Blood transfusion shock emergency care. Blood transfusion complications. Blood transfusion shock. Clinic, diagnostics, emergency care. Homologous blood syndrome

Complications of a blood transfusion nature, such as the most severe - blood transfusion shock, are rightfully considered more dangerous for the patient. Doctors call the most common cause of complications and reactions of a blood transfusion nature a disrupted blood transfusion process that is incompatible with the Rh factor or inappropriate with the ABO system (about 60% of all cases).

Causes, features and changes in organs

The main factors causing complications, in more cases, are violations of the provisions of the rules of blood transfusion, inconsistency with the methods by which blood type is determined, and incorrect sampling when checking for compatibility. During the process of blood transfusion, which turns out to be incompatible according to the group's indications, massive hemolysis occurs inside the vessels, which is caused by the destruction of the donor's red blood cells, which occurs under the influence of agglutinins in the patient.

The pathogenesis of the shock state is characterized by such damaging agents as the main components of hemolysis (amines of biogenic origin, free hemoglobin, thromboplastin). Large concentrations of the listed substances provoke the occurrence of pronounced vasospasm, which is replaced by paretic dilation. This difference is the main reason for the resulting oxygen starvation of tissues and impaired microcirculation.

At the same time, the permeability of the vessel walls increases, the viscosity of the blood increases, which significantly worsens its rheological qualities, and further reduces the level of microcirculation. Due to hypoxia for a long time, and the simultaneous concentration of acidic metabolites, dysfunctions of organs and systems, as well as their morphological changes, appear. The stage of shock begins, at which immediate, emergency help is required.

The difference that characterizes blood transfusion shock is disseminated intravascular coagulation syndrome, which is accompanied by significant changes in hemostasis and microcirculatory process. All hemodynamic parameters change sharply. The syndrome is considered the main factor in the pathogenetic picture of disorders in the lungs, endocrine glands and liver. The main provocation of its development - the highest point of the clinical picture - is the full penetration of thromboplastin into the bloodstream from destroyed red blood cells - erythrocytes.

The kidneys at this time undergo characteristic changes associated with the concentration in the renal tubules of hematin hydrochloride (a metabolite of free hemoglobin) and the remnants of destroyed red blood cells. In combination with simultaneous spasm of the renal vessels, these changes cause a decrease in renal blood flow and a decrease in glomerular filtration. This combined clinical picture of disorders reveals the main reason why acute renal failure develops.

During the clinical picture of complications encountered during blood transfusion, there are 3 main periods:

• the actual onset of shock;
• the occurrence of acute renal failure;
• the process of disappearance of clinical signs of shock - convalescence.

Shock of a blood transfusion nature occurs specifically during the transfusion process, and/or immediately after it. It can last for a few minutes or for several hours. In some cases, shock does not manifest itself in a clear clinical picture, and is sometimes accompanied by pronounced manifestations that can be fatal.

Symptom Clinic

Signs of the onset of shock are:

• general anxiety;
• sudden excitement for a short period;
• feeling of cold, chills;
• painful sensations in the abdomen, chest, lower back;
• heavy breathing and shortness of breath;
• the appearance of a bluish tint of the skin and mucous membranes, signs of cyanosis.

Doctors call the appearance of pain in the lumbar region a “marker” symptom, or a pathognostic (pathognomonic) manifestation that characterizes this pathological condition.

It is accompanied by a gradual (or sharp) increase in disturbances of circulatory origin, signs of a state of shock (the appearance of tachycardia, a decrease in blood pressure, a failure of the heart rhythm with manifestations of acute cardiovascular failure).

Such manifestations as:

• change in facial skin color - redness, pallor;
• vomit;
• the appearance of temperature;
• “marbling” of the skin;
• convulsions;
• involuntary defecation and urination.

Doctors consider persistent hemolysis of blood vessels to be one of the symptoms of the early manifestation of a state of shock, with indicators of the breakdown of red blood cells - signs of hemoglobinemia or hemoglobinuria, hyperbilirubinemia, jaundice (enlarged liver). The urine turns brown, tests show a high protein content and destruction of red blood cells. The development of disturbances in the hemocoagulation process also begins sharply, the clinical picture of which is manifested by profuse bleeding. The severity and level of hemorrhagic diathesis depend on the same factors of the hemolytic process.

Doctors should be sure to monitor the blood transfusion process during operations performed under anesthesia, as symptoms may be mild or not appear at all.

Course of the pathology

The extent of the condition largely depends on the volume of incompatible red blood cells transfused, the type of primary disease and the condition of the patient before the blood transfusion procedure.

