Staphylococcal phage instructions. Staphylococcal bacteriophage - a real alternative to antibiotics or a drug with questionable effectiveness? Evacuation of Bacteriophage populations from the cell

The active component of the drug Staphylococcal Bacteriophage is antistaphylococcal bacteriophage in liquid, suppository, ointment or tablet form.

Release form

• 50 or 100 ml of such a solution in a bottle - one bottle in a cardboard box.
• 20 ml of this solution in a bottle - four bottles in a cardboard box.
• 25 ml of such a solution in an aerosol package - one package in a cardboard box.
• 10 and 20 grams of ointment in a bottle, one bottle in a cardboard box.
• 10 candles per package, one package in a cardboard box.
• 10, 25 and 50 tablets per package, one package in a cardboard box.

pharmachologic effect

Antibacterial action.

Pharmacodynamics and pharmacokinetics

What is a Bacteriophage?

This drug is relatively new on the drug market and many patients have a natural question: “Bacteriophage - what is it?”

Bacteriophages are viral particles that kill only certain types of pathogenic bacteria. On their basis, appropriate drugs are created. The discovery of the drugs belongs to the Canadian scientist Felix D'Herelle.

Structure of Bacteriophages

An ordinary bacteriophage consists of a tail and a head. The tail is usually 3-4 times longer than the diameter of the head. The head contains double-stranded or single-stranded RNA or DNA with inactive transcriptase surrounded by a shell of protein or lipoprotein called capsid .

Reproduction of Bacteriophages

As with conventional viruses, the reproduction cycle of lytic bacteriophages can be divided into adsorption of the phage on the cell wall, introduction of DNA, reproduction of the phage, and evacuation of daughter populations from the cell.

Attachment of the phage to the bacterial cell occurs due to its surface structures, which serve as specific receptors for viruses. In addition to receptors, phage attachment depends on temperature, acidity of the environment, the presence of cations and a number of other compounds. Up to 300 virus particles can be adsorbed on one cell.

After attachment, the cell wall splits lysozyme. At the same time, calcium ions are released, activating ATPase - this causes contraction of the sheath and insertion of the tail shaft into the cell. The viral DNA is then injected into the cytoplasm. Having penetrated the bacterium, the phage DNA takes control of the cell’s genetic apparatus, carrying out the phage’s reproductive cycle.

First of all, the synthesis of enzymes necessary for the formation of copies of phage DNA occurs ( DNA polymerases, thymidylate synthetase, kinases ). It takes 5-7 minutes from the moment of infection. RNA polymerase cells converts viral DNA into mitochondrial RNA, which is translated by ribosomes into “early” proteins. “Early” proteins are mainly viral RNA polymerase and proteins that limit bacterial gene expression. The viral RNA polymerase transcribes the so-called “late” proteins necessary for the assembly of new phage particles.

The reproduction of nucleic acids occurs due to the activity synthesized DNA polymerases virus. By the end of the cycle, the components of the phage are combined into a mature virion.

Evacuation of Bacteriophage populations from the cell

Newly biosynthesized proteins in the cytoplasm form a pool of precursors. The other pool includes the DNA of the offspring. Specialized regions in the viral DNA induce the association of these proteins around groups of nucleic acid molecules and the synthesis of new heads. The head interacts with the tail to form a daughter phage. After the offspring are released, the host cell is destroyed, releasing a new population.

An alternative to cell destruction may be an integrative form of interaction in which the phage DNA, instead of replicating, is integrated into the bacterial chromosome or becomes plasmid . As a result, the viral genome replicates along with the host DNA.

Types of Bacteriophages

The use of bacteriophages determines their clinical classification. Based on this thesis, the following types of bacteriophages can be distinguished:

• bacteriophages for therapy intestinal infections : dysentery, polyvalent, salmonella ABCDE-group, typhoid, coliproteus, intesti-bacteriophage (a mixture of phages against the most common pathogens of intestinal infections);
• bacteriophages for therapy purulent-septic lesions : Klebsiella pneumoniae, Klebsiella polyvalent, Pseudomonas aeruginosa, antistaphylococcal bacteriophage, coli, Proteus, streptococcal, combined pyobacteriophage (a mixture of phages that destroy most likely pathogens of infections of a purulent-septic nature).

The use of bacteriophage preparations in medicine is becoming increasingly widespread due to the increasing incidence of polyvalent resistance of pathogens to antibacterial agents.

Indications for use

How to take this medicine? The drug is used for the treatment and prevention of diseases caused by staphylococcus:

• urogenital infections ( , salpingoophoritis, );
• infections in surgery (burns, wound suppuration, , boils, phlegmon, felon, paraproctitis, );
• diseases of the throat, ear, nose, respiratory organs (, sinuses, , pleurisy );
• digestive tract infections ( gastroenterocolitis ), , ;
• prevention of postoperative septic complications;
• prevention of hospital infections.

