be called analogues:

Vicks Active;
ForNose;
Xylene;
Xymelin;
Nazivin;
Nazol;
Knoxprey;
Otrivin;
Rhinonorm;
Sanorin;
Tizin;
Lazolvan;
Espazolin.

Naphthyzin is considered one of the fast-acting remedies, but it should be used with caution. Overdose and long-term use can affect not only the condition of the mucous membranes, but also the body as a whole.

Useful video about why Naphthyzin should be used with caution

Naphthyzin belongs to the group of anticongestants and, in terms of its pharmacological action, is an alpha-adrenergic agonist.

The drug relieves swelling of the vessels of the mucous membranes of the nasal passages, reduces blood flow (and, consequently, hyperemia) to the venous sinuses and prevents exudation, which leads to significant relief of nasal breathing during a runny nose. The effect of naphthyzine is manifested by local application directly to the mucous membranes of the nose and develops within a few minutes after using the drug.

The duration of action of naphthyzine is several hours, depending on the severity of symptoms and the nature of the disease.

Clinical and pharmacological group

Alpha adrenergic agonist. When applied to the mucous membranes, it has a rapid, pronounced and long-lasting vasoconstrictor effect.

Conditions for dispensing from pharmacies

Dispensed without a doctor's prescription.

Prices

How much does Naphthyzin cost in pharmacies? The average price is 25 rubles.

Release form and composition

Naphthyzine is available in the following forms:

Nasal spray (10 ml in polyethylene or glass bottles, 1 bottle in a cardboard box).
Nasal drops (5, 10 or 15 ml in polyethylene or glass bottles, 1 bottle in a cardboard box);

Active ingredient: naphazoline nitrate – 0.5 mg or 1 mg in 1 ml of solution.

Auxiliary components: boric acid, purified water.

Pharmacological effect

Naphazoline promotes a pronounced narrowing of peripheral blood vessels, providing a calming effect on the nasal mucosa during rhinitis.

The effects of the medicine are quick and short-term. The patient begins to feel improvement a few minutes after using the drops. The action lasts for 4-5 hours. Long-term use of Naphthyzin can provoke the occurrence of drug-induced rhinitis and psychological dependence.

Indications for use

acute respiratory diseases;
manifestations;
acute nasopharyngitis;
inflammation of the mucous membrane in the postoperative period;
in cases of heavy bleeding from the nose.

Naphthyzine helps well with swelling of the larynx when it is caused by radiation or an allergic reaction. Sometimes the drug is prescribed for bacterial conjunctivitis of the eyes.

Is it possible to drip naphthyzine into the eyes?

Most people who abuse alcoholic beverages know that naphthyzin can be dropped into the eyes.

In this case, it is used to constrict the blood vessels of the eyes. Everyone knows that excessive alcohol consumption causes redness of the whites of the eyes. Naphthyzin also has vasoconstrictor properties. The blood vessels of the eyes narrow and the whites take on a normal appearance. The drops act very quickly and effectively.

However, there is one caveat - they are not intended for the eyes! Therefore, such use causes unpleasant symptoms: pain, pain in the eyes, and a feeling of dryness. For the most part, people who have used naphthyzine in this way at least once rarely resort to it again. Moreover, special preparations have been created for such purposes, for example.

Contraindications

There are some contraindications for use:

tachycardia;
diabetes mellitus;
simultaneous use of MAO inhibitors and 14 days after their use was completed;
severe eye diseases;
increased sensitivity to the components of the product;
hyperthyroidism;
arterial hypertension;
severe atherosclerosis;
age up to 1 year.

Use during pregnancy and lactation

The use of the drug is contraindicated during pregnancy and breastfeeding, since there is no data on the safety of using drops during this period.

The use of drops during pregnancy and breastfeeding may lead to systemic side effects.

Dosage and method of administration

The instructions for use indicate that in otorhinolaryngology Naphthyzin is used intranasally.

The dosage regimen is determined by age (in each nasal passage):

Adults and children over 15 years old: 3-4 times a day, 1-3 drops or 1 spray injection (0.05-0.1% solution);
Children 6-15 years old: 1-3 times a day, 2 drops or 1 spray injection (0.05% solution);
Children 1-6 years old (for drops) and 2-6 years old (for spray): 1-3 times a day, 1-2 drops or 1 spray of spray (0.05% solution).