The level of pressure determines to what degree experts classify transfusion shock:

• 1st degree shock occurs when systolic blood pressure exceeds 90 mm Hg. Art.
• Stage 2 is characterized by pressure in the range of 71 mm Hg. Art. up to 90 mm Hg Art.
• Stage 3 is diagnosed when systolic blood pressure is less than 70 mm Hg. Art.

In most cases, timely assistance and properly carried out medical procedures make it possible to stop the circulatory disorder, bring the patient out of shock, and eliminate its consequences.

Although characteristic is considered to be an increase in temperature some time after the transfusion, the appearance of yellowness of the sclera and skin, with a gradual increase, and increased headache. After a certain period of time, functional disorders in the kidney area may begin, and acute renal failure may develop. This pathology continues through alternating stages: anuria-polyuria-recovery period.

When hemodynamic factors are stable, the following occurs:

• a sharp decrease in daily diuresis;
• state of overhydration of the body;
• increased levels of creatinine, plasma potassium and urea.

Principles and methods of treatment procedures

At the first manifestation of symptoms of transfusion shock, the blood transfusion process is immediately stopped, the drip for transfusion is disconnected, and saline solution is started to be infused. In this case, it is strictly forbidden to remove the needle from the vein, since you may lose ready-made access to the vein.

The main focus of recovery from shock is to restore all functions of the body, maintain them, relieve the syndrome, and eliminate the consequences in order to prevent further development of disorders.

Types of treatment procedures

• Infusion therapeutic methods. To stabilize hemodynamics and restore microcirculation, blood replacement solutions are transfused - rheopolyglucin is considered the best option (polyglucin and gelatin preparations are also used).

In addition, a 4% solution of sodium bicarbonate (soda solution) or lactasol is started to be administered as early as possible in order to initiate an alkaline reaction in the urine, which is an obstacle to the formation of hematin hydrochloride. In the future, it is advisable to transfuse solutions of polyions, which promote the excretion of free hemoglobin and also prevent the degradation of fibrinogens. The volume of the infusion procedure is controlled by the value of central venous pressure.

Forecasts

The patient’s future condition, and often life, depends on how timely and competently the rehabilitation therapy is carried out and all the appropriate measures are taken. If all procedures are carried out correctly in the first period (4-6 hours), doctors’ forecasts are positive, as is the patient’s complete return to a full-fledged lifestyle. Moreover, timely assistance in 75% of cases prevents severe organ dysfunction.

Today, medical practice cannot be imagined without blood transfusions. There are many indications for this procedure, the main goal is to restore the lost blood volume to the patient, which is necessary for the normal functioning of the body. Despite the fact that it belongs to the category of vital manipulations, doctors try not to resort to it for as long as possible. The reason is that complications during transfusion of blood and its components are common, the consequences of which for the body can be very serious.

The main indication for blood transfusion is acute blood loss - a condition when the patient loses more than 30% of his blood volume in a few hours. This procedure is also used if there is unstoppable bleeding, a state of shock, anemia, hematological, purulent-septic diseases, or massive surgical interventions.

The blood infusion stabilizes the patient, and the recovery process after a blood transfusion is much faster.

Post-transfusion complications

Post-transfusion complications during transfusion of blood and its components are common; this procedure is very risky and requires careful preparation. Side effects arise due to non-compliance with the rules of blood transfusion, as well as individual intolerance.

All complications are divided into two groups. The first includes a pyrogenic reaction, citrate and potassium intoxication, anaphylaxis, bacterial shock, and allergies. The second includes pathologies caused by incompatibility between the donor and recipient groups, such as blood transfusion shock, respiratory distress syndrome, renal failure, and coagulopathy.

Allergic reaction

Allergic reactions are the most common after blood transfusion. They are characterized by the following symptoms:

• skin rash;
• attacks of suffocation;
• Quincke's edema;
• nausea;
• vomit.

Allergies are provoked by individual intolerance to one of the components or sensitization to plasma proteins infused earlier.

Pyrogenic reactions

A pyrogenic reaction may occur within half an hour after infusion of the drugs. The recipient develops general weakness, fever, chills, headache, and myalgia.

The cause of this complication is the ingress of pyrogenic substances along with transfused media; they appear due to improper preparation of systems for transfusion. The use of disposable kits significantly reduces these reactions.

Citrate and potassium intoxication

Citrate intoxication occurs due to exposure of the body to sodium citrate, which is a preservative for hematological drugs. Most often it manifests itself during jet injection. Symptoms of this pathology are a decrease in blood pressure, changes in the electrocardiogram, clonic convulsions, respiratory failure, even apnea.