Contraindications

There are no contraindications to the use of this product.

Side effects

Adverse reactions to the administration of the drug have not been established.

With the intradermal route of administration, short-term hyperemia and inflammation.

Instructions for staphylococcal bacteriophage (Method and dosage)

The drug is injected into the site of infection. The frequency of injections and their size are determined by determining the clinical form of the disease, the nature of the infectious focus and standard recommendations. The average duration of treatment is 5-15 days. In cases of relapse, additional courses of treatment are possible. Instructions for using staphylococcal bacteriophage for children and adults are somewhat different. Recommendations for the use of the drug for children are given at the end of the section.

Liquid phage is allowed to be used topically in the form of lotions, irrigation or tamponing in a volume of up to 200 ml, taking into account the size of the affected area. An ointment is also available for topical use.

Therapy purulent-inflammatory limited lesions It is advisable to carry out both locally and orally for 1-4 weeks.

At purulent-inflammatory lesions of the throat, ear or nose the drug is used for rinsing, instilling, washing and administering moistened turundas 2-10 ml up to three times a day.

At carbuncles And boils liquid bacteriophage is injected directly into the lesion or around it, 0.5-2 ml daily. In total, up to 5 injections are given per course of treatment.

Treatment chronic osteomyelitis carried out by infusing the drug into the wound immediately after surgical treatment.

At abscesses The bacteriophage is injected into the cavity of the lesion, emptied of pus. When opening an abscess, a tampon moistened with the drug is inserted into the wound.

Treatment of deep pyodermatitis carry out intradermal injections of the product into one place, 0.1-0.5 ml, or into several places in a total dose of up to 2 ml. Administration is carried out every 24 hours, a total of 10 injections.

For an introduction to abdominal, pleural, articular cavities use capillary drainage and inject up to 100 ml of bacteriophage every other day. There are only 3-4 such introductions.

At cystitis the drug is injected into the bladder using a catheter.

At purulent bursitis, pleurisy or arthritis the drug is administered into the cavity, previously emptied of pus, 20 ml every other day. The course of treatment is 3-4 administrations.

Staphylococcal bacteriophage is also used orally in the form of tablets in the treatment of urogenital infections ( cystitis, pyelonephritis, pyelitis, salpingoophoritis, endometritis ), intestinal infections and other diseases caused by staphylococcus.

How to use Staphylococcal Bacteriophage for intestinal staphylococcal lesions And intestinal dysbiosis : the drug is used orally on an empty stomach three times a day 2 hours before meals; The drug is prescribed rectally in the form of suppositories or enemas once a day. Treatment lasts 7-10 days.

For newborn children, the drug is diluted with an equal amount of water in the first 2 doses. It can also be mixed with breast milk.

At sepsis or enterocolitis In newborns, the drug is used by performing high enemas up to three times a day. A combination of rectal and oral use is permitted.

During pregnancy and lactation

It is possible to use the product during the specified periods under the supervision of the attending physician.

Compound

Active substance: 1 bottle (20 ml) or 1 bottle (100 ml) contains a sterile bacteriophage solution that lyses microorganisms of the type Staphylococcus aureus, with an activity of at least 10 5;

Excipients: quinosol 0.0001 g/ml.

Dosage form

Liquid oral, oromucosal, cutaneous, rectal, vaginal.

Basic physical and chemical properties: transparent yellow liquid of varying intensity.

Pharmacological group. ATX code. Other antibacterial agents. J01XX.

Immunological and biological properties

Pharmacological. The drug is a sterile filtrate of phagolysate of pathogenic strains S. aureus. Has the property of directly selectively acting on strains S. aureus of various origins and cause their lysis.

Pharmacokinetics. We haven't studied it.

Indications

Used by adults and children for complex treatment and prevention of infectious diseases caused by strains S. aureus of various origins.

For treatment as adjunctive therapy:

• diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy)
• surgical infections (wound suppuration, burns, abscesses, phlegmon, boils, carbuncles, hidradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis)
• urogenital infections (urethritis, cystitis, pyelonephritis, endometritis, salpingoophoritis, colpitis)
• gastrointestinal infections (gastroenterocolitis), cholecystitis, intestinal dysbiosis.

For prevention:

• postoperative infectious complications (treatment of postoperative wounds)
• nosocomial infections (according to epidemic indications).

Contraindications

Hypersensitivity to the components of the drug.