For children, 0.05% Naphthyzin spray can be diluted with distilled water in a 1:1 ratio (up to 0.025%). The dosage regimen should not be changed.

The course of treatment for rhinitis should not exceed 5-7 days in adults, and 3 days in children.

For diagnostic purposes, the drug is used after cleaning the nose. In each nasal passage, drop 3-4 drops or make 1 injection, or insert a tampon soaked in a 0.05% solution of the drug for 1-2 minutes.

Side effects

Side effects of the drug include:

nausea and headache;
cardiopalmus;
inflammation of the mucous membrane and increased swelling;

With long-term use and increased doses:

chronic rhinitis;
mucosal atrophy;
loss of smell.

Side effects include rapid addiction. A patient who has systematically taken the drug feels a constant need to use it. This is due to the fact that after the medication wears off, the blood vessels begin to dilate again, causing noticeable nasal congestion.

Overdose

When the drug is abused and used in large doses, the patient develops signs of overdose, which are expressed in increased side effects described above, as well as weakness, dizziness, tachycardia, and increased blood pressure.

If such reactions develop, drug therapy should be stopped and consult a doctor for symptomatic treatment.

special instructions

Before you start using the drug, read the special instructions:

Naphazoline may have a resorptive effect.
With long-term use, the severity of the vasoconstrictor effect gradually decreases (the phenomenon of tachyphylaxis), and therefore it is recommended to take a break for several days after 5-7 days of use.

Drug interactions

When using the drug, it is necessary to take into account interactions with other medications:

Should not be used simultaneously with MAO inhibitors or within 14 days after stopping their use.
Naphazoline slows down the absorption of local anesthetics (prolongs their effect during superficial anesthesia).

one dropper tube contains:

active substance: naphazoline nitrate - 1 mg;

Excipients: boric acid, water for injection;

one bottle contains: active substance - naphazoline nitrate - 10 mg;

Excipients: boric acid, water for injection.

Pharmacotherapeutic group

Preparations for the treatment of diseases of the nasal cavity. Decongestants and other topical preparations for the treatment of the nasal cavity. Sympathomimetics. ATS code: R01AA08.

pharmachologic effect

Has a vasoconstrictor effect. The vasoconstrictor effect of local application appears within a few minutes and lasts for several hours. When applied to mucous membranes, it reduces swelling, hyperemia, and exudation, which helps ease nasal breathing during rhinitis. Naphazoline helps reduce swelling in the area of the excretory ducts of the paranasal sinuses and Eustachian tubes, improving the outflow of secretions. When applied to the nasal mucosa, it acts predominantly locally due to the narrowing of superficial blood vessels.

Indications for use

For short-term symptomatic treatment of acute rhinitis, as an adjuvant for inflammation of the paranasal sinuses, eustachitis, inflammation of the middle ear. To reduce swelling of the mucous membrane during diagnostic and therapeutic procedures.

Directions for use and doses

Intranasally.

One drop corresponds to 0.056 ml of naphthyzine (0.056 mg of naphazoline nitrate in one drop). Do not exceed 12 drops per day (0.7 mg naphazoline nitrate). Do not exceed the indicated doses. The drug should not be used for more than 5 days. Long-term use may cause headaches, insomnia, palpitations, and nausea. Dryness and irritation of the nasal mucosa may develop.

They are instilled into each nasal passage, throwing the head back a little and tilting it to the right when instilling into the left nostril and to the left when instilling into the right nostril.

For rhinitis, instill in adults - 1-3 drops of a 0.1% solution in each nasal passage.

The drug is used 2-3 times a day, but not more often than every 6 hours. Do not use for more than 1 week by adults. Can be reused only after 7-14 days.

During rhinoscopy, to prolong surface anesthesia, use 2-4 drops of a 0.1% solution with 1 ml of anesthetic.

Recommendations for using the tubedroppers: Before using the medicine, remove the protective cap from the dropper tube and cut off the membrane of the body neck with scissors without damaging the threaded part. Turn the body of the dropper tube with the medicine neck down and gently press on the body of the dropper tube, using it as a pipette. After using the dose recommended by the doctor or indicated in the instructions for use of the drug, turn the body of the dropper tube over with the threaded part up and screw on the protective cap.

Side effect

Local effect of the drug:

Sensation of burning and dryness in the nasal cavity, reactive hyperemia; with prolonged use - swelling of the mucous membrane.