Potassium intoxication occurs when a large volume of drugs is administered that have been stored for more than two weeks. During storage, potassium levels in transfusion media increase significantly. This condition is characterized by lethargy, possible nausea with vomiting, bradycardia with arrhythmia, up to cardiac arrest.

To prevent these complications, before massive blood transfusion, the patient needs to be administered a 10% calcium chloride solution. It is recommended to pour in ingredients that were prepared no more than ten days ago.

Blood transfusion shock

Hemotransfusion shock is an acute reaction to a blood transfusion that occurs due to incompatibility between the donor and recipient groups. Clinical symptoms of shock may occur immediately or within 10-20 minutes after the start of the infusion.

This condition is characterized by arterial hypotension, tachycardia, shortness of breath, agitation, redness of the skin, and lower back pain. Post-transfusion complications during blood transfusion also affect the organs of the cardiovascular system: acute expansion of the heart, myocardial infarction, cardiac arrest. Long-term consequences of such an infusion are renal failure, disseminated intravascular coagulation syndrome, jaundice, hepatomegaly, splenomegaly, and coagulopathy.

There are three degrees of shock as complications after blood transfusion:

• mild is characterized by low blood pressure up to 90 mm Hg. st;
• average: systolic pressure decreases to 80 mmHg. st;
• severe - blood pressure drops to 70 mm Hg. Art.

At the first signs of transfusion shock, the infusion should be stopped immediately and medical assistance should be provided.

Respiratory distress syndrome

The development of post-transfusion complications and their severity can be unpredictable, even threatening the patient’s life. One of the most dangerous is the development of respiratory distress syndrome. This condition is characterized by acute impairment of respiratory function.

The cause of the pathology may be the administration of incompatible drugs or non-compliance with the red blood cell infusion technique. As a result, the recipient's blood clotting is impaired; it begins to penetrate the walls of blood vessels, filling the cavities of the lungs and other parenchymal organs.

Symptomatically: the patient feels shortness of breath, the heart rate increases, pulmonary shock develops, and oxygen starvation develops. During the examination, the doctor cannot listen to the affected part of the organ; on an x-ray, the pathology looks like a dark spot.

Coagulopathy

Among all the complications that appear after blood transfusion, coagulopathy is not the least important. This condition is characterized by a coagulation disorder, resulting in massive blood loss syndrome with severe complications for the body.

The reason lies in the rapid increase in acute intravascular hemolysis, which occurs as a result of non-compliance with the rules for infusion of red blood cells or transfusion of different types of blood. With a volumetric infusion of red cells alone, the ratio of platelets responsible for coagulation is significantly reduced. As a result, the blood does not clot, and the walls of the blood vessels become thinner and more penetrating.

Kidney failure

One of the most severe complications after blood transfusion is acute renal failure syndrome, the clinical symptoms of which can be divided into three degrees: mild, moderate and severe.

The first signs indicating it are severe pain in the lumbar region, hyperthermia, and chills. Next, the patient begins

red urine is released, which indicates the presence of blood, then oliguria appears. Later, the state of “shock kidney” occurs; it is characterized by the complete absence of urine in the patient. In a biochemical study, such a patient will have a sharp increase in urea levels.

Anaphylactic shock

Anaphylactic shock is the most severe condition among allergic diseases. The cause of the appearance is the products included in the canned blood.

The first symptoms appear instantly, and immediately after the start of the infusion. Anaphylaxis is characterized by shortness of breath, suffocation, rapid pulse, drop in blood pressure, weakness, dizziness, myocardial infarction, and cardiac arrest. The condition never occurs with high blood pressure.

Along with pyrogenic and allergic reactions, shock is life-threatening for the patient. Failure to provide assistance in a timely manner can lead to death.

Transfusion of incompatible blood

The most dangerous consequences for the patient’s life are the consequences of transfused blood of different types. The first signs indicating the onset of a reaction are weakness, dizziness, increased temperature, decreased blood pressure, shortness of breath, rapid heartbeat, and lower back pain.

In the future, the patient may develop myocardial infarction, renal and respiratory failure, hemorrhagic syndrome with subsequent massive bleeding. All these conditions require immediate response from medical staff and assistance. Otherwise, the patient may die.

Treatment of post-transfusion complications

After the first signs of post-transfusion complications appear, it is necessary to stop blood transfusion. Medical care and treatment are individual for each pathology, it all depends on which organs and systems are involved. Blood transfusion, anaphylactic shock, acute respiratory and renal failure require hospitalization of the patient in the intensive care unit.

For various allergic reactions, antihistamines are used for treatment, in particular:

• Suprastin;
• Tavegil;
• Diphenhydramine.

Calcium chloride solution, glucose with insulin, sodium chloride - these drugs are the first aid for potassium and citrate intoxication.