Interaction with other drugs

The drug is used in combination with other antibacterial agents, as well as as monotherapy - if the patient is intolerant to antibiotic therapy and the strains of the causative agent are resistant to antibiotics.

Features of application

Before using the drug, the sensitivity of the pathogen to the staphylococcal bacteriophage should be determined.

1. Treatment with bacteriophage should be started as early as possible. 2. Before use, the drug must be shaken.

3. A cloudy solution cannot be used.

4. If chemical antiseptics were used to treat the wound with the bacteriophage, the wound must be thoroughly washed with a sterile 0.9% sodium chloride solution.

5. Since the drug contains a nutrient medium in which bacteria from the environment can develop, when opening the bottle, selecting and storing the drug, the following rules must be observed:

• hands should be washed thoroughly;
• Before removing the cap, it should be treated with a solution containing alcohol
• the cap should be removed without removing the stopper;
• the drug should be taken from an open bottle with a sterile syringe (by piercing the stopper); when using small doses of the drug, it is necessary to use a sterile syringe with a needle for each selection of the drug;
• If, when opening the bottle along with the cap, the stopper was removed, it should not be placed on the table with the inner surface; the bottle should not be left open; it should be closed with a stopper after taking the drug
• The bottle is closed with a stopper and should be stored in the refrigerator!

6. Subject to the above rules and storage conditions, in the absence of turbidity, the shelf life after opening the bottle is 24 hours.

7. Since the drug is stored in the refrigerator, the drug must be brought to room temperature before use.

8. When rinsing the mouth and throat, the bacteriophage foams a lot, so you need to put it into your mouth in small doses.

9. When using small doses of the drug for instillation into the nose (2-8 drops), the drug can be instilled using a cleanly washed pipette, but without immersing it in a common bottle; the amount of the drug required for use can be poured into another clean container.

Use during pregnancy or breastfeeding. Not researched.

The ability to influence the reaction rate when driving vehicles or other mechanisms. Does not affect.

Directions for use and doses

The drug is used as prescribed by a doctor. The duration of treatment, dose and regimen of use is determined by the doctor. Before using the drug, it is advisable to conduct a preliminary laboratory test indicating the causative agent of the disease and data on its sensitivity to staphylococcal bacteriophage.

Considering the location of the source of infection, the drug can be used:

• locally - in the form of irrigation, washing, rinsing, infusion, instillation, lotions, applications, tampons, turundas;
• by oral administration (per os)
• by insertion into the rectum (per rectum) in an enema.

When treating purulent-inflammatory diseases with localized lesions, it is advisable to use the drug simultaneously both externally and internally for 7-20 days.

Doses of the drug are determined by the nature of the source of infection and are:

• up to 200 ml (taking into account the size of the affected area) - for irrigation, lotions, tampons;
• 10-20 ml - for infusion into the wound for osteomyelitis (after appropriate surgical treatment)
• for abscesses, the drug is injected into the cavity of the lesion after removing pus from it using a puncture; in this case, the amount of the administered drug should be slightly less than the volume of removed pus
• 5-10 ml for irrigation or tamponing of the vaginal and uterine cavities for purulent-inflammatory gynecological diseases; tampon once a day (tampons are left on for 2:00)
• 10 ml - for irrigation or tamponing for colpitis; tamponed 2 times a day (tampons are left on for 2:00)
• 2-10 ml - for irrigation, rinsing, washing, instillation, wetting of the turunda for purulent-inflammatory diseases of the ear, throat, nose, the procedure is carried out 1-3 times a day (the turunda is left for 1:00). For children under 11 years of age, it is advisable to treat the tonsils with a syringe (or bulb) and instill the drug into the nose; to treat the back of the throat, older children can gargle and instill a small amount (2-8 drops) of the drug into the nose.

for oral administration (per os) and enema (per rectum)

• for cystitis, pyelonephritis, urethritis, the drug is taken orally - 3 times a day (1:00 before meals).

Children. Suitable for children aged 7 years and older.

Content

After studying the instructions for use, you will learn how to use staphylococcal Bacteriophage for Staphylococcus aureus in an adult or child, as well as its price, indications and side effects. The medicine is an immunobiological preparation, the composition of which is based on specific viruses. They infect microorganisms that are sensitive to them. This remedy is used only in the presence of an infection caused by bacteria of the genus Staphylococcus (staphylococcus). The medicine is new, but has already proven itself to be an effective drug with good reviews.

What is staphylococcal bacteriophage

This is the name for a biological product containing beneficial viruses that have a detrimental effect on pathogenic bacterial cells. The peculiarity of the product is that it is effective only against one pathogen. This distinguishes them from antibiotics. Staphylococcal bacteriophage lives from a strain of staphylococci, which are the causative agent of purulent diseases. The drug is often prescribed to treat infections of the skin and mucous membranes of the visceral organs.