When used for more than 1 week - swelling of the mucous membrane, atrophic rhinitis.

Systemic effect of the drug:

from the nervous system: weakness, tremor, nausea, headache, irritability;

from the cardiovascular system: in some cases, in predisposed patients - increased blood pressure, tachycardia, arrhythmia;

other: allergic reactions, extremely rarely - Quincke's edema.

If the above adverse reactions or adverse reactions not listed in these instructions for medical use of the drug occur, you should consult a doctor.

Contraindications

Increased individual sensitivity to the drug, angle-closure glaucoma, hypertension, tachycardia, severe forms of hypertension, severe atherosclerosis, diabetes mellitus, chronic rhinitis, hyperthyroidism, children under 15 years of age (for a 0.1% solution).

Overdose

Overdose is possible if the single doses and frequency of use specified in the instructions are not followed. Long-term or frequent use of the drug can cause intense swelling of the mucous membrane with nasal congestion after instillation, atrophic rhinitis. The risk of overdose increases in children (they are more prone to adverse reactions than adults). Cases of poisoning have been described after accidental ingestion or use of too large doses of naphazoline. A single toxic dose is 0.5 mg/10 kg body weight.

Symptoms: dizziness, increased blood pressure, bradycardia, headache, tremor, nervousness, increased sweating, palpitations, decreased body temperature, impaired consciousness. Rarely, cyanosis, nausea, cardiac arrest, pulmonary edema, mental disorders, and increased body temperature may occur. Depressant effect on the central nervous system - drowsiness, shock, apnea, coma. As an emergency first aid, you can take activated charcoal and call a doctor. Treatment: drug withdrawal, symptomatic therapy.

Precautionary measures

Naphthyzin is used at intervals of at least 3 hours. It is not recommended to use the drug for more than 5-7 days by adults. After this period, sensitivity to it may decrease, as a result of which its effectiveness decreases and there is a risk of developing drug-induced rhinitis. Therefore, after 5-7 days of use, you need to take a break for several days.

Use during pregnancy and lactation. Use is not recommended during pregnancy and breastfeeding due to the risk of accidental release of naphazoline nitrate into the systemic circulation. The use of naphthyzine during pregnancy and breastfeeding is possible only according to strict indications in cases where the expected therapeutic effect for the mother outweighs the potential risk of side effects in the fetus or

Impact on the ability to drive a car and potentially dangerous mechanisms: To date, there have been no reports of negative effects of the drug (used in standard therapeutic dosages) on the ability to drive vehicles and operate machinery.

Acute rhinitis, sinusitis, laryngitis, sinusitis, allergic, hay fever, eustachitis, severe nasal congestion. Here is a list of diseases for which the use of the drug is recommended. Nasal drops are also used for nosebleeds.

Before use, please read the list of contraindications. And also evaluate the expected benefits against the list of side effects.

Instructions for use of "Naphthyzin" for children

If you do not want to get poisoned, overdose or cause your baby to become addicted to Naphthyzin, strictly follow the instructions! Children over one year old should have nose drops 1-2 times a day, 1-2 drops of a 0.05% solution in each passage. For older children and adults, 2-3 drops 3-4 times a day. The use of the drug for longer than 7-9 days is strictly contraindicated.

Strictly follow the dosage when using children's "Naphthyzin", and also clean your nose before instillation. According to the principle - one more drop will not be superfluous, parents cause an overdose in their children. At the same time, according to recent studies, it has been revealed that in 37% of cases, the deterioration of the condition due to ODS is a consequence of the use of the drug

"Naphthyzin" - pros and cons

One of the “oldest” and first remedies for the common cold in our country, Naphthyzin, satisfied consumer demand for a long time, and no complaints were made against it. But what's happened lately? Why suddenly such negative recommendations?

Judging by the reviews of consumers, people who directly used this drug to relieve a runny nose, relieve swelling and start breathing, they claim almost the opposite effect of Naphthyzin after a week of use. In addition, the drug is addictive! That is, even when it would seem that the runny nose has long passed, the nose “requires” another drop of the drug to start breathing.

Children's "Naphthyzin" - is it worth the risk?

And don’t be fooled by the “children’s” label, it is no less dangerous than an adult. There is just a lower concentration of the medicinal substance. The main “yes” in favor of Naphthyzin is its ability to relieve swelling. Therefore, it is most often used specifically for acute rhinitis, and sometimes to relieve symptoms of sinusitis.