As for cardiovascular drugs, Strofanthin, Korglykon, Norepinephrine, Furosemide are used. In case of renal failure, an emergency hemodialysis session is performed.

Impaired respiratory function requires provision of oxygen supply, administration of euphilin, and in severe cases, connection to a ventilator.

Prevention of complications during blood transfusion

Prevention of post-transfusion complications consists of strict compliance with all norms. The transfusion procedure must be carried out by a transfusiologist.

As for the general rules, this includes compliance with all standards for the preparation, storage, and transportation of drugs. It is imperative to conduct an analysis to detect severe viral infections transmitted by hematological routes.

The most difficult complications that threaten the patient’s life are those caused by incompatibility of the transfused blood. To avoid such situations, you need to adhere to the preparation plan for the procedure.

The first thing the doctor does is determine the patient’s group affiliation and order the required drug. Upon receipt, you must carefully inspect the packaging for damage and the label, which indicates the date of preparation, shelf life, and patient information. If the packaging does not raise suspicions, the next step should be to determine the group and rhesus of the donor; this is necessary to be on the safe side, since incorrect diagnosis is possible at the collection stage.

After this, an individual compatibility test is carried out. To do this, the patient's serum is mixed with the donor's blood. If all checks have passed positively, they begin the transfusion procedure itself, making sure to conduct a biological test with each individual bottle of blood.

In case of massive blood transfusions, it is impossible to resort to jet infusion methods; it is advisable to use drugs that are stored for no more than 10 days; it is necessary to alternate the administration of red blood cells with plasma. If the technique is violated, complications are possible. If all standards are followed, the blood transfusion will be successful and the patient’s condition will improve significantly.

Hemotransfusion shock manifests itself in the first minutes when blood of an incompatible group is introduced into the human body. This condition is characterized by increased heart rate, difficulty breathing, a drop in blood pressure, disruption of the cardiovascular system, loss of consciousness and involuntary passage of urine and feces.

Reasons for the development of post-transfusion shock

Hemotransfusion shock occurs when incompatible blood is transfused if the group, Rh factor or other isoserological characteristics were determined incorrectly. Shock can also be caused by transfusion of compatible blood in cases where:

• the patient’s condition has not been sufficiently studied;
• the blood used for transfusion is of poor quality;
• there is incompatibility between the proteins of the recipient and the donor.

Blood transfusion shock

In most cases, immediately after, the patient’s condition temporarily improves, but later a picture of serious damage to the kidneys and liver is noted, which sometimes ends in death. Acute kidney dysfunction is accompanied by a further decrease and complete cessation of urination. You can also observe the appearance of signs of intravascular hemolysis and acute kidney dysfunction.

Depending on the patient’s pressure level, three stages of post-transfusion shock are distinguished:

• 1st - pressure up to 90 mm Hg. Art.;
• 2nd - up to 70 mm Hg. Art.;
• 3rd - below 70 mm Hg. Art.

The severity of the state of transfusion shock and its consequences directly depend on the disease itself, on the condition of the patient, his age, anesthesia and the amount of blood transfused.

If a patient develops transfusion shock, he requires the following emergency care:

1. Administration of sympatholytic, cardiovascular and antihistamine drugs, corticosteroids and inhalation of oxygen.
2. Transfusion of polyglucin, blood of a suitable group in a dosage of 250-500 ml or plasma in the same amount. Introduction of a 5% bicarbonate solution or 11% solution in an amount of 200-250 ml.
3. Perirenal bilateral according to A. V. Vishnevsky (administration of a novocaine solution of 0.25-0.5% in an amount of 60-100 ml).

In most cases, such anti-shock measures lead to an improvement in the patient's condition.

But the main anti-shock measure is exchange blood transfusion as the most effective treatment to prevent kidney damage at an early stage of complications. Exchange transfusion is performed only after a thorough examination of the donor and recipient. For this procedure, only fresh blood is used in a dosage of 1500-2000 ml.

Blood transfusion shock in the acute stage requires immediate treatment. With the development of anuria with azotemia, an “artificial kidney” device is currently successfully used, with the help of which the patient’s blood is cleansed of toxic products.

Post-transfusion reactions:

Allergic;

Pyrogenic;

Antigenic (non-hemolytic);

Blood transfusion complications

All complications after blood transfusion can be divided into 3 groups.