Compound

The active ingredient of the drug is anti-staphylococcal bacteriophage. This is a viral particle that kills pathogens. It consists of a head and a tail, which is 3-4 times its diameter. The main substance can be presented in liquid form, in the form of tablets, ointments or suppositories. An additional component is quinosol.

pharmachologic effect

Staphylococcal bacteriophage has antibacterial activity against staphylococcal cells. Viral particles attack pathogenic microorganisms and release their DNA and RNA inside due to the preliminary dissolution of the shell. The main substance practically does not penetrate into the systemic circulation. It is localized only at the site of inflammation, because it exists only under the condition of a staphylococcal infection. After the destruction of pathogenic viruses, the number of bacteriophage particles gradually decreases, and then it is eliminated from the body tissues.

Release form

The main form of release is a solution. It is packaged in 50 or 100 ml bottles in one box and 20 ml bottles in sets of 4, as shown in the photo. Other forms of release of the drug:

• tablets of 10, 25 or 50 pieces, packaged in cardboard packages;
• aerosol with a volume of 25 ml;
• ointment in bottles of 10 or 20 g;
• rectal suppositories, packed in 10 pieces.

Indications for use

Staphylococcal bacteriophage is used for all acute and chronic diseases caused by staphylococcus. This drug is indicated for the treatment of intestinal dysbiosis, cholecystitis, gastroenterocolitis. These are diseases of the digestive tract. In addition to intestinal infections, many other pathologies or cases are also indicated for use:

• surgical infections - boils, felons, abscesses, arthritis, bursitis, osteomyelitis, burns, purulent wounds, mastitis, hidradenitis, carbuncles;
• diseases of the ENT organs - inflammation of the sinuses or middle ear, runny nose, sinusitis, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy;
• urogenital infections - urethritis, colpitis, cystitis, endometritis, pyelonephritis;
• prevention of nosocomial infections and prevention of sepsis after surgery.

Advantages of staphylococcal bacteriophage over antibiotics

The bacteriophage has an antibacterial effect. Antibiotic drugs also have it. Medicines differ from each other in several ways. Judging by the reviews, the bacteriophage has undeniable advantages that allow you to make a choice in favor of it rather than antibiotics. These advantages are the following:

• does not suppress human immunity;
• does not lead to the development of phage-resistant cultures;
• do not destroy beneficial bacterial microflora;
• do not lead to addiction;
• have no contraindications;
• effective against microorganisms that are insensitive to antibiotics;
• can be used with all other medications, including antibiotics;
• can be prescribed for the purpose of prevention;
• allowed for people of any age, even infants;
• not prohibited for pregnant and lactating women;
• has an immunomodulatory effect.

Instructions for use of Staphylococcal Bacteriophage

Before prescribing, the sensitivity of the pathogen to the bacteriophage is checked. The drug itself is injected into the lesion after removal of the purulent contents. The dose and frequency of use are determined taking into account the disease and age of the patient. The average duration of treatment is 5-15 days. Additional therapy is prescribed for relapses. Depending on the form of release, the medicine is used orally, rectally, in the form of injections, irrigations or applications. The bacteriophage is injected into the uterus or vagina, nasal sinuses or drainage cavities.

Liquid Bacteriophage

This form of Bacteriophage release is used topically for irrigation, tamponing or lotions. Taking into account the nature of the purulent focus of infection, the doctor determines the treatment regimen:

1. For purulent-inflammatory diseases of the ENT organs, 2-10 ml is indicated up to 3 times a day. The medicine can be administered using turundas into the nasal passages for 1 hour. The same dosage is used for rinsing, rinsing and inhaling the throat.
2. For pyelonephritis, urethritis, cystitis, the solution is administered through a cytostomy or nephrostomy up to 2 times a day. Dosage for the bladder cavity is 20-50 ml, for the renal pelvis – 5-7 ml.
3. For purulent infections of the uterus or vagina. In this case, it is indicated to take the liquid form of the drug orally, 5-10 ml once a day. To treat colpitis, a tampon is inserted into the vagina for 2 hours, which is generously moistened with bacteriophage, or irrigated with 10 ml of solution.
4. To treat boils, liquid bacteriophage is injected directly into or around the site of inflammation, 0.5-2 ml. The course of treatment is 2-3 administrations.
5. In case of chronic osteomyelitis, after surgical treatment, liquid staphylococcal bacteriophage is poured into the wound in an amount of 10-20 ml.
6. For administration into the joint cavities, a dosage of up to 100 ml is used. Then, for several more days, the bacteriophage is reintroduced through capillary drainage.