But this is where the beneficial properties of Naphthyzin end. And only side effects remain. Therefore, if you decide to use the drug to treat acute rhinitis or other nasal problems in your child, keep in mind that its use is strictly contraindicated if: the baby is not yet a year old; have problems with blood pressure; have heart problems; the child is diabetic; have problems with the eyes; during pregnancy or breastfeeding.

Naphthyzin nasal drops are one of the most famous and popular drugs for the treatment of a runny nose. The active substance of the drug is naphazoline, which belongs to α2 adrenergic agonists.

Available in the form of drops containing the active ingredient in concentrations of 0.05% and 0.1%. Depending on the manufacturer, it comes either in a glass bottle or a polyethylene dropper bottle with a volume of 10-15 ml.

Mechanism of influence and purpose

Naphthyzin drops are intended for instillation into the nose. Once on the mucous membrane of the nasopharynx, the active substance has a vascular effect, which leads to the elimination of swelling, redness, and hypersecretion of mucus.

Breathing through the nose is normalized, but when Naphthyzin drops are used for more than 5-7 days, addiction develops to them.

The therapeutic effect of the drug occurs within a maximum of 5 minutes and lasts from 4 to 6 hours.

For what diseases is the drug prescribed?

Naphthyzin drops are used for the following conditions:

In addition, the drug is instilled into the nose to facilitate examination of the nasal cavity and to prolong the therapeutic effect of local anesthetics.

Diseases for which medicine should not be used

Naphthyzin drops should not be instilled into the nose if the following pathologies are observed:

In addition, the drug at a dosage of 0.05% should not be dripped into the nose of infants, and Naphthyzin at a dosage of 0.1% should not be administered to children under 6 years of age.

Drops should be used with caution in patients suffering from angina, prostate adenoma and pheochromocytoma.

Undesirable effects developing during therapy and cases of overdose

Despite the fact that the drops are used intranasally, the active substance may have a resorptive effect, and as a result of use there is a risk of developing such adverse reactions as:

In case of an overdose of the drug, the development of a hypertensive crisis, bradycardia and a decrease in body temperature is possible. There is no specific antidote; therapy is aimed at eliminating the symptoms of intoxication.

Naphthyzin drops are instilled into the nose of patients over 15 years old, 1 to 3 drops of 0.05%-0.1% 3-4 times a day. The course of treatment should not exceed 1 week.

For children from 1 to 6 years old, 0.05% is prescribed 1-2 drops, and for children from 6 to 15 years old - 2 drops. Frequency of use is from 1 to 3 times a day. You can dilute a 0.05% solution of Naphthyzin with distilled water in a 1:1 ratio and instill it into the nose of children, depending on age, in the same dosages. The duration of therapy is no more than 3 days.

During rhinoscopy, Naphthyzin, in the form of 0.05%, instill 3-4 drops into each nostril or insert turundas moistened with the drug.

To prolong the effect of local anesthetics Naphthyzin, add 2 - 4 drops per 1 ml of anesthetic.

To stop nosebleeds, insert tampons soaked in a 0.05% solution of the drug.

Before using the drops, the nasal cavity must be cleared of mucus. Before dripping the drug into your nose, you need to slightly tilt your head back.

Prescriptions of the drug for pregnant and lactating women. The drug can be used by pregnant and lactating women only for health reasons, when the benefit of its use for them is higher than the risk for the child.

Pharmacological compatibility.

Naphazoline-based drugs and MAO inhibitors should not be used simultaneously. The interval between their administration should be at least 2 weeks, otherwise arterial hypertension may develop.

It is also unacceptable to prescribe drops with other vasoconstrictors, as this increases the frequency of adverse reactions from treatment.

You should not add a solution of the drug to prolong the action of local anesthetics, which increase the sensitivity of the heart muscle to indirect adrenergic agonists.

Terms of sale and dispensing from the pharmacy. The medicine is available without a specialist prescription. Store it at a temperature of 10-25 degrees, out of the reach of children and protected from direct sunlight.

What can replace the medicine?

The pharmaceutical industry produces a complete analogue of the drug Naphthyzin - Sanorin.

In addition, there are drugs on the market with similar mechanisms of action, such as:

Before changing the drug, you should consult a specialist.

Precautionary measures. The drug does not slow down the reaction rate and does not affect the ability to drive a car.