1. Mechanical errors

Air embolism

Thromboembolism

Thrombophlebitis

Circulatory overload

2. Reactive complications

2.1Blood transfusion shock as a result of:

Incompatibility of components according to the AB0 system

Incompatibilities of components according to the Rh system

Incompatibility of components with respect to antigens of other serological systems

2.2. Post-transfusion shock due to transfusion of poor-quality medium

Bacterial contamination

Overheating, hypothermia, hemolysis

Expiration of shelf life

Violation of storage temperature conditions

2.3. Anaphylactic shock

2.4. Citrate shock (with the simultaneous transfusion of a large amount of canned blood).

2.5. Massive transfusion syndrome

2.6. Acute pulmonary failure syndrome

3. Transmission of infectious diseases

3.1. Syphilis infection

3.2. Malaria infection

3.3. Viral hepatitis infection

3.4. HIV infection

3.5. Infection with herpes viral infections

Blood transfusion reactions

In addition to complications after blood transfusion, a person may experience hemotransfusion reactions , which, unlike complications, do not pose a threat to life. These include:

A) pyrogenic reactions

B) allergic reactions.

Pyrogenic reactions arise due to the ingress of pyrogens along with blood components. Pyrogens are produced by many bacteria, as well as as a result of poor asepsis when collecting blood. The reaction is manifested by increased body temperature, chills, and headache.

Allergic reactions appear a few minutes after the start of transfusion, due to sensitization to plasma proteins and various immunoglobulins. Manifested by shortness of breath, suffocation, skin rashes, swelling of the face, and urticaria. Occur more often during plasma and albumin transfusions.

Antigenic (non-hemolytic reactions) as a result of sensitization of the recipient with antigens during repeated transfusion, during pregnancy.

Manifested by chills, vomiting, lower back pain, shortness of breath, urticaria, temperature 39-40, in severe cases there may be bronchospasm, acute respiratory failure, loss of consciousness.

Prevention: compliance with the rules of asepsis and antisepsis when collecting and storing blood.

Careful collection of transfusion history.

The use of blood components with less pronounced reactive properties.

Individual selection of blood transfusion media.

Treatment.

Stop the transfusion without leaving the vein, add antihistamines, glucocorticosteroids, adrenaline, anti-shock solutions, blood substitutes, cardiac glycosides, fight against hyperthermia.

Mechanical errors

1. Air embolism

An air embolism occurs when the system is not filled correctly, due to air entering the patient’s vein along with blood during transfusion.

1.as a result of improper filling of the system

2. as a result of untimely stop of transfusion during blood transfusion under pressure.

Clinic: difficulty breathing, shortness of breath, pain and a feeling of pressure behind the sternum, cyanosis of the face, tachycardia.

Treatment: massive air embolism with the development of clinical death requires immediate resuscitation measures - chest compressions, mouth-to-mouth artificial respiration, calling a resuscitation team.

Prevention consists in strict compliance with all technical rules of transfusion, installation of systems and equipment. It is necessary to carefully fill all tubes and parts of the equipment with the transfusion medium, ensuring that air bubbles are removed from the tubes. Monitoring of the patient during the transfusion should be constant until its completion.

2. Thromboembolism- embolism with blood clots in the pulmonary arteries.

Causes: separation of a blood clot from varicose veins of the lower extremities, separation of blood clots forming in the vein near the tip of the needle, entry of blood clots formed in the transfused blood.

Pulmonary embolism clinic: sudden pain in the chest, a sharp increase or occurrence of shortness of breath, coughing, sometimes hemoptysis, pallor of the skin, cyanosis, in some cases patients develop collapse - cold sweat, drop in blood pressure, rapid pulse.

Treatment activators of fibrinolysis - streptases (streptodecases, urokinases),

Continuous intravenous administration of heparin (25,000-40,000 units per day), immediate jet administration of at least 600 ml of fresh frozen plasma under the control of a coagulogram, euphyllin, cardiac glycosides and other therapeutic measures are indicated.

Prevention correct preparation, stabilization of blood, use of disposable systems for transfusion using filters. In case of needle thrombosis, repeated puncture of the vein with another needle is necessary; in no case should you try to restore the patency of the thrombosed needle in various ways.

3. Thrombophlebitis— the formation of blood clots in the inflamed vein.

Cause: violation of aseptic rules, multiple infusion punctures.

Clinic: pain along the vein, redness, swelling, upon palpation - painful compaction along the vein.

Treatment: dressings with heparin ointment, alcohol compresses.

4. Circulatory overload SHF manifests itself and develops more often in patients with myocardial damage.

Cause: the introduction of a large amount of fluid in a short period of time and, as a result, expansion and cardiac arrest.

Clinic: difficulty breathing, chest tightness, facial cyanosis, decreased blood pressure, tachycardia, arrhythmias, increased central venous pressure.

Help: stop infusion, intravenous cardiac glycosides, diuretics, vasopressor amines (mesaton).