In tablets

Staphylococcal bacteriophage in tablets is used less frequently, because the bioavailability of this form of release is significantly lower compared to the solution. When treating urogenital infections caused by staphylococcus, 3 tablets are prescribed daily an hour before meals. Dosage regimens for other diseases:

1. For the treatment of purulent-inflammatory diseases with localized lesions, tablets are taken orally 2-3 times a day 1 hour before meals. The course of treatment is 7-20 days, taking into account the clinical situation.
2. For dysbacteriosis. Tablets are taken daily 1-3 times an hour before meals. To increase the effectiveness of treatment for dysbiosis, a combination of rectal administration in the form of enemas after bowel movements is recommended.

Instructions for use for children

For a newborn baby, the drug is diluted with water in a 1:1 ratio. This condition is met in the first two applications. It is allowed to mix the solution with breast milk. For other diseases, the child’s treatment regimen is as follows:

1. Pyoderma, purulent inflammation, omphalitis. Newborns are advised to apply twice a day to the affected surface. To do this, 5-20 g of ointment is applied to gauze or bandage and applied to the desired location. Additionally, 1 tablet can be prescribed up to 4 times a day.
2. Ear inflammation. You need to drip 2-3 drops of the solution into each ear canal. For children under 3 years old, cotton wool moistened with the drug is inserted into the ears.
3. Enterocolitis, sepsis in newborns. Treatment is high enemas 2-3 times a day with a dosage of 5-10 ml of solution. The course of treatment is 5-15 days.

How to gargle

Do not mix the bacteriophage solution with other liquids. It is correct to gargle with undiluted medication. To prevent staphylococcus from getting inside, you need to pierce the plug with a disposable sterile syringe. Next, the needle is removed from it, after which they immediately begin gargling or instilling nose drops. It is not recommended to pour the solution into non-sterile containers.

Bacteriophage during pregnancy and lactation

The absence of serious contraindications and side effects made it possible to use Antistaphylococcal Bacteriophage in the treatment of infections in pregnant women. An important condition is that therapy should be prescribed only by a doctor and carried out under his supervision. In addition, this type of bacteriophage is also prescribed only if the expectant mother has an infection caused by staphylococci.

Drug interactions

Staphylococcal bacteriophage can be used together with other drugs, including antibiotics. If the drug is used locally after using antiseptic solutions, excluding Furacilin, then it is recommended to first rinse the affected area with a 3% solution of sodium bicarbonate or saline.

Side effects and overdose

During the study of the drug, no side effects from its use were identified. Judging by the reviews, they are observed only with intradermal administration. Inflammation and hyperemia may occur here, but they are short-lived. Symptoms in case of an overdose of Bacteriophage have also not been studied, therefore they are also not described in the instructions for use of the drug.

Contraindications

Staphylococcal bacteriophage is distinguished by the fact that it has no serious contraindications. The only case when it cannot be used is individual intolerance or hypersensitivity to the active components of the drug. The medicine is allowed even for children and pregnant women, but subject to the exact dosage and dosage regimen.

Analogues

The staphylococcal bacteriophage has a number of drugs that are similar to it in the principle of action, i.e. also having an antibacterial effect against certain pathogenic microorganisms. Such means include:

• Monural;
• Kubitsin;
• Fosmicin;
• Kirin;
• 5-Nok;
• Trobitsin;
• Fortreaz;
• Dioxidine;
• Nitroxoline.

Instructions for medical use

medicine

STAPHYLOCOCCAL BACTERIOPHAGE LIQUID

Tradename

Staphylococcal bacteriophage liquid

International nonproprietary name

Dosage form

Sterile liquid in 20 ml bottles for oral, local and external use.

Compound

1 ml of the drug contains

active substance- a mixture of sterile filtrates of phagolysates of bacteria Staphylococcus aureus - phage titer of at least 1x10 6,

excipient- 5% sterile solution of quinosol - 0.01% of the volume of liquid phage.

Description

A transparent yellow liquid of varying intensity with a specific taste.

Pharmacotherapeutic group

Other antibacterial drugs.

ATC code J 01 X

Pharmacological properties

Staphylococcal bacteriophage is an immunobiological preparation, phage. The drug is a phagolysate filtrate, active against staphylococcal bacteria of the most common phagotypes, incl. Staphylococcus aureus. Regardless of the method of administration, the drug penetrates the blood and lymph and enters the site of inflammation. The main part of the drug is excreted by the kidneys, providing a sanitizing effect on the urinary tract, and the rest through the gastrointestinal tract.

A bacteriophage is a specific bacterial virus that is adsorbed on the cell membrane of a homologous bacterium, penetrates the cell and lyses it.

Liquid Staphylococcal Bacteriophage contains selective, only virulent bacterial phages that have the ability to lyse Staphylococcus aureus, isolated for purulent infections, which ensures high activity and effectiveness of the drug.

Indications for use

The drug is used for the treatment and prevention of bacterial purulent-inflammatory diseases caused by Staphylococcus aureus in all age and high-risk groups

Treatment

Surgical infections: purulent wound, burn, abscess, phlegmon, boil, carbuncle, hidradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis

Urogenital infections: urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis

Gastroenterological diseases: enterocolitis, cholecystitis, irritable bowel syndrome (IBS) (dysbiosis)

Bacterial infections of the upper and lower respiratory tract: inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy

Prevention

Treating fresh wounds

Purulent complications during surgical manipulations and operations

Bacterial complications in acute respiratory viral diseases

Sepsis and enterocolitis in newborns with intrauterine infection

Bacterial contamination and nosocomial infections in medical institutions

Directions for use and doses

The drug is used in combination with other antibacterial agents, as well as as monotherapy - when the patient is intolerant to antibiotic therapy and when strains of the causative agent are antibiotic-resistant. Before using the drug, it is advisable to determine the sensitivity of the pathogen to the staphylococcal bacteriophage. The drug is especially effective in the initial stage of the disease and when applied directly to the lesion.

Taking into account the localization of the source of infection, the liquid Staphylococcal Bacteriophage drug can be used:

locally - in the form of irrigation, washing, rinsing, infusions, instillations, applications, tampons, turundas;

by introduction into cavities (abdominal, pleural, articular, bladder) through capillary drainage, catheter;

by oral administration (per os);

by insertion into the rectum (per rectum) using an enema.

For the treatment of purulent-inflammatory diseases with local lesions, liquid Staphylococcal Bacteriophage is prescribed both locally and for oral administration (per os). The duration of treatment with the drug is from 5 to 10 days.

Doses of the drug are determined by the nature of the source of infection and are:

up to 200 ml (taking into account the size of the affected area) - for irrigation, lotions, tampons;

up to 100 ml - for introduction into cavities (pleural, articular, other limited cavities), injected through capillary drainage, then the cavity is tightly sutured or capillary drainage is left, through which the bacteriophage is reintroduced over several days. For purulent pleurisy, bursitis or arthritis, the bacteriophage is injected into the cavity (after removing the pus) in an amount of up to 200 ml or more, every other day, only 3-4 times.

10-20 ml - for infusion into the wound for osteomyelitis (after appropriate surgical treatment).

For abscesses, the drug is injected into the cavity of the lesion after removing pus from it using a puncture; in this case, the amount of the administered drug should be slightly less than the volume of pus removed; pus can be removed by opening the abscess and then inserting a tampon, abundantly moistened with bacteriophage, into the cavity. In the following days, the drug is injected into the infected cavity using drainage. The procedure is carried out once a day, for 3-5 days.

5-10 - ml for irrigation or tamponing of the cavities of the vagina and uterus for purulent-inflammatory gynecological diseases; tampon once a day (tampons are left for 2 hours);

10 ml - for irrigation or tamponing for colpitis; tampon 2 times a day (tampons are left for 2 hours);

2-10 ml - for irrigation, rinsing, washing, instillation, wetting of the turunda for purulent-inflammatory diseases of the ear, throat, nose, the procedure is carried out 1-3 times a day (the turunda is left for 1 hour). For children under the age of 11 years, it is advisable to treat the tonsils with a syringe (or bulb) and instill the drug into the nose - to treat the back surface of the pharynx; Older children can gargle and instill a small amount (2 ml) of the drug into the nose.

For cystitis, pyelonephritis, urethritis, the bacteriophage is injected into the bladder through a catheter (or through a cystostomy) or into the renal pelvis through a nephrostomy and the drug is also taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is injected 2 times a day, 20-30 ml into the bladder and 5-10 ml into the renal pelvis.

In the treatment of stomatitis and chronic periodontitis, the drug is used in the form of rinses in the mouth 3-4 times a day in a dose of 10-20 ml, and turunda impregnated with Staphylococcal bacteriophage is injected into the periodontal pockets for 5-10 minutes.

For intestinal diseases, IBS (dysbacteriosis), liquid Staphylococcal Bacteriophage is used orally and in the form of enemas. The drug is taken on an empty stomach, 1 hour before meals. In the form of enemas, it is prescribed once a day, in the evening, before bedtime, after bowel movements.

Prevention

The dose and course of prescription of a drug for prophylactic use is determined by the condition of the patients.

Staphylococcal bacteriophage is used for prophylaxis in an amount of 50 ml for irrigation of postoperative wounds and treatment of fresh wounds.