Reactive complications:

Blood transfusion shock

Causes:

Develops as a result of blood transfusion:

1. incompatible according to the ABO system (during a biological test or during a blood transfusion);

Rh incompatibility – (spasm after blood transfusion or after 6-12 hours the course is less violent).

Clinically, transfusion shock manifests itself:

• Short-term excitement;
• Pain in the chest, abdomen, lower back;
• Tachycardia occurs;
• Blood pressure decreases;

• The skin is first hyperemic, then suddenly becomes pale. If a person is under anesthesia, then signs of developing shock are severe bleeding from the surgical wound, persistent low blood pressure, and in the presence of a urinary catheter, the appearance of cherry or black urine.
• After 1-2 days, urine the color of “meat slop” appears;
• The amount of urine “oliguria” decreases;

Urine production stops (anuria).

Algorithm of the nurse's action

Actions	Target
1. stop intravenous infusion of donor blood	- prevention of worsening transfusion shock
2. maintain contact with the vein	— for infusion antishock therapy (as prescribed by a doctor)
3. call a doctor	— assessing the recipient’s condition, giving prescriptions
4. measure A/D and count pulse	— monitoring the recipient’s condition
5. provide a flow of fresh air	— prevention of hypoxia
6. Perform bladder catheterization (as prescribed by a doctor)	- monitoring kidney function and collecting urine for clinical analysis (detection of red blood cell hemolysis)
7. fulfillment of doctor’s medication prescriptions solution of promedol 1% 1 ml mezaton 2 ml or ephedrine 5% 2 ml or norepinephrine 0.2% 1 ml, solution of prednisolone 30-60 mg or hydrokartisone 125 mg; diphenhydramine 1% 2 ml or pipolfen 2.5% 2 ml or tavegil 2.5%, calcium chloride 10% 10ml, aminophylline 2.4% 10ml diuretics: 20% mannitol (15-50 g) lasix 100 mg once, up to 1000 per day antishock solution (polyglucin, gelatinol, 4% sodium bicarbonate solution. According to indications, the patient is connected to hemodialysis.	for pain relief to increase blood pressure to relieve spasm from the renal arteries to reduce the deposition of hemolysis products in the distal tubules of the nephron to maintain blood volume and stabilize blood pressure Correction of acid-base balance Removal from the body of substances that led to the development of shock
8. repeated A/D measurement and pulse counting	— monitoring the effectiveness of measures to eliminate blood transfusion shock

Citrate shock


Occurs as a result of transfusion of large quantities of blood prepared with sodium citrate, which binds calcium, causing hypocalcemia.

Clinic: a metallic taste in the mouth, pain behind the sternum, interfering with inhalation, a drop in blood pressure, bradycardia and convulsions (twitching of the muscles of the lips, tongue, lower leg, in severe cases - respiratory failure up to stoppage and asystole.

For prevention development of citrate shock during transfusion of large doses of blood and plasma, after each transfusion 500 ml of blood must be injected into a vein with 10%-10 ml of calcium chloride or calcium gluconate. Introduce the medium at a rate of 40-60 drops/min.

Treatment: stop administration, 10 ml of calcium chloride or 10-20 ml of calcium gluconate must be injected into the vein and monitor the ECG.

Hypocalcemia may occur during rapid transfusion of long-term stored blood (more than 14 days);

Clinic: bradycardia.

Prevention: Slow, drip administration (50-70 ml/min.)

The use of washed red blood cells,

Massive transfusion syndrome

It occurs when up to 3 liters of whole blood from many donors are introduced into the recipient’s bloodstream in a short period of time.

Clinic: bradycardia, ventricular fibrillation, asystole, wound bleeding, acidosis, anemia, development of hepatic renal failure.

Help: The use of fresh frozen plasma, rheopolyglucin, heparin, cardiac glycosides, aminophylline, protease inhibitors, plasmapheresis.

Prevention: Avoid transfusion of whole blood in large quantities.

Transfusions only for strict indications

Use of blood components and products.

The use of the patient's autologous blood (prepared before a planned operation) or taken from the patient's body cavities.

Acute pulmonary failure syndrome


After 3-7 days of storage, microclots form in the blood and aggregation of formed elements occurs. The lungs are the first filter on the path of transfused blood. The capillaries of the lungs retain microclots, which leads to thromboembolism of the pulmonary capillaries, and subsequently to the development of acute pulmonary failure.

Clinic: shortness of breath, cyanosis, tachycardia, moist rales, increased breathing of auxiliary muscles.

Prevention: use for transfusion of disposable systems using filters, blood transfusion with a shelf life of less than 7-10 days.