In order to prevent sepsis and enterocolitis in newborns with intrauterine infection or the risk of nosocomial infection, staphylococcal bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

Staphylococcal bacteriophage can be used for prophylactic purposes in the form of irrigation of the skin and mucous membranes for burns, purulent-inflammatory diseases, infected wounds, and sore throat.

If chemical antiseptics other than furatsilin were used before topical application of the staphylococcal bacteriophage, the wound should be washed with physiological sodium chloride solution or 2-3% soda solution (sodium bicarbonate).

Side effects

Bacteriophage preparations are non-toxic. Undesirable effects and reactions associated with the use of Staphylococcal bacteriophage were not noted.

Contraindications

Hypersensitivity to any component of the drug

Drug interactions

Drug interactions between bacteriophage drugs have not been described.

Bacteriophage preparations can be used with other drugs, including antibacterial drugs.

special instructions
Treatment with bacteriophage should be started as early as possible.

The drug must be shaken before use. A cloudy preparation cannot be used.

If chemical antiseptics were used to treat the wound before using the bacteriophage, the wound must be thoroughly washed with a sterile 0.9% sodium chloride solution.

Since the drug contains a nutrient medium in which bacteria from the environment can develop, the following rules must be observed when opening the bottle, selecting and storing the drug:

Hands should be washed thoroughly;

Before removing the cap from the bottle, it should be treated with a solution containing alcohol;

The cap should be removed without removing the stopper;

The drug should be taken from an opened bottle with a sterile syringe (by piercing the stopper);

If, when opening the bottle along with the cap, the stopper was removed, you should not place it on the table with the inner surface; the bottle should not be left open; it should be closed with a stopper after taking the drug;

The opened bottle must be stored in the refrigerator. The contents of the bottle can be used within 24 hours after opening, when stored under appropriate conditions.

Use in pediatrics

Bacteriophage preparations can be used during

Pregnancy and lactation

Bacteriophage preparations can be used during pregnancy and lactation.

Features of the effect of the drug on the ability to drive a vehicle and potentially dangerous mechanisms

Bacteriophage preparations do not affect the ability to drive a car or perform work that requires increased concentration and motor response.

Overdose

Symptoms of an overdose of bacteriophage drugs are unknown.

Release form and packaging

Bottles of 20 ml made of medical glass, in a cardboard box there are 4 bottles of the drug along with instructions for medical use in the state and Russian languages.

Storage and transportation conditions:

Store at temperatures from 2 o C to 15 o C.

Keep out of the reach of children!
Bacteriophage preparations should not be used in case of turbidity.

Shelf life

Do not use after the expiration date indicated on the package.

Conditions for dispensing from pharmacies

Over the counter

Manufacturer

JSC Biochimpharm, Georgia

Address: st. L. Gotua 3, Tbilisi 0160, Georgia,

The word is formed from two: bacterium (microbe, microorganism) and phagos (eating). So, bacteriophages are “microbe eaters”. Phagocytes are also present in the human body, forming part of the human immune system. The phage recognizes the desired bacterium and acts destructively on its wall, often settling inside it. In this article we will look at bacteriophages and the reviews available about them.

“Staphylococcal bacteriophage” - what is it?

This is a virus (eater) that specifically destroys pathogens of staphylococcal infections, such as:

• staphylococcus auratilis (Staphylococcus aureus);
• staphylococcus pneumoniae (causative agent of pneumonia);
• staphylococcus epidermiale (causing infections of the skin and soft tissues), etc.

Instructions for use of "Staphylococcal bacteriophage"

“Staphylococcal Bacteriophage” collects only positive reviews. Let's take a closer look at the instructions for it.

Dosage form - solution for external and internal use.

Release form: 100, 50, and 20 ml in glass bottles, packed in a cardboard box of 1, 4, 10 pcs.

Ingredients: filtered lysate of pathogenic strains of staphylococcus, preservative quinone.

Description: colorless transparent or slightly colored liquid without sediment. It is an immunobiological drug.

This is confirmed by numerous reviews. “Staphylococcal bacteriophage” has the following effect on microbes and the human body. The phagocytes contained in the solution have the ability to differentiate bacteria and select microorganisms sensitive to the bacteriophage, causing their destruction, and multiply, generating new similar cells. Phagocytes do not have a destructive effect on the cells of the human body and do not cause them harm.

Areas of application

The instructions for use for the drug “Staphylococcal bacteriophage” indicate that it is used for diseases caused by staphylococcal infection:

1. Ophthalmology: conjunctivitis, blepharitis.
2. Otorhinolaryngology: otitis (inflammation of the outer, middle or inner ear), tonsillitis (inflammation of the tonsils), laryngitis (inflammation of the larynx), pharyngitis (inflammation of the throat), rhinitis (inflammation of the nasal mucosa).
3. Pulmonology: diseases of the respiratory tract (tracheitis, bronchitis, pneumonia).
4. Gynecology: vaginitis, inflammation of the cervix, uterine mucosa.
5. Urology: pyelonephritis, cystitis, urethritis.
6. Surgery: treatment of infected wounds, abscesses, inflammatory processes in the joints (arthritis, bursitis), stoma care, bacterial infections of the skin and soft tissues (furunculosis, carbunculosis, mastitis, hidradenitis, proctitis, paraproctitis).
7. Burn surgery: treatment of poorly healing infected burns.
8. Diseases of the gastrointestinal tract: gastritis, enterocolitis, colitis, cholecystitis, dysbacteriosis (prevention and treatment).

This drug is also used to treat inflammatory processes in the body of newborns, generalized staphylococcal infection (sepsis), to prevent nosocomial infections, to prevent acute respiratory and viral infections caused by staphylococcus (to increase local immunity).

It is important to remember that staphylococcal bacteriophage destroys only the causative agents of staphylococcal infections.

Directions for use and required dosage

The instructions for use for the drug “Staphylococcal bacteriophage” indicate that it is used depending on the location of the inflammatory process. Before use, you must ensure that there is no sediment or foreign particles in the solution bottle and shake the container thoroughly.

• In ophthalmology, bacteriophage is used by instilling 1-2 drops of solution into the conjunctival sac.
• In otorhinolaryngology, 2-3 drops are instilled into the ear, the nasopharyngeal mucosa is irrigated, and the drug solution is used to gargle.
• In pulmonology, the drug can be used in the form of inhalation using a compressor inhaler, as well as oral administration of the drug (a more detailed description is given below).
• In gynecology, it is used by introducing a solution of the drug of about 100-200 ml into the vaginal cavity.
• In urology - by introducing the drug into the bladder through a catheter, washing the urethra; in the case of pyelonephritis, the drug is taken only orally.
• For diseases of the gastrointestinal tract, the solution is taken orally and in the form of enemas.
• In surgery, staphylococcal bacteriophage is used for washing wounds, infected cavities (after removing the purulent contents, an amount of solution is administered slightly less than the volume of the substance removed from the wound), draining surgical wounds with tampons soaked in a solution of staphylococcal bacteriophage.

Analogs for the drug “Staphylococcal Bacteriophage” will be described below.

You need to know that if any antiseptics were used to wash the infected area, then before using the bacteriophage, these areas must be washed with sterile physiological solution of sodium chloride 0.9%. For purulent lesions of the skin and its layers, injections of the desired area with a sterile solution, lotions and applications are used. This is how “Staphylococcal bacteriophage” is used for Staphylococcus aureus.

In case of generalized infection, the drug is used orally as part of complex therapy. . In order to prevent acute respiratory infections and acute respiratory viral infections, the mucous membranes of the nasal and oral cavity are irrigated several times a day and in contact with a large number of people.

For the most effective treatment, along with external use, “Staphylococcal Bacteriophage” is taken orally.

The exact dosage of the drug depends on the age of the patient, the location and method of administration of the drug, and the severity of the pathological process. Can be used for children from the very first hours of life. The duration of treatment also depends on the degree of advanced disease and varies from 1 week to 1 month. In case of relapses, the drug can be used repeatedly throughout the year.

It should be noted that this article is for informational purposes only. For correct and effective treatment, prescription and compliance with exact dosages and appropriate use of the drug, you should seek help from a doctor. This is confirmed by the instructions for the medication “Staphylococcal Bacteriophage”.

For children, this requirement must be met first.

Contraindications

A contraindication to the use of the described drug can only be individual intolerance to the components of the drug. There are no other contraindications.

No side effects were detected.

Overdose: To date, there has been no information about overdose.

Storage conditions and features: in a dark place at a temperature from +2 0 C to +8 0 C. It is necessary to know the rules for working with drugs containing living organisms, namely: keep your hands sterile, keep the bottle cap (open only with clean hands), put the lid on only on the outer part; use a syringe with a sterile needle to pierce the cap of the bottle in order to remove the required part of the drug; do not allow any particles to enter the bottle.

If the solution is clear and has no sediment, it can be used throughout its shelf life.

This is how staphylococcal bacteriophage is used for Staphylococcus aureus, among others.

Impact on the ability to drive vehicles

At the moment, there is no data on the harmful effects of bacteriophages on a person’s ability to drive vehicles, as well as automated mechanisms.

Drops from pharmacies over the counter.