Septic shock


Occurs when transfusion of poor quality blood occurs,

Clinic: characterized by a sharp increase in temperature to 39-41ºС, chills, drop in blood pressure, abdominal pain, cramps, vomiting

Symptoms of multiple organ failure: anuria, enlarged liver, yellowness of the skin, dullness of heart sounds.

Prevention: visual macroscopic assessment of transfused blood. Blood transfusion with a valid expiration date.

Treatment: cessation of transfusion, administration of large doses of antibiotics, detoxification therapy, antishock therapy, corticosteroids, cardiac glycosides, plasmapheresis.

Blood transfusion shock is a collective concept that unites a number of similar clinical conditions that arise in response to extremely strong effects on the body of various factors, with hypotension, a critical decrease in blood flow in tissues, the development of tissue hypoxia and hypothermia.

When transfusing blood, the possible development of this severe condition should be taken into account.

Etiology

This transfusion complication occurs due to violation of the rules for manipulating blood or its components, errors in determining the blood group and the compatibility of the recipient’s and donor’s blood components.

The main factors leading to the development of a shock state are: the ABO antigenic system and the Rh factor system. There are also a huge number of other antigenic systems, but they rarely give such a complication.

Pathogenesis

Shock is an allergic reaction of type II - cytotoxic. It develops immediately during the transfusion or after a certain time after the procedure.

The development of hemolysis inside the vessels during blood infusion is possible if red blood cells begin to be destroyed due to incompatibility with the antigenic profile of the recipient's plasma.

The basis for the development of a shock state is the breakdown of red blood cells. This process leads to the release of specific substances that provoke spasm of blood vessels, and then their pathological dilation. The permeability of the vessel wall increases, which leads to the release of plasma into the tissue and thickening of the blood.

The release of a large number of substances into the blood that promote the formation of blood clots leads to the development of disseminated intravascular coagulation syndrome. Its pathogenesis is characterized by an initial increase in blood clotting with the formation of many small blood clots.

After consumption, when the blood can no longer clot, massive bleeding occurs. There is a disruption of blood flow in small vessels, which leads to insufficient oxygen supply to the internal organs, and, consequently, to their damage.

All organs suffer, including the kidneys. The breakdown products of hemoglobin accumulate in their glomeruli, which leads to a drop in the rate of blood filling and the development of kidney failure.

Shock clinic

There are 3 stages that appear in case of incompatibility:

1. Actually a shock.
2. Pathology of the kidneys, which is expressed by acute failure.
3. Recovery period.

The state of shock can last from several minutes to a couple of hours. It is possible to trace a clear relationship between the appearance of symptoms of transfusion shock and the transfusion

The patient's condition is initially characterized by a feeling of anxiety, causeless agitation, pain in the chest, abdominal and lumbar pain, chills, difficulty breathing, and bluish skin.

Low back pain is one of the most characteristic features of the development of this complication. Subsequently, vascular disorders begin to appear.

Characteristic symptoms:

1. Tachycardia.
2. A sharp decrease in blood pressure.
3. The appearance of signs of acute heart failure.

A common manifestation is changes in the patient’s facial skin (redness followed by pallor), skin spotting, dyspeptic disorders, increased body temperature, and inability to control urination.

Symptoms of blood transfusion shock - which develops inside the vessels, and. Its manifestations:

• Free hemoglobin to the blood.
• Hemoglobin in urine.
• Hyperbilirubinemia.
• Jaundice.
• Hepatomegaly.
• The color of urine changes: a brownish tint appears (in urine analysis - proteinuria and altered red blood cells).

As a result of hemolysis and the development of disseminated intravascular coagulation syndrome, a disruption of the blood coagulation system occurs, which is expressed by increased bleeding and the occurrence of hemorrhagic diathesis.

When blood is infused during surgeries performed using general anesthesia, symptoms may be erased. Surgeons may notice abnormal bleeding from the wound and urine the color of meat slop.

Anesthesiologists focus on a sharp drop in pressure. The duration and severity of pathological processes depend on the number of incompatible red blood cells injected, the characteristics of the pathological process in the patient and his state of health before the transfusion.

Degrees

There are 3 degrees of shock, the definition of which is based on systolic pressure:

• I Art. — SBP above 90 mm Hg. Art.
• II Art. — SBP ranges from 71 to 90 mm Hg. Art.
• III Art. — SBP below 70 mmHg. Art.

The possible outcome of shock is directly proportional to the course and duration of the reduced pressure. Most often, anti-shock measures help reverse changes in blood vessels and prevent complications of this condition.

Associated symptoms

After a while, there may be an increase in temperature, yellow coloration of the eyeballs, and constant headaches. This indicates the development of acute renal failure (ARF). It manifests itself in the form of three subsequent phases: oligo- or anuria, polyuria and the recovery phase.

Against the background of unchanged hemodynamic conditions, a sharp decrease in the amount of urine excreted is observed, initial signs of hydration of the body are observed, and the level of creatinine, urea and potassium in the plasma increases (oliguria phase).

After some time, diuresis is restored. Despite this, high levels of trace elements in the blood may persist (polyuria phase). In the future, with a favorable outcome, the filtration capacity of the kidneys is restored.

This pathological condition ends with the restoration of all pathological processes in the body (the period of convalescence).

Transfusion shock is a condition that requires emergency care. The algorithm of actions in this situation can be presented as follows:

• Removing the patient from a state of shock.
• Measures to prevent pathological changes in important organs and correct them.
• Relief of developing DIC syndrome.
• Prevention of development of acute renal failure.

If adverse symptoms appear, the first action of the nurse or doctor is to stop the transfusion procedure and replace the system with saline solutions.

The most important factor is time: the faster medical interventions are performed, the better the prognosis for the patient.

Infusion therapy

All shock treatment regimens begin with infusions.

First of all, it is necessary to replenish the circulating blood volume (CBV) and restore hemostatic function (dextrans with a molecular weight of 40-70 thousand units are used - rheopolyglucin, gelatinol).

Early infusion of a 4% solution of sodium bicarbonate or lactosol is also indicated. In this way, compensation for metabolic acidification of the blood is ensured, and the synthesis of hematin hydrochloride does not occur.

Subsequently, a crystalloid infusion is performed (with a solution of 0.9% sodium chloride or Ringer's solution) to reduce the amount of free Hb and prevent the destruction of fibrinogen. The amount of infused drugs must be controlled by the volume of diuresis and pressure values.

Drug therapy

It is necessary to raise the patient's blood pressure, as well as ensure normal renal blood flow. A triad of standard antishock drugs: prednisolone (a glucocorticosteroid to increase blood pressure), furosemide (a diuretic) and aminophylline (a phosphodiesterase inhibitor). Antihistamines and opioid painkillers (fentanyl) are also used.

Efferent methods

An effective method of anti-shock therapy is plasmapheresis - removal of about 2 liters of plasma followed by infusion of fresh frozen plasma and colloid solutions. Symptomatic correction of disorders of the internal organs.

If necessary, medications are prescribed that stimulate the activity of important body systems. If symptoms characteristic of a decrease in the respiratory function of the lungs appear, the patient may be transferred to a ventilator. In case of severe anemia (hemoglobin concentration less than 70 g/l), it is possible to transfuse washed red blood cells compatible in blood group with the patient's red blood cells.

Correction of the hemostatic system

Anticoagulants are used, transfusions of fresh frozen plasma and antienzyme drugs (Gordox) are performed to inhibit fibrinolysis.

Since the development of acute renal failure is possible in the future, treatment of transfusion shock is also aimed at correcting the functional state of the kidneys. Furosemide and mannitol are used and correction is performed with crystalloid solutions.

If there is no effect, hemodialysis may be used. During the recovery period, specific symptoms are treated.

Prevention

To avoid the development of shock during transfusion, you need to follow some rules (this is a kind of prevention):

• Before a blood infusion, you need to collect a detailed history, in which it is important to focus on previous transfusions or infusions.
• Comply with all rules for conducting compatibility tests (if there are errors or inaccuracies, repeat the procedure).

Indications for blood transfusion

In addition to the development of a state of shock, other complications associated with the infusion of blood components are also possible. These may be pyrogenic or allergic reactions, thrombosis or acute aneurysm. Therefore, it is important to treat it carefully and use it only for certain indications.

Absolute readings:

1. Massive blood loss (more than 15% of blood volume).
2. Shock states.
3. Severe traumatic operations with heavy bleeding.

Relative readings:

1. Anemia.
2. Severe intoxication.
3. Disturbance of the hemostasis system.

Contraindications

There are also a number of prohibitions. Absolute contraindications:

• Acute heart failure.
• Myocardial infarction.

Relative contraindications:

• Heart defects.
• The presence of blood clots or emboli in the vascular bloodstream.
• Cerebral circulation disorders.
• Tuberculosis.
• Kidney or liver failure.

It is important to know that if there are absolute indications, then blood or its components are transfused in any case. Even if there are contraindications.

Conclusion

Transfusion shock is a serious and not the only complication that occurs during transfusions, therefore, even in an emergency, all necessary tests should be carefully carried out and the rules of blood transfusions should be followed.

If signs of transfusion shock are observed, it is important to begin treatment as quickly as possible, which will improve the prognosis for the patient.